Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808033976> ?p ?o ?g. }
- W2808033976 endingPage "119" @default.
- W2808033976 startingPage "112" @default.
- W2808033976 abstract "The ubiquitin-related protein NEDD8 is conjugated and deconjugated to and from proteins in processes related to ubiquitin conjugation and deconjugation. Neddylation is a well-studied posttranslational modification of Cullin-RING E3 ligases (CRLs). Biochemical and structural studies aiming at understanding the role of NEDD8 in CRL function have now resulted in a convincing model of how neddylation and deneddylation antagonistically regulate CRL stability, conformation, activity as well as degradation substrate receptor exchange. Studies of the Arabidopsis thaliana deneddylation-deficient den1 mutant led to the identification of many low abundant, non-Cullin NEDD8 conjugates. Examination of neddylated AUXIN RESISTANT1 (AXR1), a prominent neddylated protein in den1, suggests, however, that AXR1 neddylation may be an auto-catalytic side-reaction of Cullin-targeted neddylation and that DEN1 may serve to antagonize non-productive, auto-neddylation from substrates to provide free NEDD8 for CRL regulation." @default.
- W2808033976 created "2018-06-21" @default.
- W2808033976 creator A5055776595 @default.
- W2808033976 date "2018-10-01" @default.
- W2808033976 modified "2023-09-25" @default.
- W2808033976 title "NEDD8 — its role in the regulation of Cullin-RING ligases" @default.
- W2808033976 cites W1902302867 @default.
- W2808033976 cites W1964909962 @default.
- W2808033976 cites W1968887194 @default.
- W2808033976 cites W1972633502 @default.
- W2808033976 cites W1975053636 @default.
- W2808033976 cites W1983407078 @default.
- W2808033976 cites W1985693648 @default.
- W2808033976 cites W1986128576 @default.
- W2808033976 cites W1991183072 @default.
- W2808033976 cites W1992831066 @default.
- W2808033976 cites W1996545881 @default.
- W2808033976 cites W2007422896 @default.
- W2808033976 cites W2008277483 @default.
- W2808033976 cites W2013057562 @default.
- W2808033976 cites W2014012552 @default.
- W2808033976 cites W2016260355 @default.
- W2808033976 cites W2021858754 @default.
- W2808033976 cites W2025861321 @default.
- W2808033976 cites W2029890158 @default.
- W2808033976 cites W2046510462 @default.
- W2808033976 cites W2053763318 @default.
- W2808033976 cites W2053882361 @default.
- W2808033976 cites W2056998476 @default.
- W2808033976 cites W2066745745 @default.
- W2808033976 cites W2073995995 @default.
- W2808033976 cites W2074676459 @default.
- W2808033976 cites W2082672730 @default.
- W2808033976 cites W2084850514 @default.
- W2808033976 cites W2086955443 @default.
- W2808033976 cites W2094021381 @default.
- W2808033976 cites W2098614435 @default.
- W2808033976 cites W2099443464 @default.
- W2808033976 cites W2101913031 @default.
- W2808033976 cites W2103448931 @default.
- W2808033976 cites W2106969933 @default.
- W2808033976 cites W2108341815 @default.
- W2808033976 cites W2113174490 @default.
- W2808033976 cites W2120668188 @default.
- W2808033976 cites W2121477827 @default.
- W2808033976 cites W2130635437 @default.
- W2808033976 cites W2134176459 @default.
- W2808033976 cites W2135339359 @default.
- W2808033976 cites W2140219059 @default.
- W2808033976 cites W2140321845 @default.
- W2808033976 cites W2140325860 @default.
- W2808033976 cites W2143543985 @default.
- W2808033976 cites W2146253911 @default.
- W2808033976 cites W2149650548 @default.
- W2808033976 cites W2151689667 @default.
- W2808033976 cites W2155421702 @default.
- W2808033976 cites W2165902959 @default.
- W2808033976 cites W2167686263 @default.
- W2808033976 cites W2168588242 @default.
- W2808033976 cites W2313629931 @default.
- W2808033976 cites W2327577222 @default.
- W2808033976 cites W2508968739 @default.
- W2808033976 cites W2571953220 @default.
- W2808033976 cites W2755866416 @default.
- W2808033976 cites W2766427223 @default.
- W2808033976 cites W2772224272 @default.
- W2808033976 cites W2774864460 @default.
- W2808033976 cites W2791421524 @default.
- W2808033976 doi "https://doi.org/10.1016/j.pbi.2018.05.017" @default.
- W2808033976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29909289" @default.
- W2808033976 hasPublicationYear "2018" @default.
- W2808033976 type Work @default.
- W2808033976 sameAs 2808033976 @default.
- W2808033976 citedByCount "51" @default.
- W2808033976 countsByYear W28080339762019 @default.
- W2808033976 countsByYear W28080339762020 @default.
- W2808033976 countsByYear W28080339762021 @default.
- W2808033976 countsByYear W28080339762022 @default.
- W2808033976 countsByYear W28080339762023 @default.
- W2808033976 crossrefType "journal-article" @default.
- W2808033976 hasAuthorship W2808033976A5055776595 @default.
- W2808033976 hasConcept C104317684 @default.
- W2808033976 hasConcept C134459356 @default.
- W2808033976 hasConcept C181199279 @default.
- W2808033976 hasConcept C25602115 @default.
- W2808033976 hasConcept C2776714187 @default.
- W2808033976 hasConcept C2778567606 @default.
- W2808033976 hasConcept C2778884322 @default.
- W2808033976 hasConcept C2779231659 @default.
- W2808033976 hasConcept C2908868211 @default.
- W2808033976 hasConcept C2908981932 @default.
- W2808033976 hasConcept C45005369 @default.
- W2808033976 hasConcept C55493867 @default.
- W2808033976 hasConcept C86803240 @default.
- W2808033976 hasConcept C95444343 @default.
- W2808033976 hasConceptScore W2808033976C104317684 @default.
- W2808033976 hasConceptScore W2808033976C134459356 @default.
- W2808033976 hasConceptScore W2808033976C181199279 @default.