FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808020051> ?p ?o ?g. }

• W2808020051 endingPage "342" @default.
• W2808020051 startingPage "331" @default.
• W2808020051 abstract "HIMF (hypoxia-induced mitogenic factor/found in inflammatory zone 1/resistin like α) is a secretory and cytokine-like protein and serves as a critical stimulator of hypoxia-induced pulmonary hypertension. With a role for HIMF in heart disease unknown, we explored the possible roles for HIMF in cardiac hypertrophy by overexpressing and knocking down HIMF in cardiomyocytes and characterizing HIMF gene ( himf ) knockout mice. We found that HIMF mRNA and protein levels were upregulated in phenylephrine-stimulated cardiomyocyte hypertrophy and our mouse model of transverse aortic constriction–induced cardiac hypertrophy, as well as in human hearts with dilated cardiomyopathy. Furthermore, HIMF overexpression could induce cardiomyocyte hypertrophy, as characterized by elevated protein expression of hypertrophic biomarkers (ANP [atrial natriuretic peptide] and β-MHC [myosin heavy chain-β]) and increased cell-surface area compared with controls. Conversely, HIMF knockdown prevented phenylephrine-induced cardiomyocyte hypertrophy and himf ablation in knockout mice significantly attenuated transverse aortic constriction–induced hypertrophic remodeling and cardiac dysfunction. HIMF overexpression increased the cytosolic Ca 2+ concentration and activated the CaN–NFAT (calcineurin–nuclear factor of activated T cell) and MAPK (mitogen-activated protein kinase) pathways; this effect could be prevented by reducing cytosolic Ca 2+ concentration with L-type Ca 2+ channel blocker nifedipine or inhibiting the CaSR (Ca 2+ sensing receptor) with Calhex 231. Furthermore, HIMF overexpression increased HIF-1α (hypoxia-inducible factor) expression in neonatal rat ventricular myocytes, and HIMF knockout inhibited HIF-1α upregulation in transverse aortic constriction mice. Knockdown of HIF-1α attenuated HIMF-induced cardiomyocyte hypertrophy. In conclusion, HIMF has a critical role in the development of cardiac hypertrophy, and targeting HIMF may represent a potential therapeutic strategy." @default.
• W2808020051 created "2018-06-21" @default.
• W2808020051 creator A5021138454 @default.
• W2808020051 creator A5030921116 @default.
• W2808020051 creator A5033001727 @default.
• W2808020051 creator A5068634489 @default.
• W2808020051 creator A5070151668 @default.
• W2808020051 creator A5085352453 @default.
• W2808020051 creator A5090449363 @default.
• W2808020051 creator A5090541429 @default.
• W2808020051 date "2018-08-01" @default.
• W2808020051 modified "2023-10-01" @default.
• W2808020051 title "Hypoxia-Induced Mitogenic Factor Promotes Cardiac Hypertrophy via Calcium-Dependent and Hypoxia-Inducible Factor-1α Mechanisms" @default.
• W2808020051 cites W1482605042 @default.
• W2808020051 cites W1504007488 @default.
• W2808020051 cites W1567439183 @default.
• W2808020051 cites W1983988934 @default.
• W2808020051 cites W1993468618 @default.
• W2808020051 cites W2010136682 @default.
• W2808020051 cites W2019823288 @default.
• W2808020051 cites W2025826819 @default.
• W2808020051 cites W2027913038 @default.
• W2808020051 cites W2041043528 @default.
• W2808020051 cites W2050824263 @default.
• W2808020051 cites W2051001217 @default.
• W2808020051 cites W2065206903 @default.
• W2808020051 cites W2066475426 @default.
• W2808020051 cites W2066598065 @default.
• W2808020051 cites W2072627829 @default.
• W2808020051 cites W2072727898 @default.
• W2808020051 cites W2088131370 @default.
• W2808020051 cites W2091592969 @default.
• W2808020051 cites W2092224692 @default.
• W2808020051 cites W2092429129 @default.
• W2808020051 cites W2103790014 @default.
• W2808020051 cites W2110244190 @default.
• W2808020051 cites W2115574360 @default.
• W2808020051 cites W2118157159 @default.
• W2808020051 cites W2122798447 @default.
• W2808020051 cites W2124514079 @default.
• W2808020051 cites W2127952198 @default.
• W2808020051 cites W2128337755 @default.
• W2808020051 cites W2134966197 @default.
• W2808020051 cites W2135781117 @default.
• W2808020051 cites W2146684396 @default.
• W2808020051 cites W2152841886 @default.
• W2808020051 cites W2168858690 @default.
• W2808020051 cites W2179762441 @default.
• W2808020051 cites W2431126783 @default.
• W2808020051 cites W2599174518 @default.
• W2808020051 cites W2740349381 @default.
• W2808020051 cites W2743096497 @default.
• W2808020051 cites W2746800304 @default.
• W2808020051 cites W4293258641 @default.
• W2808020051 cites W647542028 @default.
• W2808020051 doi "https://doi.org/10.1161/hypertensionaha.118.10845" @default.
• W2808020051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29891648" @default.
• W2808020051 hasPublicationYear "2018" @default.
• W2808020051 type Work @default.
• W2808020051 sameAs 2808020051 @default.
• W2808020051 citedByCount "49" @default.
• W2808020051 countsByYear W28080200512019 @default.
• W2808020051 countsByYear W28080200512020 @default.
• W2808020051 countsByYear W28080200512021 @default.
• W2808020051 countsByYear W28080200512022 @default.
• W2808020051 countsByYear W28080200512023 @default.
• W2808020051 crossrefType "journal-article" @default.
• W2808020051 hasAuthorship W2808020051A5021138454 @default.
• W2808020051 hasAuthorship W2808020051A5030921116 @default.
• W2808020051 hasAuthorship W2808020051A5033001727 @default.
• W2808020051 hasAuthorship W2808020051A5068634489 @default.
• W2808020051 hasAuthorship W2808020051A5070151668 @default.
• W2808020051 hasAuthorship W2808020051A5085352453 @default.
• W2808020051 hasAuthorship W2808020051A5090449363 @default.
• W2808020051 hasAuthorship W2808020051A5090541429 @default.
• W2808020051 hasBestOaLocation W28080200511 @default.
• W2808020051 hasConcept C104317684 @default.
• W2808020051 hasConcept C126322002 @default.
• W2808020051 hasConcept C127561419 @default.
• W2808020051 hasConcept C128057223 @default.
• W2808020051 hasConcept C134018914 @default.
• W2808020051 hasConcept C167414201 @default.
• W2808020051 hasConcept C173396325 @default.
• W2808020051 hasConcept C178790620 @default.
• W2808020051 hasConcept C185592680 @default.
• W2808020051 hasConcept C189938988 @default.
• W2808020051 hasConcept C190283241 @default.
• W2808020051 hasConcept C2777952589 @default.
• W2808020051 hasConcept C2778271984 @default.
• W2808020051 hasConcept C2911091166 @default.
• W2808020051 hasConcept C3018791406 @default.
• W2808020051 hasConcept C540031477 @default.
• W2808020051 hasConcept C55493867 @default.
• W2808020051 hasConcept C71924100 @default.
• W2808020051 hasConcept C7836513 @default.
• W2808020051 hasConcept C84393581 @default.
• W2808020051 hasConcept C86803240 @default.
• W2808020051 hasConceptScore W2808020051C104317684 @default.

• next