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• W2807682004 abstract "Tyrosine kinase receptors (TKRs) play critical roles in gastric cancer (GC) progression, and have a potential to be targets for novel molecular targeted agents. In the process of patient selection for molecular target agents, targeted biopsy under endoscopic observation is the first step. However, heterogeneous expression of TKRs through the macroscopic appearance in GC has not been extensively addressed. To investigate the difference of heterogeneity in TKRs such as HER2, EGFR, c-MET through the macroscopic appearance of GC. Between August 2011 and March 2015, 414 consecutive patients had undergone gastrectomy at the National Cancer Center Hospital East. The inclusion criteria were as follows: (1)histologically proven adenocarcinoma, (2)available archived tumor sample, and (3)no prior history of chemotherapy. Representative tumor areas were selected and tumor cores were assembled in a tissue microarray (TMA) format. TMA samples were examined for TKRs using immunohistochemistry (IHC). We defined TKR positivity as an IHC score of 2+ or 3+. Based on the result of IHC in TMA, detailed examination cases were selected. The following condition cases were selected preferentially. (1)IHC score: 3+ (than 2+), (2)multiple IHC score: 2+ or 3+, (3)mucosal lesion remaining. Several cases with all negative were selected as control. For these selection cases, TKR expression was investigated in more than 3 tumor blocks per case. We reevaluated IHC score, and comparatively evaluated the difference of IHC expression in each molecule between macroscopic appearance of mucosal portion (MP) and invasive portion (IP). A total of 375 patients fulfilled study criteria. HER2, EGFR, and c-MET-positive rate was 6% (22), 9% (32), and 20% (76), respectively. To assess the difference of IHC expression portion, we selected 26 cases (HER2, EGFR, c-MET-positive, all negative: 12, 11, 12, 4). After reevaluation, HER2, EGFR, c-MET-positive, and all negative was 17, 5, 9, 5 cases, respectively. For the assessment of the difference of expression portion, the IHC expression was divided into three patterns designated as MP=IP, MP>IP, and MP<IP. In HER2-positive GCs, the rate of MP=IP, MP>IP, and MP<IP was 53%, 47%, and 0%, respectively. In EGFR, MP=IP, MP>IP, and MP<IP was 40%, 0%, and 60%, respectively. In c-MET, MP=IP, MP>IP, and MP<IP was 11%, 44%, and 44%, respectively. We calculated concordance rate of IHC expression of MP and IP compared to the whole tumor. In HER2-positive GCs, the concordance rate of MP and IP compared to the whole tumor was 100% and 53%, respectively. In EGFR, MP and IP was 40% and 100%, respectively. In c-MET, MP and IP was 55% and 55%, respectively. To avoid underestimating of expression status, biopsies must be taken from MP in HER2, IP in EGFR, and both proportion in c-MET under precise observation." @default.
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• W2807682004 date "2018-06-01" @default.
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• W2807682004 title "Sa1225 HER2, EGFR, AND C-MET-POSITIVE SITE OF GASTRIC CANCER USING THE SURGICAL SAMPLES" @default.
• W2807682004 doi "https://doi.org/10.1016/j.gie.2018.04.1426" @default.
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