Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807720210> ?p ?o ?g. }
- W2807720210 abstract "INTRODUCTION: Tremor of the upper limbs is a disabling symptom that is present during several neurological disorders and is currently without treatment. Functional MRI (fMRI) is an essential tool to investigate the pathophysiology of tremor and aid the development of treatment options. However, no adequately or standardised protocols for fMRI exists at present. Here we present a novel, online available fMRI task that could be used to assess the in vivo pathology of tremor. OBJECTIVE: This study aims to validate the tremor-evoking potential of the fMRI task in a small group of tremor patients outside the scanner and assess the reproducibility of the fMRI task related activation in healthy controls. METHODS: Twelve HCs were scanned at two time points (baseline and after 6-weeks). There were two runs of multi-band fMRI and the tasks included a ‘brick-breaker’ joystick game. The game consisted of three conditions designed to control for most of the activation related to performing the task by contrasting the conditions: WATCH (look at the game without moving joystick), MOVE (rhythmic left/right movement of joystick without game), and PLAY (playing the game). Task fMRI was analysed using FSL FEAT to determine clusters of activation during the different conditions. Maximum activation within the clusters was used to assess the ability to control for task related activation and reproducibility. Four tremor patients have been included to test ecological and construct validity of the joystick task by assessing tremor frequencies captured by the joystick. RESULTS: In HCs the game activated areas corresponding to motor, attention and visual areas. Most areas of activation by our game showed moderate to good reproducibility (intraclass correlation coefficient (ICC) 0.531 to 0.906) with only inferior parietal lobe activation showing poor reproducibility (ICC 0.446). Furthermore, the joystick captured significantly more tremulous movement in tremor patients compared to HCs (p=0.01) during PLAY, but not during MOVE. CONCLUSION: Validation of our novel task confirmed tremor-evoking potential and reproducibility analyses yielded acceptable results to continue further investigations into the pathophysiology of tremor. The use of this technique in studies with tremor patient will no doubt provide significant insights into the treatment options." @default.
- W2807720210 created "2018-06-21" @default.
- W2807720210 creator A5014845568 @default.
- W2807720210 creator A5028230236 @default.
- W2807720210 creator A5029697366 @default.
- W2807720210 creator A5034515419 @default.
- W2807720210 creator A5038879117 @default.
- W2807720210 creator A5042431509 @default.
- W2807720210 creator A5051597403 @default.
- W2807720210 creator A5061656425 @default.
- W2807720210 creator A5062591344 @default.
- W2807720210 creator A5070930882 @default.
- W2807720210 date "2018-07-02" @default.
- W2807720210 modified "2023-09-25" @default.
- W2807720210 title "Novel Functional MRI Task for Studying the Neural Correlates of Upper Limb Tremor" @default.
- W2807720210 cites W1766416546 @default.
- W2807720210 cites W1933941917 @default.
- W2807720210 cites W1955549025 @default.
- W2807720210 cites W1964131902 @default.
- W2807720210 cites W1966304693 @default.
- W2807720210 cites W1967031555 @default.
- W2807720210 cites W1971255930 @default.
- W2807720210 cites W1976904670 @default.
- W2807720210 cites W1977679116 @default.
- W2807720210 cites W1981198880 @default.
- W2807720210 cites W1998408021 @default.
- W2807720210 cites W2001551864 @default.
- W2807720210 cites W2004181233 @default.
- W2807720210 cites W2010626531 @default.
- W2807720210 cites W2017440739 @default.
- W2807720210 cites W2023057525 @default.
- W2807720210 cites W2028158865 @default.
- W2807720210 cites W2028305596 @default.
- W2807720210 cites W2029087300 @default.
- W2807720210 cites W2046688982 @default.
- W2807720210 cites W2054014402 @default.
- W2807720210 cites W2067456724 @default.
- W2807720210 cites W2073630554 @default.
- W2807720210 cites W2079329115 @default.
- W2807720210 cites W2084769181 @default.
- W2807720210 cites W2091193959 @default.
- W2807720210 cites W2100816330 @default.
- W2807720210 cites W2101762436 @default.
- W2807720210 cites W2112165124 @default.
- W2807720210 cites W2128344635 @default.
- W2807720210 cites W2128820615 @default.
- W2807720210 cites W2133072808 @default.
- W2807720210 cites W2133410948 @default.
- W2807720210 cites W2150702829 @default.
- W2807720210 cites W2156598044 @default.
- W2807720210 cites W2161520815 @default.
- W2807720210 cites W2256830025 @default.
- W2807720210 cites W2327037637 @default.
- W2807720210 cites W2618938660 @default.
- W2807720210 cites W2765248650 @default.
- W2807720210 cites W33147833 @default.
- W2807720210 cites W4233994114 @default.
- W2807720210 doi "https://doi.org/10.3389/fneur.2018.00513" @default.
- W2807720210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6036145" @default.
- W2807720210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30013508" @default.
- W2807720210 hasPublicationYear "2018" @default.
- W2807720210 type Work @default.
- W2807720210 sameAs 2807720210 @default.
- W2807720210 citedByCount "6" @default.
- W2807720210 countsByYear W28077202102019 @default.
- W2807720210 countsByYear W28077202102020 @default.
- W2807720210 countsByYear W28077202102021 @default.
- W2807720210 countsByYear W28077202102022 @default.
- W2807720210 crossrefType "journal-article" @default.
- W2807720210 hasAuthorship W2807720210A5014845568 @default.
- W2807720210 hasAuthorship W2807720210A5028230236 @default.
- W2807720210 hasAuthorship W2807720210A5029697366 @default.
- W2807720210 hasAuthorship W2807720210A5034515419 @default.
- W2807720210 hasAuthorship W2807720210A5038879117 @default.
- W2807720210 hasAuthorship W2807720210A5042431509 @default.
- W2807720210 hasAuthorship W2807720210A5051597403 @default.
- W2807720210 hasAuthorship W2807720210A5061656425 @default.
- W2807720210 hasAuthorship W2807720210A5062591344 @default.
- W2807720210 hasAuthorship W2807720210A5070930882 @default.
- W2807720210 hasBestOaLocation W28077202101 @default.
- W2807720210 hasConcept C15744967 @default.
- W2807720210 hasConcept C162324750 @default.
- W2807720210 hasConcept C169760540 @default.
- W2807720210 hasConcept C187736073 @default.
- W2807720210 hasConcept C2779226451 @default.
- W2807720210 hasConcept C2780112193 @default.
- W2807720210 hasConcept C2780451532 @default.
- W2807720210 hasConcept C3018412434 @default.
- W2807720210 hasConcept C41008148 @default.
- W2807720210 hasConcept C44154836 @default.
- W2807720210 hasConcept C49774154 @default.
- W2807720210 hasConcept C71924100 @default.
- W2807720210 hasConcept C96439379 @default.
- W2807720210 hasConcept C99508421 @default.
- W2807720210 hasConceptScore W2807720210C15744967 @default.
- W2807720210 hasConceptScore W2807720210C162324750 @default.
- W2807720210 hasConceptScore W2807720210C169760540 @default.
- W2807720210 hasConceptScore W2807720210C187736073 @default.
- W2807720210 hasConceptScore W2807720210C2779226451 @default.
- W2807720210 hasConceptScore W2807720210C2780112193 @default.