Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807705689> ?p ?o ?g. }
- W2807705689 endingPage "e129" @default.
- W2807705689 startingPage "e117" @default.
- W2807705689 abstract "Our previous studies have shown that mesencephalic astrocyte-derived neurotrophic factor (MANF) provides a neuroprotective effect against ischemia/reperfusion injury and is also involved in inflammatory disease models. This study investigates the potential role and mechanism of MANF in acute brain damage after traumatic brain injury (TBI). The model of TBI was induced by Feeney free falling methods with male Sprague-Dawley rats. The expression of MANF, 24 hours after TBI, was detected by the immunohistochemistry, immunofluorescence, Western blot, and reverse transcription polymerase chain reaction techniques. After treatment with recombinant human MANF after TBI, assessment was conducted 24 hours later for brain water content, cerebral edema volume in magnetic resonance imaging, neurobehavioral testing, and Evans blue extravasation. Moreover, by the techniques of Western blot and reverse transcription polymerase chain reaction, the expression of inflammatory cytokines (interleukin 1β and tumor necrosis factor α) and P65 was also analyzed to explore the underlying protective mechanism of MANF. At 24 hours after TBI, we found that endogenous MANF was widely expressed in the rat's brain tissues and different types of cells. Treatment with a high dose of recombinant human MANF (20 μg/20 μL) significantly increased the modified Garcia score, and reduced brain water content as well as cerebral edema volume on magnetic resonance imaging. Furthermore, MANF alleviated not only the permeability of the blood-brain barrier (BBB) but also the expressions of interleukin 1β and tumor necrosis factor α messenger RNA and protein. Besides, the activation of P65 was also inhibited. These results suggest that MANF provides a neuroprotective effect against acute brain injury after TBI, via attenuating blood-brain barrier disruption and intracranial neuroinflammation; the inhibition of the NF-κB signaling pathway might be a potential mechanism." @default.
- W2807705689 created "2018-06-13" @default.
- W2807705689 creator A5010441210 @default.
- W2807705689 creator A5030866090 @default.
- W2807705689 creator A5045522507 @default.
- W2807705689 creator A5047303618 @default.
- W2807705689 creator A5055424731 @default.
- W2807705689 creator A5057947122 @default.
- W2807705689 creator A5065972440 @default.
- W2807705689 date "2018-09-01" @default.
- W2807705689 modified "2023-09-28" @default.
- W2807705689 title "Mesencephalic Astrocyte-Derived Neurotrophic Factor Prevents Traumatic Brain Injury in Rats by Inhibiting Inflammatory Activation and Protecting the Blood-Brain Barrier" @default.
- W2807705689 cites W118450234 @default.
- W2807705689 cites W1503803513 @default.
- W2807705689 cites W1973559709 @default.
- W2807705689 cites W1976422798 @default.
- W2807705689 cites W1982536484 @default.
- W2807705689 cites W1983265620 @default.
- W2807705689 cites W1985277235 @default.
- W2807705689 cites W1988094797 @default.
- W2807705689 cites W1990014090 @default.
- W2807705689 cites W1996614758 @default.
- W2807705689 cites W2001626206 @default.
- W2807705689 cites W2004389897 @default.
- W2807705689 cites W2007533257 @default.
- W2807705689 cites W2010045296 @default.
- W2807705689 cites W2013900800 @default.
- W2807705689 cites W2016535081 @default.
- W2807705689 cites W2023505129 @default.
- W2807705689 cites W2023774170 @default.
- W2807705689 cites W2027686066 @default.
- W2807705689 cites W2031213243 @default.
- W2807705689 cites W2042146447 @default.
- W2807705689 cites W2054805566 @default.
- W2807705689 cites W2062868334 @default.
- W2807705689 cites W2064711537 @default.
- W2807705689 cites W2065064718 @default.
- W2807705689 cites W2066860622 @default.
- W2807705689 cites W2073814752 @default.
- W2807705689 cites W2080881511 @default.
- W2807705689 cites W2084674974 @default.
- W2807705689 cites W2094715296 @default.
- W2807705689 cites W2095916445 @default.
- W2807705689 cites W2104048011 @default.
- W2807705689 cites W2106958893 @default.
- W2807705689 cites W2107639627 @default.
- W2807705689 cites W2112462557 @default.
- W2807705689 cites W2126967674 @default.
- W2807705689 cites W2127906377 @default.
- W2807705689 cites W2130136843 @default.
- W2807705689 cites W2136765648 @default.
- W2807705689 cites W2138274734 @default.
- W2807705689 cites W2140729052 @default.
- W2807705689 cites W2158496649 @default.
- W2807705689 cites W2163357760 @default.
- W2807705689 cites W2169076855 @default.
- W2807705689 cites W2169531008 @default.
- W2807705689 cites W2202315187 @default.
- W2807705689 cites W2342347873 @default.
- W2807705689 cites W2511409581 @default.
- W2807705689 cites W2517393594 @default.
- W2807705689 cites W2548765116 @default.
- W2807705689 doi "https://doi.org/10.1016/j.wneu.2018.05.202" @default.
- W2807705689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29883817" @default.
- W2807705689 hasPublicationYear "2018" @default.
- W2807705689 type Work @default.
- W2807705689 sameAs 2807705689 @default.
- W2807705689 citedByCount "18" @default.
- W2807705689 countsByYear W28077056892019 @default.
- W2807705689 countsByYear W28077056892020 @default.
- W2807705689 countsByYear W28077056892021 @default.
- W2807705689 countsByYear W28077056892022 @default.
- W2807705689 countsByYear W28077056892023 @default.
- W2807705689 crossrefType "journal-article" @default.
- W2807705689 hasAuthorship W2807705689A5010441210 @default.
- W2807705689 hasAuthorship W2807705689A5030866090 @default.
- W2807705689 hasAuthorship W2807705689A5045522507 @default.
- W2807705689 hasAuthorship W2807705689A5047303618 @default.
- W2807705689 hasAuthorship W2807705689A5055424731 @default.
- W2807705689 hasAuthorship W2807705689A5057947122 @default.
- W2807705689 hasAuthorship W2807705689A5065972440 @default.
- W2807705689 hasConcept C104317684 @default.
- W2807705689 hasConcept C118552586 @default.
- W2807705689 hasConcept C126322002 @default.
- W2807705689 hasConcept C134018914 @default.
- W2807705689 hasConcept C142724271 @default.
- W2807705689 hasConcept C160539049 @default.
- W2807705689 hasConcept C164027704 @default.
- W2807705689 hasConcept C170493617 @default.
- W2807705689 hasConcept C17991360 @default.
- W2807705689 hasConcept C185592680 @default.
- W2807705689 hasConcept C203014093 @default.
- W2807705689 hasConcept C25498285 @default.
- W2807705689 hasConcept C2776415932 @default.
- W2807705689 hasConcept C2776914184 @default.
- W2807705689 hasConcept C2777542381 @default.
- W2807705689 hasConcept C2777649898 @default.
- W2807705689 hasConcept C2778402981 @default.