FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2807881229> ?p ?o ?g. }

• W2807881229 abstract "Background Neurological involvement is one of the most serious complications in Behcet’s disease (BD). Objectives To investigate the clinical characteristics of parenchymal neuro-Behcet’s Disease (pNBD). Methods We retrospectively reviewed all the medical records of BD patients who were admitted to our institute between 2000 and 2016. The diagnosis of NBD was based on the 2014 International Consensus criteria for NBD. 1 Eighty-four BD patients without neurological involvement were randomly matched by sex and age as control. Results 42 patients (25 male and 17 female) with pNBD accounted for 4.2% of the 1009 hospitalised BD patients during that period. The mean age at BD onset and at neurological onset was (30.1±11.1 years old and (35.3±12.1 years old, respectively. The majority of patients developed neurological symptoms after other initial systemic symptoms of BD in a median period of 2 months (range from 0–49). Neurological onset was concomitant with the onset of BD in 6 cases (14.3%). The most frequent location was brainstem (23/42, 54.8%). Spinal cord involvement was presented in five cases, in which four with cervical cord involved. 13 cases suffered from multiple lesions. Pyramidal (21/42, 50.0%) and headache (14/42, 33.3%) were the most common manifestations of pNBD. Lumbar puncture was performed in 40 patients, in which 80% (32/40) of patients had normal pressure and 55% (22/40) had elevated protein levels ((0.51±0.24) g/L). Compared with the controls, the prevelance of ocular involvement (uveitis, retinal vasculitis, scleritis) was significantly higher in pNBD (35.7%) (p=0.041, OR=2.36, 95%CI=1.03–5.44) (table 1). Cranial MRI in 32 patients showed the lesions were mainly in the midline structures, including brainstem (22/42, 52.4%), periventricular (13/42, 31.0%), centrum semiovale (8/42, 19.0%). Typically, the lesions were in hypersignal in T2. All pNBD patients recevied corticosteroids (≥1 mg/kg/d) and 23 patients (54.8%) received the pulse dose (1 g/d). Cyclophosphamide was the most commonly used immunosuppressant (39/42) and 10 cases took more than one immunosuppressants (including methotrexate and azathioprine). Biological agents were administrated in six refractory pNBD patients, including Infliximab in 4 cases, Tocilizumab in 1 case, and Interferon-α2a in 1 case. Intrathecally injection of dexamethasone 10 mg and methotrexate 10 mg was given to 28 patients. With a median follow-up of 28 months (4 to 156 months), 22 patients (52.4%) achieved clinical improvements, while 10 patients (23.8%) relapsed and 4 patients died (the mortality was 9.5%). Six patients lost to follow up. Conclusions The parenchymal neurological involvement is a rare complication of BD with a high mortality. Its most frequent location is brainstem. Ocular involvement is a risk factor for pNBD. Early identification and active treatment are vital for a good prognosis. References [1] Kalra S, Silman A, Akman-Demir G, et al. Diagnosis and management of Neuro-Behcet’s disease: international consensus recommendations. J Neurol. 2014Sep;261(9):1662–76. Disclosure of Interest None declared" @default.
• W2807881229 created "2018-06-21" @default.
• W2807881229 creator A5000330024 @default.
• W2807881229 creator A5005451961 @default.
• W2807881229 creator A5008382096 @default.
• W2807881229 creator A5019045319 @default.
• W2807881229 creator A5026841517 @default.
• W2807881229 creator A5059120169 @default.
• W2807881229 date "2018-06-01" @default.
• W2807881229 modified "2023-09-27" @default.
• W2807881229 title "FRI0492 Clinical characteristics of parenchymal neuro-behcet’s disease: a retrospective analysis" @default.
• W2807881229 doi "https://doi.org/10.1136/annrheumdis-2018-eular.4580" @default.
• W2807881229 hasPublicationYear "2018" @default.
• W2807881229 type Work @default.
• W2807881229 sameAs 2807881229 @default.
• W2807881229 citedByCount "0" @default.
• W2807881229 crossrefType "proceedings-article" @default.
• W2807881229 hasAuthorship W2807881229A5000330024 @default.
• W2807881229 hasAuthorship W2807881229A5005451961 @default.
• W2807881229 hasAuthorship W2807881229A5008382096 @default.
• W2807881229 hasAuthorship W2807881229A5019045319 @default.
• W2807881229 hasAuthorship W2807881229A5026841517 @default.
• W2807881229 hasAuthorship W2807881229A5059120169 @default.
• W2807881229 hasBestOaLocation W28078812291 @default.
• W2807881229 hasConcept C118552586 @default.
• W2807881229 hasConcept C126322002 @default.
• W2807881229 hasConcept C141071460 @default.
• W2807881229 hasConcept C167135981 @default.
• W2807881229 hasConcept C187212893 @default.
• W2807881229 hasConcept C195910791 @default.
• W2807881229 hasConcept C2779134260 @default.
• W2807881229 hasConcept C2779384505 @default.
• W2807881229 hasConcept C2779651940 @default.
• W2807881229 hasConcept C2780066322 @default.
• W2807881229 hasConcept C2780775167 @default.
• W2807881229 hasConcept C2781428731 @default.
• W2807881229 hasConcept C44575665 @default.
• W2807881229 hasConcept C71924100 @default.
• W2807881229 hasConceptScore W2807881229C118552586 @default.
• W2807881229 hasConceptScore W2807881229C126322002 @default.
• W2807881229 hasConceptScore W2807881229C141071460 @default.
• W2807881229 hasConceptScore W2807881229C167135981 @default.
• W2807881229 hasConceptScore W2807881229C187212893 @default.
• W2807881229 hasConceptScore W2807881229C195910791 @default.
• W2807881229 hasConceptScore W2807881229C2779134260 @default.
• W2807881229 hasConceptScore W2807881229C2779384505 @default.
• W2807881229 hasConceptScore W2807881229C2779651940 @default.
• W2807881229 hasConceptScore W2807881229C2780066322 @default.
• W2807881229 hasConceptScore W2807881229C2780775167 @default.
• W2807881229 hasConceptScore W2807881229C2781428731 @default.
• W2807881229 hasConceptScore W2807881229C44575665 @default.
• W2807881229 hasConceptScore W2807881229C71924100 @default.
• W2807881229 hasLocation W28078812291 @default.
• W2807881229 hasOpenAccess W2807881229 @default.
• W2807881229 hasPrimaryLocation W28078812291 @default.
• W2807881229 hasRelatedWork W1979158448 @default.
• W2807881229 hasRelatedWork W1995779063 @default.
• W2807881229 hasRelatedWork W2040100404 @default.
• W2807881229 hasRelatedWork W2068805228 @default.
• W2807881229 hasRelatedWork W2115894703 @default.
• W2807881229 hasRelatedWork W2183155075 @default.
• W2807881229 hasRelatedWork W2319265495 @default.
• W2807881229 hasRelatedWork W2412698021 @default.
• W2807881229 hasRelatedWork W2413616662 @default.
• W2807881229 hasRelatedWork W2416828370 @default.
• W2807881229 hasRelatedWork W2550598370 @default.
• W2807881229 hasRelatedWork W2910662160 @default.
• W2807881229 hasRelatedWork W2952627645 @default.
• W2807881229 hasRelatedWork W2952707407 @default.
• W2807881229 hasRelatedWork W2973148488 @default.
• W2807881229 hasRelatedWork W2987761427 @default.
• W2807881229 hasRelatedWork W3030464350 @default.
• W2807881229 hasRelatedWork W3165804850 @default.
• W2807881229 hasRelatedWork W41718336 @default.
• W2807881229 hasRelatedWork W49413111 @default.
• W2807881229 isParatext "false" @default.
• W2807881229 isRetracted "false" @default.
• W2807881229 magId "2807881229" @default.
• W2807881229 workType "article" @default.