Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807807710> ?p ?o ?g. }
- W2807807710 endingPage "589" @default.
- W2807807710 startingPage "579" @default.
- W2807807710 abstract "A series of carbazole-triazole conjugates were designed, synthesized and characterized by IR, NMR, and HRMS spectra. Biological assay showed that most of the synthesized compounds exhibited moderate and even strong antifungal activities, especially 3,6-dibromocarbazolyl triazole 5d displayed excellent inhibitory efficacy against most of the tested fungal strains (MIC = 2-32 μg/mL) and effectively fungicidal ability towards C. albicans, C. tropicals and C. parapsilosis ATCC 22019 (MFC = 4-8 μg/mL). Its combination use with fluconazole could enhance the antifungal efficacy, and compound 5d also did not obviously trigger the development of resistance in C. albicans even after 10 passages. Preliminary mechanism study revealed that the active molecule 5d could depolarize fungal membrane potential and intercalate into DNA to possibly block DNA replication, thus possibly exhibiting its powerful antifungal abilities. Conjugate 5d could interact with HSA, which was constructive for the further design, modification and screening of drug molecules. Docking investigation demonstrated a non-covalent binding of 5d with CYP51 through hydrogen bond and hydrophobicity. These results strongly suggested that compound 5d could act as a potential template for the development of promising antifungal drugs." @default.
- W2807807710 created "2018-06-21" @default.
- W2807807710 creator A5014744448 @default.
- W2807807710 creator A5024287851 @default.
- W2807807710 creator A5031767581 @default.
- W2807807710 creator A5042288248 @default.
- W2807807710 date "2018-07-01" @default.
- W2807807710 modified "2023-10-17" @default.
- W2807807710 title "Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi" @default.
- W2807807710 cites W1990570893 @default.
- W2807807710 cites W1995095396 @default.
- W2807807710 cites W2011853845 @default.
- W2807807710 cites W2016587283 @default.
- W2807807710 cites W2023250166 @default.
- W2807807710 cites W2035178108 @default.
- W2807807710 cites W2037425730 @default.
- W2807807710 cites W2046012592 @default.
- W2807807710 cites W2057080045 @default.
- W2807807710 cites W2069882442 @default.
- W2807807710 cites W2071896576 @default.
- W2807807710 cites W2075606691 @default.
- W2807807710 cites W2088090951 @default.
- W2807807710 cites W2095670129 @default.
- W2807807710 cites W2120773280 @default.
- W2807807710 cites W2133217042 @default.
- W2807807710 cites W2166471470 @default.
- W2807807710 cites W2168439520 @default.
- W2807807710 cites W2209666962 @default.
- W2807807710 cites W2239972278 @default.
- W2807807710 cites W2286307556 @default.
- W2807807710 cites W2293635874 @default.
- W2807807710 cites W2315479558 @default.
- W2807807710 cites W2325789462 @default.
- W2807807710 cites W2328059730 @default.
- W2807807710 cites W2331319068 @default.
- W2807807710 cites W2338600902 @default.
- W2807807710 cites W2341742415 @default.
- W2807807710 cites W2342392807 @default.
- W2807807710 cites W2343041222 @default.
- W2807807710 cites W2410361991 @default.
- W2807807710 cites W2487615858 @default.
- W2807807710 cites W2527048539 @default.
- W2807807710 cites W2528427270 @default.
- W2807807710 cites W2570398663 @default.
- W2807807710 cites W2577937834 @default.
- W2807807710 cites W2589030129 @default.
- W2807807710 cites W2592329802 @default.
- W2807807710 cites W2593825155 @default.
- W2807807710 cites W2598379368 @default.
- W2807807710 cites W2607304550 @default.
- W2807807710 cites W2612278270 @default.
- W2807807710 cites W2613530366 @default.
- W2807807710 cites W2626993113 @default.
- W2807807710 cites W2735469797 @default.
- W2807807710 cites W2745306840 @default.
- W2807807710 cites W2764102065 @default.
- W2807807710 cites W2766695995 @default.
- W2807807710 cites W2768006830 @default.
- W2807807710 cites W2772925837 @default.
- W2807807710 cites W2774185606 @default.
- W2807807710 cites W2781516573 @default.
- W2807807710 cites W2784078304 @default.
- W2807807710 cites W2786700242 @default.
- W2807807710 cites W2790864545 @default.
- W2807807710 cites W4243529542 @default.
- W2807807710 cites W637549772 @default.
- W2807807710 cites W961499025 @default.
- W2807807710 doi "https://doi.org/10.1016/j.ejmech.2018.06.022" @default.
- W2807807710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29913383" @default.
- W2807807710 hasPublicationYear "2018" @default.
- W2807807710 type Work @default.
- W2807807710 sameAs 2807807710 @default.
- W2807807710 citedByCount "57" @default.
- W2807807710 countsByYear W28078077102018 @default.
- W2807807710 countsByYear W28078077102019 @default.
- W2807807710 countsByYear W28078077102020 @default.
- W2807807710 countsByYear W28078077102021 @default.
- W2807807710 countsByYear W28078077102022 @default.
- W2807807710 countsByYear W28078077102023 @default.
- W2807807710 crossrefType "journal-article" @default.
- W2807807710 hasAuthorship W2807807710A5014744448 @default.
- W2807807710 hasAuthorship W2807807710A5024287851 @default.
- W2807807710 hasAuthorship W2807807710A5031767581 @default.
- W2807807710 hasAuthorship W2807807710A5042288248 @default.
- W2807807710 hasConcept C134306372 @default.
- W2807807710 hasConcept C159110408 @default.
- W2807807710 hasConcept C164718446 @default.
- W2807807710 hasConcept C178790620 @default.
- W2807807710 hasConcept C185592680 @default.
- W2807807710 hasConcept C197336794 @default.
- W2807807710 hasConcept C21951064 @default.
- W2807807710 hasConcept C2776127813 @default.
- W2807807710 hasConcept C2777907353 @default.
- W2807807710 hasConcept C2779548794 @default.
- W2807807710 hasConcept C2780651595 @default.
- W2807807710 hasConcept C2780917455 @default.
- W2807807710 hasConcept C33923547 @default.
- W2807807710 hasConcept C41685203 @default.