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- W2807882663 abstract "目的:观察噪声暴露后不同时间豚鼠耳蜗内毛细胞(inner hair cell,IHC)谷氨酸样免疫反应(glutamate-like immunoreactivity,Glu-IR)的变化.方法:将实验动物随机分为正常对照组与噪声暴露后即刻、8小时、1天、3天和7天组.噪声暴露前,先破坏全部动物的右耳鼓膜,并用磷酸锌牙科水泥堵塞右侧外耳道,然后将实验各组在准自由声场中暴露于120dBLp1/3倍频程的4kHz窄带声中4小时,造成左侧(单侧)耳蜗噪声损害的动物模型.用SP法对耳蜗Corti器半薄切片作谷氨酸样免疫细胞化学染色,用计算机图像分析系统测量耳蜗IHC中Glu-IR的平均光密度(average optical density,AOD)值.结果:正常对照组,豚鼠两侧耳蜗IHC中Glu-IR的AOD值无差异(P>0.05);在噪声暴露后即刻组,豚鼠左侧耳蜗IHC中Glu-IR的AOD值较右侧高(P 0.05).结论:噪声暴露后耳蜗IHC中Glu-IR经过一个从增强-减弱-恢复动态变化过程." @default.
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- W2807882663 date "2002-01-01" @default.
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- W2807882663 title "The dynamic changes of glutamate-like immunoreactivity in cochleae inner hair cells of guinea pigs after noise exposure" @default.
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