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- W2807660003 abstract "Asymmetric division is crucial for embryonic development and stem cell lineages. In the one-cell C. elegans embryo, a contractile cortical actomyosin network contributes to asymmetric division by segregating PAR proteins to discrete cortical domains. Here, we discovered that the plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2) localizes to polarized dynamic structures in C. elegans zygotes, distributing in a PAR-dependent manner along the anterior-posterior (A-P) embryonic axis. PIP2 cortical structures overlap with F-actin, and coincide with the actin regulators RHO-1, CDC-42 as well as ECT-2. Particle image velocimetry analysis revealed that PIP2 and F-actin cortical movements are coupled, with PIP2 structures moving slightly ahead. Importantly, we established that PIP2 cortical structure formation and movement is actin-dependent. Conversely, we found that decreasing or increasing the level of PIP2 results in severe F-actin disorganization, revealing interdependence between these components. Furthermore, we uncovered that PIP2 and F-actin regulate the sizing of PAR cortical domains, including during the maintenance phase of polarization. Overall, our work establishes that a lipid membrane component, PIP2, modulates actin organization and cell polarity in C. elegans embryos." @default.
- W2807660003 created "2018-06-13" @default.
- W2807660003 creator A5016890522 @default.
- W2807660003 creator A5022997911 @default.
- W2807660003 creator A5042673216 @default.
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- W2807660003 creator A5054432666 @default.
- W2807660003 creator A5055703082 @default.
- W2807660003 creator A5082270721 @default.
- W2807660003 date "2018-01-01" @default.
- W2807660003 modified "2023-10-03" @default.
- W2807660003 title "PI(4,5)P2 forms dynamic cortical structures and directs actin distribution as well as polarity in <i>C. elegans</i> embryos" @default.
- W2807660003 cites W100587655 @default.
- W2807660003 cites W1496078104 @default.
- W2807660003 cites W1496990179 @default.
- W2807660003 cites W1880487999 @default.
- W2807660003 cites W1944127002 @default.
- W2807660003 cites W1963969404 @default.
- W2807660003 cites W1967284833 @default.
- W2807660003 cites W1968726375 @default.
- W2807660003 cites W1974059924 @default.
- W2807660003 cites W1976995232 @default.
- W2807660003 cites W1979762239 @default.
- W2807660003 cites W1989971869 @default.
- W2807660003 cites W1992171856 @default.
- W2807660003 cites W1997784032 @default.
- W2807660003 cites W2003416037 @default.
- W2807660003 cites W2012229898 @default.
- W2807660003 cites W2015852214 @default.
- W2807660003 cites W2019365008 @default.
- W2807660003 cites W2019830418 @default.
- W2807660003 cites W2020955446 @default.
- W2807660003 cites W2021124770 @default.
- W2807660003 cites W2026796085 @default.
- W2807660003 cites W2031333220 @default.
- W2807660003 cites W2034146282 @default.
- W2807660003 cites W2034542874 @default.
- W2807660003 cites W2036324161 @default.
- W2807660003 cites W2037102374 @default.
- W2807660003 cites W2037437989 @default.
- W2807660003 cites W2038492783 @default.
- W2807660003 cites W2040150379 @default.
- W2807660003 cites W2044254863 @default.
- W2807660003 cites W2045598409 @default.
- W2807660003 cites W2048961736 @default.
- W2807660003 cites W2050876666 @default.
- W2807660003 cites W2060297895 @default.
- W2807660003 cites W2064823036 @default.
- W2807660003 cites W2069090018 @default.
- W2807660003 cites W2070113801 @default.
- W2807660003 cites W2070487296 @default.
- W2807660003 cites W2073557891 @default.
- W2807660003 cites W2074790072 @default.
- W2807660003 cites W2077608775 @default.
- W2807660003 cites W2080786759 @default.
- W2807660003 cites W2082688327 @default.
- W2807660003 cites W2083868899 @default.
- W2807660003 cites W2085035388 @default.
- W2807660003 cites W2089080652 @default.
- W2807660003 cites W2091401847 @default.
- W2807660003 cites W2091884933 @default.
- W2807660003 cites W2093510463 @default.
- W2807660003 cites W2094231976 @default.
- W2807660003 cites W2096358322 @default.
- W2807660003 cites W2101417222 @default.
- W2807660003 cites W2107257359 @default.
- W2807660003 cites W2107662757 @default.
- W2807660003 cites W2112782187 @default.
- W2807660003 cites W2117132491 @default.
- W2807660003 cites W2119352312 @default.
- W2807660003 cites W2123298030 @default.
- W2807660003 cites W2124814491 @default.
- W2807660003 cites W2125022739 @default.
- W2807660003 cites W2125394700 @default.
- W2807660003 cites W2132846761 @default.
- W2807660003 cites W2134283668 @default.
- W2807660003 cites W2135424590 @default.
- W2807660003 cites W2137072938 @default.
- W2807660003 cites W2137382396 @default.
- W2807660003 cites W2138221697 @default.
- W2807660003 cites W2138360579 @default.
- W2807660003 cites W2143614744 @default.
- W2807660003 cites W2144420636 @default.
- W2807660003 cites W2144751111 @default.
- W2807660003 cites W2153841101 @default.
- W2807660003 cites W2155705022 @default.
- W2807660003 cites W2161930851 @default.
- W2807660003 cites W2161988248 @default.
- W2807660003 cites W2166254523 @default.
- W2807660003 cites W2167567258 @default.
- W2807660003 cites W2170319238 @default.
- W2807660003 cites W2170976706 @default.
- W2807660003 cites W2173958468 @default.
- W2807660003 cites W2332601173 @default.
- W2807660003 cites W2417702944 @default.
- W2807660003 cites W2471526055 @default.
- W2807660003 cites W2596080911 @default.
- W2807660003 cites W2737413500 @default.
- W2807660003 cites W2742344312 @default.
- W2807660003 cites W4210338521 @default.