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• W2807820171 endingPage "1800927" @default.
• W2807820171 startingPage "1800927" @default.
• W2807820171 abstract "Neuromodulation tools are useful to decipher and modulate neural circuitries implicated in functions and diseases. Existing electrical and chemical tools cannot offer specific neural modulation while optogenetics has limitations for deep tissue interfaces, which might be overcome by miniaturized optoelectronic devices in the future. Here, a 3D magnetic hyaluronic hydrogel is described that offers noninvasive neuromodulation via magnetomechanical stimulation of primary dorsal root ganglion (DRG) neurons. The hydrogel shares similar biochemical and biophysical properties as the extracellular matrix of spinal cord, facilitating healthy growth of functional neurites and expression of excitatory and inhibitory ion channels. By testing with different neurotoxins, and micropillar substrate deflections with electrophysical recordings, it is found that acute magnetomechanical stimulation induces calcium influx in DRG neurons primarily via endogenous, mechanosensitive TRPV4 and PIEZO2 channels. Next, capitalizing on the receptor adaptation characteristic of DRG neurons, chronic magnetomechanical stimulation is performed and found that it reduces the expression of PIEZO2 channels, which can be useful for modulating pain where mechanosensitive channels are typically overexpressed. A general strategy is thus offered for neuroscientists and material scientists to fabricate 3D magnetic biomaterials tailored to different types of excitable cells for remote magnetomechanical modulation." @default.
• W2807820171 created "2018-06-21" @default.
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• W2807820171 date "2018-06-10" @default.
• W2807820171 modified "2023-10-02" @default.
• W2807820171 title "A 3D Magnetic Hyaluronic Acid Hydrogel for Magnetomechanical Neuromodulation of Primary Dorsal Root Ganglion Neurons" @default.
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• W2807820171 doi "https://doi.org/10.1002/adma.201800927" @default.
• W2807820171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29888402" @default.
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