Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807788357> ?p ?o ?g. }
- W2807788357 endingPage "3196" @default.
- W2807788357 startingPage "3183" @default.
- W2807788357 abstract "Stress exposure is associated with the pathogenesis of psychiatric disorders, including post-traumatic stress disorder (PTSD) and major depressive disorder (MDD). Here, we show in rodents that chronic stress exposure rapidly and transiently elevates hippocampal expression of Kruppel-like factor 9 (Klf9). Inducible genetic silencing of Klf9 expression in excitatory forebrain neurons in adulthood prior to, but not after, onset of stressor prevented chronic restraint stress (CRS)-induced potentiation of contextual fear acquisition in female mice and chronic corticosterone (CORT) exposure-induced fear generalization in male mice. Klf9 silencing prevented chronic CORT and CRS induced enlargement of dendritic spines in the ventral hippocampus of male and female mice, respectively. KLF9 mRNA density was increased in the anterior dentate gyrus of women, but not men, with more severe recent stressful life events and increased mortality. Thus, Klf9 functions as a stress-responsive transcription factor that mediates circuit and behavioral resilience in a sex-specific manner." @default.
- W2807788357 created "2018-06-21" @default.
- W2807788357 creator A5000618559 @default.
- W2807788357 creator A5021249635 @default.
- W2807788357 creator A5033849430 @default.
- W2807788357 creator A5040216462 @default.
- W2807788357 creator A5040427737 @default.
- W2807788357 creator A5050072689 @default.
- W2807788357 creator A5054705832 @default.
- W2807788357 creator A5056500320 @default.
- W2807788357 creator A5056844070 @default.
- W2807788357 creator A5062262492 @default.
- W2807788357 creator A5065711075 @default.
- W2807788357 creator A5072364904 @default.
- W2807788357 creator A5074887430 @default.
- W2807788357 creator A5076605968 @default.
- W2807788357 date "2018-06-01" @default.
- W2807788357 modified "2023-10-14" @default.
- W2807788357 title "Targeting Kruppel-like Factor 9 in Excitatory Neurons Protects against Chronic Stress-Induced Impairments in Dendritic Spines and Fear Responses" @default.
- W2807788357 cites W1553183704 @default.
- W2807788357 cites W1840860792 @default.
- W2807788357 cites W1920095995 @default.
- W2807788357 cites W1968406762 @default.
- W2807788357 cites W1971231611 @default.
- W2807788357 cites W1980361506 @default.
- W2807788357 cites W1983784678 @default.
- W2807788357 cites W1992284534 @default.
- W2807788357 cites W1994253126 @default.
- W2807788357 cites W1996694057 @default.
- W2807788357 cites W2004434507 @default.
- W2807788357 cites W2014099101 @default.
- W2807788357 cites W2016117011 @default.
- W2807788357 cites W2021199403 @default.
- W2807788357 cites W2023999213 @default.
- W2807788357 cites W2030933765 @default.
- W2807788357 cites W2037060007 @default.
- W2807788357 cites W2039999877 @default.
- W2807788357 cites W2042349177 @default.
- W2807788357 cites W2051005796 @default.
- W2807788357 cites W2056625172 @default.
- W2807788357 cites W2057337104 @default.
- W2807788357 cites W2058073897 @default.
- W2807788357 cites W2060035717 @default.
- W2807788357 cites W2062507609 @default.
- W2807788357 cites W2065029614 @default.
- W2807788357 cites W2071742142 @default.
- W2807788357 cites W2077164692 @default.
- W2807788357 cites W2085594699 @default.
- W2807788357 cites W2087053296 @default.
- W2807788357 cites W2089124259 @default.
- W2807788357 cites W2089242169 @default.
- W2807788357 cites W2090829912 @default.
- W2807788357 cites W2096123613 @default.
- W2807788357 cites W2100230238 @default.
- W2807788357 cites W2100561199 @default.
- W2807788357 cites W2104463303 @default.
- W2807788357 cites W2116629441 @default.
- W2807788357 cites W2117010364 @default.
- W2807788357 cites W2119226169 @default.
- W2807788357 cites W2120629185 @default.
- W2807788357 cites W2121068766 @default.
- W2807788357 cites W2127810309 @default.
- W2807788357 cites W2130630620 @default.
- W2807788357 cites W2140201388 @default.
- W2807788357 cites W2166006462 @default.
- W2807788357 cites W2170684975 @default.
- W2807788357 cites W2171195379 @default.
- W2807788357 cites W2266819934 @default.
- W2807788357 cites W2410082445 @default.
- W2807788357 cites W2470422962 @default.
- W2807788357 cites W2515631058 @default.
- W2807788357 cites W2529186330 @default.
- W2807788357 cites W2534021820 @default.
- W2807788357 cites W2596416526 @default.
- W2807788357 cites W2606878819 @default.
- W2807788357 cites W2751708584 @default.
- W2807788357 cites W2792913800 @default.
- W2807788357 cites W4247333492 @default.
- W2807788357 cites W756325778 @default.
- W2807788357 doi "https://doi.org/10.1016/j.celrep.2018.05.040" @default.
- W2807788357 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7453932" @default.
- W2807788357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29898391" @default.
- W2807788357 hasPublicationYear "2018" @default.
- W2807788357 type Work @default.
- W2807788357 sameAs 2807788357 @default.
- W2807788357 citedByCount "26" @default.
- W2807788357 countsByYear W28077883572019 @default.
- W2807788357 countsByYear W28077883572020 @default.
- W2807788357 countsByYear W28077883572021 @default.
- W2807788357 countsByYear W28077883572022 @default.
- W2807788357 countsByYear W28077883572023 @default.
- W2807788357 crossrefType "journal-article" @default.
- W2807788357 hasAuthorship W2807788357A5000618559 @default.
- W2807788357 hasAuthorship W2807788357A5021249635 @default.
- W2807788357 hasAuthorship W2807788357A5033849430 @default.
- W2807788357 hasAuthorship W2807788357A5040216462 @default.
- W2807788357 hasAuthorship W2807788357A5040427737 @default.
- W2807788357 hasAuthorship W2807788357A5050072689 @default.