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- W2807776105 abstract "目的:研究雷公藤内酯醇(Triptolide,TPL)对非小细胞肺癌细胞A549细胞增殖抑制作用和促凋亡影响的分子机制.方法:以A549细胞为研究对象,采用MTT法测定细胞增殖;吖啶橙/溴乙啶(AO/EB)荧光染色法检测细胞凋亡;Caspase3活性检测试剂盒分析其凋亡机制.结果:在6.25～100 ng·ml-1,12～72 h范围内,TPL对A549细胞增殖具有明显抑制作用(P＜0.01),48 h内其凋亡率随着时间延长而增加,Caspase3活性早期较对照组有显著提高(P＜0.05),并于12 h达到最高值.结论:TPL能有效抑制A549细胞的增殖,这种抑制作用可能与TPL促进肿瘤细胞凋亡,激活Caspase3活性有关." @default.
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- W2807776105 date "2007-01-01" @default.
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- W2807776105 title "Apoptosis of Cancer Cells Inducing by Triptolide on Human Non-small Cell Lung Cancer in Vitro" @default.
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