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- W2807890372 abstract "Abstract Several studies have suggested that bipolar disorder has progressive characteristics. The term “neuroprogression” has been used to define the disease process acceleration and its underlying factors, such as changes in peripheral biomarkers, cognitive functions, neuroimaging, and functionality, which appear to varying degrees depending on disorder evolution stage. The long-term course of bipolar disorder patients commonly presents with high degrees of impairment, progressive decrease in duration of euthymic periods and inversely increased mood episodes, as well as poor response to psychosocial and pharmacological treatments. The mechanisms underlying the pathophysiological alterations observed in the late stages of neuroprogression are still unknown. The most described theories are “Kindling,” Allostatic Load (AL), and Accelerated Aging (AA). Clinical staging is widely used in many medical specialties, for determining the stage of development of a disease. Several divisions of bipolar disorder phases arise from staging models. The use of staging models in bipolar disorder may lead to early detection, possible prevention, and adoption of social and functional assistance strategies for patients. However, primary prevention has been relatively understudied in bipolar disorder, thus reinforcing the need for consolidation of this field of study." @default.
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- W2807890372 date "2018-01-01" @default.
- W2807890372 modified "2023-09-27" @default.
- W2807890372 title "Staging models and neuroprogression in bipolar disorder" @default.
- W2807890372 doi "https://doi.org/10.1016/b978-0-12-812347-8.00002-6" @default.
- W2807890372 hasPublicationYear "2018" @default.
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