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- W2807718717 abstract "Background Analysis of antinuclear antibodies (ANA) may be found in malignant diseases Objectives To study the prevalence of ANA in breast cancer patients and its association with tumour characteristics. Methods Ninety one patients with breast mass detected by image studies and assigned to do diagnostic biopsy and eventual surgical treatment were studied for demographical, tumour data and presence of ANA. Serum of positive ANA patients was submitted to examination of ENA (extractable nuclear antigens) profile. As comparison 91 healthy individuals paired for age and from same geographical area had ANA determination. Results In this sample 72/91 (79.1%) had malignant lesions (83% ductal infiltrative carcinoma). Ana was positive in 44.4% of malignant tumour patients, in 15.7% of benign lesions (p=0.03) and in 5.4% of controls (p (*) OR=4.8 (95%CI=1.33–17.7) Figure 1 Prevalence of ANA in patients with breast tumours and controls Conclusions In this sample there was a high prevalence of ANA positivity in breast cancer patients with a negative association with the presence of hormone receptors. References [1] Pisetsky DS. Antinuclear antibody testing - misunderstood or misbegotten?Nat Rev Rheumatol2017;13:495–502. [2] Madrid FF, Maroun MC, Olivero OA, Long M, Stark A, Grossman L, et al. Autoantibodies in breast cancer sera are not epiphenomena and may participate in carcinogenesis. BMC Cancer2015;15:407. [3] Chapman C, Murray A, Chakrabarti J, Thorpe A, Woolston C, Sahin U, et al. Autoantibodies in breast cancer: their use as an aid to early diagnosis. Ann Oncol2007;18:868–73. [4] Akram M, Iqbal M, Daniyal M, Khan AU. Awareness and current knowledge of breast cancer. Biol Res2017;50:33. [5] Ortona E, Pierdominici M, Berstein L. Autoantibodies to estrogen receptors and their involvement in autoimmune diseases and cancer. J Steroid Biochem Mol Biol2014;144 Pt B:260–7. [6] Mohammed ME, Abdelhafiz K. Autoantibodies in the sera of breast cancer patients: Antinuclear and anti-double stranded DNA antibodies as example. J Cancer Res Ther2015;11:341–4. [7] Bernatsky S, Ramsey-Goldman R, Petri M, Urowitz MB, Gladman DD, Fortin PF, et al. Breast cancer in systemic lupus. Lupus2017; 26:311–5. Disclosure of Interest None declared" @default.
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- W2807718717 date "2018-06-01" @default.
- W2807718717 modified "2023-09-26" @default.
- W2807718717 title "THU0707 Analysis of antinuclear antibodies in breast cancer patients" @default.
- W2807718717 doi "https://doi.org/10.1136/annrheumdis-2018-eular.4950" @default.
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