FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807778587> ?p ?o ?g. }

• W2807778587 endingPage "3078" @default.
• W2807778587 startingPage "3069" @default.
• W2807778587 abstract "Leishmaniasis, Chagas disease, and sleeping sickness affect millions of people worldwide and lead to the death of about 50 000 humans per year. These diseases are caused by the kinetoplastids Leishmania, Trypanosoma cruzi, and Trypanosoma brucei, respectively. These parasites share many general features, including gene conservation, high amino acid identity among proteins, the presence of subcellular structures as glycosomes and the kinetoplastid, and genome architecture, that may make drug development family specific, rather than species-specific, i.e., on the basis of the inhibition of a common, conserved parasite target. However, no optimal molecular targets or broad-spectrum drugs have been identified to date to cure these diseases. Here, the LeishBox from GlaxoSmithKline high-throughput screening, a 192-molecule set of best antileishmanial compounds, based on 1.8 million compounds, was used to identify specific inhibitors of a validated Leishmania target, trypanothione reductase (TR), while analyzing in parallel the homologous human enzyme glutathione reductase (GR). We identified three specific highly potent TR inhibitors and performed docking on the TR solved structure, thereby elucidating the putative molecular basis of TR inhibition. Since TRs from kinetoplastids are well conserved, and these compounds inhibit the growth of Leishmania, Trypanosoma cruzi, and Trypanosoma brucei, the identification of a common validated target may lead to the development of potent antikinetoplastid drugs." @default.
• W2807778587 created "2018-06-21" @default.
• W2807778587 creator A5004465711 @default.
• W2807778587 creator A5007685206 @default.
• W2807778587 creator A5033647374 @default.
• W2807778587 creator A5060832175 @default.
• W2807778587 creator A5062014801 @default.
• W2807778587 creator A5071863016 @default.
• W2807778587 creator A5072838208 @default.
• W2807778587 date "2018-06-13" @default.
• W2807778587 modified "2023-09-24" @default.
• W2807778587 title "Toward a Drug Against All Kinetoplastids: From LeishBox to Specific and Potent Trypanothione Reductase Inhibitors" @default.
• W2807778587 cites W10267725 @default.
• W2807778587 cites W1574993052 @default.
• W2807778587 cites W1753616956 @default.
• W2807778587 cites W1966365776 @default.
• W2807778587 cites W1967441075 @default.
• W2807778587 cites W1979015967 @default.
• W2807778587 cites W2002252754 @default.
• W2807778587 cites W2002861077 @default.
• W2807778587 cites W2002951962 @default.
• W2807778587 cites W2008224161 @default.
• W2807778587 cites W2010015373 @default.
• W2807778587 cites W2019701434 @default.
• W2807778587 cites W2021954594 @default.
• W2807778587 cites W2026722848 @default.
• W2807778587 cites W2032954662 @default.
• W2807778587 cites W2035555452 @default.
• W2807778587 cites W2039704338 @default.
• W2807778587 cites W2053663394 @default.
• W2807778587 cites W2055194259 @default.
• W2807778587 cites W2059299190 @default.
• W2807778587 cites W2068541511 @default.
• W2807778587 cites W2069370060 @default.
• W2807778587 cites W2071334030 @default.
• W2807778587 cites W2074505948 @default.
• W2807778587 cites W2079005105 @default.
• W2807778587 cites W2090150963 @default.
• W2807778587 cites W2091295586 @default.
• W2807778587 cites W2101612703 @default.
• W2807778587 cites W2112711937 @default.
• W2807778587 cites W2114367386 @default.
• W2807778587 cites W2116251790 @default.
• W2807778587 cites W2122428796 @default.
• W2807778587 cites W2123139638 @default.
• W2807778587 cites W2125483721 @default.
• W2807778587 cites W2127431744 @default.
• W2807778587 cites W2132240012 @default.
• W2807778587 cites W2134967712 @default.
• W2807778587 cites W2136382177 @default.
• W2807778587 cites W2137317157 @default.
• W2807778587 cites W2142755221 @default.
• W2807778587 cites W2152855843 @default.
• W2807778587 cites W2154261496 @default.
• W2807778587 cites W2161670666 @default.
• W2807778587 cites W2561615746 @default.
• W2807778587 cites W2577568850 @default.
• W2807778587 cites W622105508 @default.
• W2807778587 doi "https://doi.org/10.1021/acs.molpharmaceut.8b00185" @default.
• W2807778587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29897765" @default.
• W2807778587 hasPublicationYear "2018" @default.
• W2807778587 type Work @default.
• W2807778587 sameAs 2807778587 @default.
• W2807778587 citedByCount "20" @default.
• W2807778587 countsByYear W28077785872019 @default.
• W2807778587 countsByYear W28077785872020 @default.
• W2807778587 countsByYear W28077785872021 @default.
• W2807778587 countsByYear W28077785872022 @default.
• W2807778587 countsByYear W28077785872023 @default.
• W2807778587 crossrefType "journal-article" @default.
• W2807778587 hasAuthorship W2807778587A5004465711 @default.
• W2807778587 hasAuthorship W2807778587A5007685206 @default.
• W2807778587 hasAuthorship W2807778587A5033647374 @default.
• W2807778587 hasAuthorship W2807778587A5060832175 @default.
• W2807778587 hasAuthorship W2807778587A5062014801 @default.
• W2807778587 hasAuthorship W2807778587A5071863016 @default.
• W2807778587 hasAuthorship W2807778587A5072838208 @default.
• W2807778587 hasConcept C104317684 @default.
• W2807778587 hasConcept C112418997 @default.
• W2807778587 hasConcept C136764020 @default.
• W2807778587 hasConcept C159047783 @default.
• W2807778587 hasConcept C181199279 @default.
• W2807778587 hasConcept C2776232752 @default.
• W2807778587 hasConcept C2777625466 @default.
• W2807778587 hasConcept C2779121891 @default.
• W2807778587 hasConcept C2779502636 @default.
• W2807778587 hasConcept C2779549974 @default.
• W2807778587 hasConcept C2781092759 @default.
• W2807778587 hasConcept C41008148 @default.
• W2807778587 hasConcept C55493867 @default.
• W2807778587 hasConcept C70721500 @default.
• W2807778587 hasConcept C71928629 @default.
• W2807778587 hasConcept C74187038 @default.
• W2807778587 hasConcept C86803240 @default.
• W2807778587 hasConceptScore W2807778587C104317684 @default.
• W2807778587 hasConceptScore W2807778587C112418997 @default.
• W2807778587 hasConceptScore W2807778587C136764020 @default.
• W2807778587 hasConceptScore W2807778587C159047783 @default.

• next