FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807593721> ?p ?o ?g. }

• W2807593721 endingPage "064007" @default.
• W2807593721 startingPage "064007" @default.
• W2807593721 abstract "Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease characterized by excessive deposition of collagen and associated stiffening of lung tissue. While it is known that inflammation and dysfunction of fibroblasts are involved in disease development, it remains poorly understood how cells and their microenvironment interact to produce a characteristic subpleural pattern of high and low tissue density variations, called honeycombing, on CT images of patients with IPF. Since the pleura is stiffer than the parenchyma, we hypothesized that local stiffness of the underlying extracellular matrix can influence fibroblast activation and consequently the deposition of collagen, which in turn influences tissue stiffness in a positive feedback loop.We tested this hypothesis by developing a hybrid physics-based/agent-based computational model in which aberrant fibroblast activation is induced when cells migrate on stiff tissue. This activation then feeds back on itself via the altered mechanical environment that it creates by depositing collagen.The model produces power law distributions of both low- and high-attenuation area clusters and predicts the development of honeycombing only when mechanical rupture is allowed to take place in highly strained normal tissue surrounded by stiff fibrotic tissue. These predictions compare well with histologic data computed from CT images of patients with IPF.We conclude that the clinical manifestation of subpleural honeycombing in IPF may result from fibroblasts entering into a positive feedback loop induced by the abnormally high tissue stiffness near the pleura." @default.
• W2807593721 created "2018-06-13" @default.
• W2807593721 creator A5009336302 @default.
• W2807593721 creator A5010785236 @default.
• W2807593721 creator A5014570718 @default.
• W2807593721 creator A5039542656 @default.
• W2807593721 creator A5045629242 @default.
• W2807593721 date "2018-06-28" @default.
• W2807593721 modified "2023-10-15" @default.
• W2807593721 title "Topographic distribution of idiopathic pulmonary fibrosis: a hybrid physics- and agent-based model" @default.
• W2807593721 cites W1966871331 @default.
• W2807593721 cites W1982268629 @default.
• W2807593721 cites W1983639828 @default.
• W2807593721 cites W1986019547 @default.
• W2807593721 cites W1993559550 @default.
• W2807593721 cites W1996505814 @default.
• W2807593721 cites W2006574930 @default.
• W2807593721 cites W2018006093 @default.
• W2807593721 cites W2024250498 @default.
• W2807593721 cites W2027170202 @default.
• W2807593721 cites W2031938767 @default.
• W2807593721 cites W2048035811 @default.
• W2807593721 cites W2050511745 @default.
• W2807593721 cites W2059646444 @default.
• W2807593721 cites W2066794375 @default.
• W2807593721 cites W2076721693 @default.
• W2807593721 cites W2113542991 @default.
• W2807593721 cites W2116043657 @default.
• W2807593721 cites W2125023876 @default.
• W2807593721 cites W2136007367 @default.
• W2807593721 cites W2139507936 @default.
• W2807593721 cites W2147209470 @default.
• W2807593721 cites W2151047625 @default.
• W2807593721 cites W2151551276 @default.
• W2807593721 cites W2159731793 @default.
• W2807593721 cites W2169583190 @default.
• W2807593721 cites W2260133387 @default.
• W2807593721 cites W2276748319 @default.
• W2807593721 cites W2417519204 @default.
• W2807593721 cites W2463345971 @default.
• W2807593721 cites W2469102333 @default.
• W2807593721 cites W2530294125 @default.
• W2807593721 cites W2533186452 @default.
• W2807593721 cites W2585483507 @default.
• W2807593721 cites W2605134373 @default.
• W2807593721 cites W2606597561 @default.
• W2807593721 cites W2615675311 @default.
• W2807593721 cites W2616087011 @default.
• W2807593721 cites W2626588662 @default.
• W2807593721 cites W2740897511 @default.
• W2807593721 cites W2757116276 @default.
• W2807593721 cites W2788966615 @default.
• W2807593721 cites W2970426266 @default.
• W2807593721 cites W3104607524 @default.
• W2807593721 doi "https://doi.org/10.1088/1361-6579/aaca86" @default.
• W2807593721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6057779" @default.
• W2807593721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29870400" @default.
• W2807593721 hasPublicationYear "2018" @default.
• W2807593721 type Work @default.
• W2807593721 sameAs 2807593721 @default.
• W2807593721 citedByCount "21" @default.
• W2807593721 countsByYear W28075937212018 @default.
• W2807593721 countsByYear W28075937212019 @default.
• W2807593721 countsByYear W28075937212020 @default.
• W2807593721 countsByYear W28075937212021 @default.
• W2807593721 countsByYear W28075937212022 @default.
• W2807593721 countsByYear W28075937212023 @default.
• W2807593721 crossrefType "journal-article" @default.
• W2807593721 hasAuthorship W2807593721A5009336302 @default.
• W2807593721 hasAuthorship W2807593721A5010785236 @default.
• W2807593721 hasAuthorship W2807593721A5014570718 @default.
• W2807593721 hasAuthorship W2807593721A5039542656 @default.
• W2807593721 hasAuthorship W2807593721A5045629242 @default.
• W2807593721 hasBestOaLocation W28075937212 @default.
• W2807593721 hasConcept C126322002 @default.
• W2807593721 hasConcept C142724271 @default.
• W2807593721 hasConcept C159985019 @default.
• W2807593721 hasConcept C185592680 @default.
• W2807593721 hasConcept C189165786 @default.
• W2807593721 hasConcept C192562407 @default.
• W2807593721 hasConcept C196822366 @default.
• W2807593721 hasConcept C207865475 @default.
• W2807593721 hasConcept C2777714996 @default.
• W2807593721 hasConcept C2778341716 @default.
• W2807593721 hasConcept C2779372316 @default.
• W2807593721 hasConcept C2779412668 @default.
• W2807593721 hasConcept C2780381497 @default.
• W2807593721 hasConcept C2780559512 @default.
• W2807593721 hasConcept C2781244666 @default.
• W2807593721 hasConcept C54355233 @default.
• W2807593721 hasConcept C71924100 @default.
• W2807593721 hasConcept C81885089 @default.
• W2807593721 hasConcept C86803240 @default.
• W2807593721 hasConcept C95444343 @default.
• W2807593721 hasConceptScore W2807593721C126322002 @default.
• W2807593721 hasConceptScore W2807593721C142724271 @default.
• W2807593721 hasConceptScore W2807593721C159985019 @default.
• W2807593721 hasConceptScore W2807593721C185592680 @default.

• next