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• W2807643095 abstract "Significance Microbes often live in dense populations such as colonies and biofilms. We show that the success and extinction of yeast strains within a growing colony are determined by a combination of their relative fitness and the forces exerted by proliferating cells on their neighbors. These physical interactions prolong the survival of less-fit strains at the growing frontier of the colony and slow down the colony’s takeover by fitter strains. This reduction in the power of natural selection favors the maintenance of genetic diversity in environments in which the strains’ relative growth rates vary with time. Growth-induced physical interactions may thus favor the maintenance of drug-resistant cells, which are typically less fit than nonresistant cells, within dense microbial populations." @default.
• W2807643095 created "2018-06-13" @default.
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• W2807643095 date "2018-10-23" @default.
• W2807643095 modified "2023-10-05" @default.
• W2807643095 title "Physical interactions reduce the power of natural selection in growing yeast colonies" @default.
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• W2807643095 doi "https://doi.org/10.1073/pnas.1809587115" @default.
• W2807643095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6233111" @default.
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