FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807637103> ?p ?o ?g. }

• W2807637103 endingPage "2280" @default.
• W2807637103 startingPage "2267" @default.
• W2807637103 abstract "Purpose Therapies with novel mechanisms of action are needed for multiple myeloma (MM). T cells can be genetically modified to express chimeric antigen receptors (CARs), which are artificial proteins that target T cells to antigens. B-cell maturation antigen (BCMA) is expressed by normal and malignant plasma cells but not normal essential cells. We conducted the first-in-humans clinical trial, to our knowledge, of T cells expressing a CAR targeting BCMA (CAR-BCMA). Patients and Methods Sixteen patients received 9 × 10 6 CAR-BCMA T cells/kg at the highest dose level of the trial; we are reporting results of these 16 patients. The patients had a median of 9.5 prior lines of MM therapy. Sixty-three percent of patients had MM refractory to the last treatment regimen before protocol enrollment. T cells were transduced with a γ-retroviral vector encoding CAR-BCMA. Patients received CAR-BCMA T cells after a conditioning chemotherapy regimen of cyclophosphamide and fludarabine. Results The overall response rate was 81%, with 63% very good partial response or complete response. Median event-free survival was 31 weeks. Responses included eradication of extensive bone marrow myeloma and resolution of soft-tissue plasmacytomas. All 11 patients who obtained an anti-MM response of partial response or better and had MM evaluable for minimal residual disease obtained bone marrow minimal residual disease–negative status. High peak blood CAR + cell levels were associated with anti-MM responses. Cytokine-release syndrome toxicities were severe in some cases but were reversible. Blood CAR-BCMA T cells were predominantly highly differentiated CD8 + T cells 6 to 9 days after infusion. BCMA antigen loss from MM was observed. Conclusion CAR-BCMA T cells had substantial activity against heavily treated relapsed/refractory MM. Our results should encourage additional development of CAR T-cell therapies for MM." @default.
• W2807637103 created "2018-06-13" @default.
• W2807637103 creator A5003258570 @default.
• W2807637103 creator A5008205966 @default.
• W2807637103 creator A5014636271 @default.
• W2807637103 creator A5017546608 @default.
• W2807637103 creator A5032315182 @default.
• W2807637103 creator A5035585356 @default.
• W2807637103 creator A5036697217 @default.
• W2807637103 creator A5037782727 @default.
• W2807637103 creator A5057158251 @default.
• W2807637103 creator A5062706815 @default.
• W2807637103 creator A5065696086 @default.
• W2807637103 creator A5065897197 @default.
• W2807637103 creator A5066218992 @default.
• W2807637103 creator A5072166479 @default.
• W2807637103 creator A5072199664 @default.
• W2807637103 creator A5072304255 @default.
• W2807637103 creator A5074654320 @default.
• W2807637103 creator A5076686446 @default.
• W2807637103 creator A5079704265 @default.
• W2807637103 creator A5089904138 @default.
• W2807637103 creator A5090875956 @default.
• W2807637103 date "2018-08-01" @default.
• W2807637103 modified "2023-10-11" @default.
• W2807637103 title "T Cells Genetically Modified to Express an Anti–B-Cell Maturation Antigen Chimeric Antigen Receptor Cause Remissions of Poor-Prognosis Relapsed Multiple Myeloma" @default.
• W2807637103 cites W1647507681 @default.
• W2807637103 cites W1721778868 @default.
• W2807637103 cites W1935116877 @default.
• W2807637103 cites W1966542058 @default.
• W2807637103 cites W1971371234 @default.
• W2807637103 cites W1981480494 @default.
• W2807637103 cites W2004300203 @default.
• W2807637103 cites W2013296669 @default.
• W2807637103 cites W2044436186 @default.
• W2807637103 cites W2045475405 @default.
• W2807637103 cites W2047203592 @default.
• W2807637103 cites W2049790267 @default.
• W2807637103 cites W2068367301 @default.
• W2807637103 cites W2072546530 @default.
• W2807637103 cites W2094945699 @default.
• W2807637103 cites W2099570622 @default.
• W2807637103 cites W2102694800 @default.
• W2807637103 cites W2104195581 @default.
• W2807637103 cites W2118796952 @default.
• W2807637103 cites W2123525329 @default.
• W2807637103 cites W2124373740 @default.
• W2807637103 cites W2124513722 @default.
• W2807637103 cites W2129702476 @default.
• W2807637103 cites W2130338247 @default.
• W2807637103 cites W2136100686 @default.
• W2807637103 cites W2140579395 @default.
• W2807637103 cites W2145345130 @default.
• W2807637103 cites W2153147430 @default.
• W2807637103 cites W2158966732 @default.
• W2807637103 cites W2170513194 @default.
• W2807637103 cites W2216303864 @default.
• W2807637103 cites W2265134611 @default.
• W2807637103 cites W2340862784 @default.
• W2807637103 cites W2342423058 @default.
• W2807637103 cites W2413807845 @default.
• W2807637103 cites W2471662063 @default.
• W2807637103 cites W2509364267 @default.
• W2807637103 cites W2602369513 @default.
• W2807637103 cites W2734515449 @default.
• W2807637103 cites W2739972212 @default.
• W2807637103 cites W2751416367 @default.
• W2807637103 cites W2755114342 @default.
• W2807637103 cites W2757334017 @default.
• W2807637103 cites W2774686348 @default.
• W2807637103 cites W2775001520 @default.
• W2807637103 cites W4252175385 @default.
• W2807637103 doi "https://doi.org/10.1200/jco.2018.77.8084" @default.
• W2807637103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6067798" @default.
• W2807637103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29812997" @default.
• W2807637103 hasPublicationYear "2018" @default.
• W2807637103 type Work @default.
• W2807637103 sameAs 2807637103 @default.
• W2807637103 citedByCount "520" @default.
• W2807637103 countsByYear W28076371032017 @default.
• W2807637103 countsByYear W28076371032018 @default.
• W2807637103 countsByYear W28076371032019 @default.
• W2807637103 countsByYear W28076371032020 @default.
• W2807637103 countsByYear W28076371032021 @default.
• W2807637103 countsByYear W28076371032022 @default.
• W2807637103 countsByYear W28076371032023 @default.
• W2807637103 crossrefType "journal-article" @default.
• W2807637103 hasAuthorship W2807637103A5003258570 @default.
• W2807637103 hasAuthorship W2807637103A5008205966 @default.
• W2807637103 hasAuthorship W2807637103A5014636271 @default.
• W2807637103 hasAuthorship W2807637103A5017546608 @default.
• W2807637103 hasAuthorship W2807637103A5032315182 @default.
• W2807637103 hasAuthorship W2807637103A5035585356 @default.
• W2807637103 hasAuthorship W2807637103A5036697217 @default.
• W2807637103 hasAuthorship W2807637103A5037782727 @default.
• W2807637103 hasAuthorship W2807637103A5057158251 @default.
• W2807637103 hasAuthorship W2807637103A5062706815 @default.
• W2807637103 hasAuthorship W2807637103A5065696086 @default.

• next