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- W2807900281 endingPage "1526" @default.
- W2807900281 startingPage "1517" @default.
- W2807900281 abstract "In total, 80%-90% of Hodgkin's lymphoma (HL) patients are curable with combination chemoradiotherapy. Due to improvements in therapeutic strategies, 50% of all relapsed/refractory patients may undergo complete clinical responses and have long-term survival. Treatment options for HL are effective, but may have a negative impact on post-chemotherapy fertility. Thus, cryopreservation of semen prior to treatment is recommended for male patients. For female patients, assisted reproductive techniques (ART) consult and fertility preservation should be offered as a therapeutical option. In the last years, new targeted molecules have been available for HL treatment. These new drugs showed a high rate of overall responses in the setting of heavily pretreated patients, most of them in relapse after autologous stem cell transplantation, a group previously considered very poor risk. Up to 50% of patients have a complete response and an improved overall survival. Future studies will address the usefulness of novel molecules as a frontline therapy. Considering the high response and survival rates with monoclonal antibody-based therapeutics, fertility has become a concerning issue for long-term HL survivors. As progress has been made regarding ART, with the rigorous steps planned for HL patients, more survivors will become parents." @default.
- W2807900281 created "2018-06-21" @default.
- W2807900281 creator A5014550089 @default.
- W2807900281 creator A5027491159 @default.
- W2807900281 creator A5040864132 @default.
- W2807900281 creator A5041293121 @default.
- W2807900281 date "2018-06-01" @default.
- W2807900281 modified "2023-09-30" @default.
- W2807900281 title "Fertility preservation in Hodgkin’s lymphoma patients that undergo targeted molecular therapies: an important step forward from the chemotherapy era" @default.
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