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- W2807901800 abstract "Despite high response rates to initial therapy, relapses are common in patients with small-cell lung cancer (SCLC). Systemic therapy after first-line failure remains important in the treatment paradigm of SCLC. Reinitiation of a previously administered first-line chemotherapy regimen is recommended for relapse > 6 months from completion of initial therapy. For relapse ≤ 6 months of initial therapy, sequential therapy with single agents is recommended. Clinical trial enrollment should be considered at all stages of treatment of SCLC. This review highlights the available treatment options in relapsed SCLC. In particular, we focus on prospective clinical trials demonstrating activity for the most commonly used agents in this setting. We end with a discussion on future directions and emerging targets with potential to improve outcomes in relapsed SCLC." @default.
- W2807901800 created "2018-06-21" @default.
- W2807901800 creator A5003826371 @default.
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- W2807901800 date "2018-06-01" @default.
- W2807901800 modified "2023-10-17" @default.
- W2807901800 title "Managing Patients With Relapsed Small-Cell Lung Cancer" @default.
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- W2807901800 doi "https://doi.org/10.1200/jop.18.00204" @default.
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