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• W2807562649 abstract "Abstract Cardiovascular disease (CVD) is the leading global cause of death. Diet is known to be important in the prevention of CVD. The PREDIMED trial tested a relatively low-fat diet versus a high-fat Mediterranean diet (MedDiet) for the primary prevention of CVD. The resulting reduction of the CV composite outcome resulted in a paradigm shift in CV nutrition. Though many dietary factors likely contributed to this effect, this review focuses on the influence of the MedDiet on endogenous antioxidant systems and the effect of dietary polyphenols. Subgroup analysis of the PREDIMED trial revealed increased endogenous antioxidant and decreased pro-oxidant activity in the MedDiet groups. Moreover, higher polyphenol intake was associated with lower incidence of the primary outcome, overall mortality, blood pressure, inflammatory biomarkers, onset of new-onset type 2 diabetes mellitus (T2DM), and obesity. This suggests that polyphenols likely contributed to the lower incidence of the primary event in the MedDiet groups. In this article, we summarize the potential benefits of polyphenols found in the MedDiet, specifically the PREDIMED cohort. We also discuss the need for further research to confirm and expand the findings of the PREDIMED in a non-Mediterranean population and to determine the exact mechanisms of action of polyphenols." @default.
• W2807562649 created "2018-06-13" @default.
• W2807562649 creator A5052105348 @default.
• W2807562649 creator A5077688590 @default.
• W2807562649 date "2018-03-09" @default.
• W2807562649 modified "2023-10-14" @default.
• W2807562649 title "The antioxidant potential of the Mediterranean diet in patients at high cardiovascular risk: an in-depth review of the PREDIMED" @default.
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• W2807562649 doi "https://doi.org/10.1038/s41387-018-0025-1" @default.
• W2807562649 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5856841" @default.
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• W2807562649 hasPublicationYear "2018" @default.
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