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• W2807584689 abstract "Abstract The aim of this study was to investigate whether a surface coating with graphene could enhance the surface bioactivation of titanium alloys (Ti 6 Al 4 V) to further accelerate in vivo osteogenesis and osseointegration at the implant surface. In this study, a New Zealand white rabbit femoral condyle defect model was established. After 4, 12 and 24 weeks, biomechanical testing, micro-computed tomography (Micro-CT) analyses and histological observations were performed. At the highest push-out forces during the test, microstructure parameters, such as the bone volume/total volume fraction (BV/TV) and mineral apposition rate (MAR), of the new bone were significantly higher in the graphene-coated Ti 6 Al 4 V group (G-Ti 6 Al 4 V) than in the Ti 6 Al 4 V group ( P < 0.05). Van Gieson (VG) staining showed that the G-Ti 6 Al 4 V group had more new bone formation than the Ti 6 Al 4 V group, and the G-Ti 6 Al 4 V group showed a closer fit between the bone and implant. In conclusion, graphene might be a novel type of nano-coating material for enhancing the surface biological activity of Ti-based alloy materials and may further promote in vivo osteogenesis and osseointegration." @default.
• W2807584689 created "2018-06-13" @default.
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• W2807584689 date "2018-01-30" @default.
• W2807584689 modified "2023-10-10" @default.
• W2807584689 title "Evaluation of the osteogenesis and osseointegration of titanium alloys coated with graphene: an in vivo study" @default.
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• W2807584689 doi "https://doi.org/10.1038/s41598-018-19742-y" @default.
• W2807584689 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5790016" @default.
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