Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807737762> ?p ?o ?g. }
- W2807737762 endingPage "1786" @default.
- W2807737762 startingPage "1786" @default.
- W2807737762 abstract "Obesity and dyslipidemia are major risk factors for the development of cardiovascular diseases (CVD). Quercetin, a natural flavonoid, lowers plasma triglycerides (TG) in human intervention studies, and its intake is associated with lower CVD risk. The aim of this study was to elucidate the mechanism by which quercetin lowers plasma TG levels in diet-induced obesity. C57Bl/6J mice received a high-fat diet (45% of calories derived from fat) with or without quercetin (0.1% w/w) for 12 weeks. Quercetin decreased plasma TG levels from nine weeks onwards (−19%, p < 0.05), without affecting food intake, body composition, or energy expenditure. Mechanistically, quercetin did not reduce intestinal fatty acid (FA) absorption. Rather, quercetin induced a slight reduction in liver Apob expression (−13%, p < 0.05), which suggests decreased very-low density lipoprotein-TG production. Interestingly, quercetin also markedly increased the uptake of [3H]oleate, which was derived from glycerol tri[3H]oleate-labeled lipoprotein-like particles by subcutaneous white adipose tissue (sWAT, +60%, p < 0.05). Furthermore, quercetin also markedly increased mRNA expression of Ucp1 (+229%, p < 0.05) and Elovl3 (+138%, p < 0.05), specifically in sWAT. Accordingly, only quercetin-treated animals showed uncoupling protein-1 protein-positive cells in sWAT, which is fully compatible with increased browning. Taken together, the TG-lowering effect of quercetin may, at least in part, be due to increased TG-derived FA uptake by sWAT as a consequence of browning." @default.
- W2807737762 created "2018-06-21" @default.
- W2807737762 creator A5016480998 @default.
- W2807737762 creator A5024072938 @default.
- W2807737762 creator A5025954248 @default.
- W2807737762 creator A5035385427 @default.
- W2807737762 creator A5049287339 @default.
- W2807737762 creator A5060123483 @default.
- W2807737762 date "2018-06-16" @default.
- W2807737762 modified "2023-10-06" @default.
- W2807737762 title "Quercetin Lowers Plasma Triglycerides Accompanied by White Adipose Tissue Browning in Diet-Induced Obese Mice" @default.
- W2807737762 cites W1533556857 @default.
- W2807737762 cites W1876464893 @default.
- W2807737762 cites W1914622032 @default.
- W2807737762 cites W1972570240 @default.
- W2807737762 cites W1976398031 @default.
- W2807737762 cites W1987030874 @default.
- W2807737762 cites W1996154370 @default.
- W2807737762 cites W2001868230 @default.
- W2807737762 cites W2016601006 @default.
- W2807737762 cites W2017549783 @default.
- W2807737762 cites W2032149290 @default.
- W2807737762 cites W2032612125 @default.
- W2807737762 cites W2033374657 @default.
- W2807737762 cites W2039956167 @default.
- W2807737762 cites W2041811148 @default.
- W2807737762 cites W2043062741 @default.
- W2807737762 cites W2049970571 @default.
- W2807737762 cites W2092083734 @default.
- W2807737762 cites W2095549936 @default.
- W2807737762 cites W2095693480 @default.
- W2807737762 cites W2115311024 @default.
- W2807737762 cites W2124135959 @default.
- W2807737762 cites W2132358997 @default.
- W2807737762 cites W2133194624 @default.
- W2807737762 cites W2136309995 @default.
- W2807737762 cites W2140503505 @default.
- W2807737762 cites W2144943167 @default.
- W2807737762 cites W2147472208 @default.
- W2807737762 cites W2155413431 @default.
- W2807737762 cites W2167019376 @default.
- W2807737762 cites W2169582126 @default.
- W2807737762 cites W2182463894 @default.
- W2807737762 cites W2286999219 @default.
- W2807737762 cites W2318465668 @default.
- W2807737762 cites W2530492717 @default.
- W2807737762 cites W2556751659 @default.
- W2807737762 cites W2560630257 @default.
- W2807737762 cites W2571586100 @default.
- W2807737762 cites W2576351065 @default.
- W2807737762 cites W2740170876 @default.
- W2807737762 cites W2762948888 @default.
- W2807737762 doi "https://doi.org/10.3390/ijms19061786" @default.
- W2807737762 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6032193" @default.
- W2807737762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29914151" @default.
- W2807737762 hasPublicationYear "2018" @default.
- W2807737762 type Work @default.
- W2807737762 sameAs 2807737762 @default.
- W2807737762 citedByCount "44" @default.
- W2807737762 countsByYear W28077377622019 @default.
- W2807737762 countsByYear W28077377622020 @default.
- W2807737762 countsByYear W28077377622021 @default.
- W2807737762 countsByYear W28077377622022 @default.
- W2807737762 countsByYear W28077377622023 @default.
- W2807737762 crossrefType "journal-article" @default.
- W2807737762 hasAuthorship W2807737762A5016480998 @default.
- W2807737762 hasAuthorship W2807737762A5024072938 @default.
- W2807737762 hasAuthorship W2807737762A5025954248 @default.
- W2807737762 hasAuthorship W2807737762A5035385427 @default.
- W2807737762 hasAuthorship W2807737762A5049287339 @default.
- W2807737762 hasAuthorship W2807737762A5060123483 @default.
- W2807737762 hasBestOaLocation W28077377621 @default.
- W2807737762 hasConcept C126322002 @default.
- W2807737762 hasConcept C134018914 @default.
- W2807737762 hasConcept C151955695 @default.
- W2807737762 hasConcept C171089720 @default.
- W2807737762 hasConcept C185592680 @default.
- W2807737762 hasConcept C2778004101 @default.
- W2807737762 hasConcept C2778096610 @default.
- W2807737762 hasConcept C2778163477 @default.
- W2807737762 hasConcept C2779054382 @default.
- W2807737762 hasConcept C2780072125 @default.
- W2807737762 hasConcept C2780780548 @default.
- W2807737762 hasConcept C2781263971 @default.
- W2807737762 hasConcept C511355011 @default.
- W2807737762 hasConcept C544821477 @default.
- W2807737762 hasConcept C55493867 @default.
- W2807737762 hasConcept C62746215 @default.
- W2807737762 hasConcept C71924100 @default.
- W2807737762 hasConcept C86803240 @default.
- W2807737762 hasConceptScore W2807737762C126322002 @default.
- W2807737762 hasConceptScore W2807737762C134018914 @default.
- W2807737762 hasConceptScore W2807737762C151955695 @default.
- W2807737762 hasConceptScore W2807737762C171089720 @default.
- W2807737762 hasConceptScore W2807737762C185592680 @default.
- W2807737762 hasConceptScore W2807737762C2778004101 @default.
- W2807737762 hasConceptScore W2807737762C2778096610 @default.
- W2807737762 hasConceptScore W2807737762C2778163477 @default.