FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807715871> ?p ?o ?g. }

• W2807715871 abstract "The only current curative treatment for patients with pancreatic ductal adenocarcinoma (PDA) is surgical resection, and certain patients still succumb to disease shortly after complete surgical resection. Wilms' tumor 1 (WT1) serves an oncogenic role in various types of tumors; therefore, in the present study, WT1 protein expression in patients with PDA was analyzed and the association with overall survival (OS) and disease-free survival (DFS) time in patients with PDA was assessed following surgical resection. A total of 50 consecutive patients with PDA who received surgical resection between January 2005 and December 2015 at the Jikei University Kashiwa Hospital (Kashiwa, Chiba, Japan) were enrolled. WT1 protein expression in PDA tissue was measured using immunohistochemical staining. Furthermore, laboratory parameters were measured within 2 weeks of surgery, and systemic inflammatory response markers were evaluated. WT1 protein expression was detected in the nucleus and cytoplasm of all PDA cells and in tumor vessels. WT1 exhibited weak staining in the nuclei of all PDA cells; however, the cytoplasmic expression of WT1 levels was classified into four groups: Negative (n=0), weak (n=19), moderate (n=23) and strong (n=8). In patients with PDA, it was demonstrated that the OS and DFS times of patients with weak cytoplasmic WT1 expression were significantly prolonged compared with those of patients with moderate-to-strong cytoplasmic WT1 expression, as determined by log-rank test (P=0.0005 and P=0.0001, respectively). Furthermore, an association between the density of WT1-expressing tumor vessels and worse OS/DFS times was detected. Multivariate analysis also indicated a significant association between the overexpression of WT1 in PDA tissue and worse OS/DFS times. To the best of our knowledge, the present study is the first to demonstrate that moderate-to-strong overexpression of WT1 in the cytoplasm of PDA cells is significantly associated with worse OS/DFS times. Therefore, overexpression of WT1 in the cytoplasm of PDA cells may impact the recurrence and prognosis of patients with PDA following surgical resection. The results further support the development of WT1-targeted therapies to prolong survival in all patients with PDA." @default.
• W2807715871 created "2018-06-21" @default.
• W2807715871 creator A5003016176 @default.
• W2807715871 creator A5004685668 @default.
• W2807715871 creator A5021069937 @default.
• W2807715871 creator A5021836764 @default.
• W2807715871 creator A5024838892 @default.
• W2807715871 creator A5031736405 @default.
• W2807715871 creator A5032750544 @default.
• W2807715871 creator A5038214190 @default.
• W2807715871 creator A5039762495 @default.
• W2807715871 creator A5054899877 @default.
• W2807715871 creator A5057400638 @default.
• W2807715871 creator A5062795615 @default.
• W2807715871 creator A5068934114 @default.
• W2807715871 creator A5070590061 @default.
• W2807715871 creator A5073572164 @default.
• W2807715871 creator A5079360360 @default.
• W2807715871 date "2018-06-13" @default.
• W2807715871 modified "2023-09-23" @default.
• W2807715871 title "Prognostic significance of Wilms' tumor 1 expression in patients with pancreatic ductal adenocarcinoma" @default.
• W2807715871 cites W1769953224 @default.
• W2807715871 cites W1892171691 @default.
• W2807715871 cites W1910112145 @default.
• W2807715871 cites W1965533994 @default.
• W2807715871 cites W1967124261 @default.
• W2807715871 cites W1970383271 @default.
• W2807715871 cites W1971646898 @default.
• W2807715871 cites W1976615153 @default.
• W2807715871 cites W1978139448 @default.
• W2807715871 cites W1979415195 @default.
• W2807715871 cites W1980097192 @default.
• W2807715871 cites W1980449293 @default.
• W2807715871 cites W1986081674 @default.
• W2807715871 cites W1991947126 @default.
• W2807715871 cites W1994693679 @default.
• W2807715871 cites W2003442577 @default.
• W2807715871 cites W2008474545 @default.
• W2807715871 cites W2009088519 @default.
• W2807715871 cites W2014702305 @default.
• W2807715871 cites W2018141896 @default.
• W2807715871 cites W2022067890 @default.
• W2807715871 cites W2028210790 @default.
• W2807715871 cites W2030676407 @default.
• W2807715871 cites W2032229065 @default.
• W2807715871 cites W2042356959 @default.
• W2807715871 cites W2046064533 @default.
• W2807715871 cites W2046070143 @default.
• W2807715871 cites W2056514645 @default.
• W2807715871 cites W2057909978 @default.
• W2807715871 cites W2062024852 @default.
• W2807715871 cites W2065857975 @default.
• W2807715871 cites W2072652974 @default.
• W2807715871 cites W2080148780 @default.
• W2807715871 cites W2081734471 @default.
• W2807715871 cites W2082068518 @default.
• W2807715871 cites W2085086086 @default.
• W2807715871 cites W2087371737 @default.
• W2807715871 cites W2089931232 @default.
• W2807715871 cites W2090954031 @default.
• W2807715871 cites W2113027268 @default.
• W2807715871 cites W2115073791 @default.
• W2807715871 cites W2117025284 @default.
• W2807715871 cites W2117357598 @default.
• W2807715871 cites W2123105952 @default.
• W2807715871 cites W2127712120 @default.
• W2807715871 cites W2129355295 @default.
• W2807715871 cites W2134121541 @default.
• W2807715871 cites W2138767374 @default.
• W2807715871 cites W2148069086 @default.
• W2807715871 cites W2148971136 @default.
• W2807715871 cites W2160391606 @default.
• W2807715871 cites W2161817637 @default.
• W2807715871 cites W2202192283 @default.
• W2807715871 cites W2292094308 @default.
• W2807715871 cites W2473247105 @default.
• W2807715871 cites W2565199841 @default.
• W2807715871 cites W2573152477 @default.
• W2807715871 cites W2591639510 @default.
• W2807715871 cites W2780490957 @default.
• W2807715871 cites W2785056616 @default.
• W2807715871 cites W4229719081 @default.
• W2807715871 doi "https://doi.org/10.3892/ol.2018.8961" @default.
• W2807715871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6036545" @default.
• W2807715871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30008944" @default.
• W2807715871 hasPublicationYear "2018" @default.
• W2807715871 type Work @default.
• W2807715871 sameAs 2807715871 @default.
• W2807715871 citedByCount "7" @default.
• W2807715871 countsByYear W28077158712018 @default.
• W2807715871 countsByYear W28077158712019 @default.
• W2807715871 countsByYear W28077158712020 @default.
• W2807715871 countsByYear W28077158712021 @default.
• W2807715871 crossrefType "journal-article" @default.
• W2807715871 hasAuthorship W2807715871A5003016176 @default.
• W2807715871 hasAuthorship W2807715871A5004685668 @default.
• W2807715871 hasAuthorship W2807715871A5021069937 @default.
• W2807715871 hasAuthorship W2807715871A5021836764 @default.
• W2807715871 hasAuthorship W2807715871A5024838892 @default.
• W2807715871 hasAuthorship W2807715871A5031736405 @default.

• next