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- W2808040568 endingPage "90" @default.
- W2808040568 startingPage "63" @default.
- W2808040568 abstract "Oligodendrocytes are specialized glial cells that myelinate central nervous system (CNS) axons. Historically, it was believed that the primary role of myelin was to compactly ensheath axons, providing the insulation necessary for rapid signal conduction. However, mounting evidence demonstrates the dynamic importance of myelin and oligodendrocytes, including providing metabolic support to neurons and regulating axon protein distribution. As such, the development and maintenance of oligodendrocytes and myelin are integral to preserving CNS homeostasis and supporting proper functioning of widespread neural networks. Environmental signals are critical for proper oligodendrocyte lineage cell progression and their capacity to form functional compact myelin; these signals are markedly disturbed by injury to the CNS, which may compromise endogenous myelin repair capabilities. This review outlines some key environmental factors that drive myelin formation during development and compares that to the primary factors that define a CNS injury milieu. We aim to identify developmental factors disrupted after CNS trauma as well as pathogenic factors that negatively impact oligodendrocyte lineage cells, as these are potential therapeutic targets to promote myelin repair after injury or disease." @default.
- W2808040568 created "2018-06-21" @default.
- W2808040568 creator A5041415357 @default.
- W2808040568 creator A5057127911 @default.
- W2808040568 creator A5072119666 @default.
- W2808040568 date "2018-06-11" @default.
- W2808040568 modified "2023-09-26" @default.
- W2808040568 title "To Be or Not to Be: Environmental Factors that Drive Myelin Formation during Development and after CNS Trauma" @default.
- W2808040568 cites W1140975977 @default.
- W2808040568 cites W137197963 @default.
- W2808040568 cites W1502312172 @default.
- W2808040568 cites W1504001606 @default.
- W2808040568 cites W1509596990 @default.
- W2808040568 cites W1530778223 @default.
- W2808040568 cites W1543519398 @default.
- W2808040568 cites W1554606831 @default.
- W2808040568 cites W1581820640 @default.
- W2808040568 cites W1592789336 @default.
- W2808040568 cites W1608092431 @default.
- W2808040568 cites W1609101809 @default.
- W2808040568 cites W1689660630 @default.
- W2808040568 cites W1765057352 @default.
- W2808040568 cites W1847979911 @default.
- W2808040568 cites W1863108431 @default.
- W2808040568 cites W1894143964 @default.
- W2808040568 cites W1900556344 @default.
- W2808040568 cites W1902612341 @default.
- W2808040568 cites W1948282121 @default.
- W2808040568 cites W1966708171 @default.
- W2808040568 cites W1966879473 @default.
- W2808040568 cites W1967529127 @default.
- W2808040568 cites W1968451659 @default.
- W2808040568 cites W1968998853 @default.
- W2808040568 cites W1969119054 @default.
- W2808040568 cites W1969326097 @default.
- W2808040568 cites W1969647408 @default.
- W2808040568 cites W1971671659 @default.
- W2808040568 cites W1972045793 @default.
- W2808040568 cites W1972553563 @default.
- W2808040568 cites W1972754612 @default.
- W2808040568 cites W1973375828 @default.
- W2808040568 cites W1974172728 @default.
- W2808040568 cites W1974967725 @default.
- W2808040568 cites W1976152949 @default.
- W2808040568 cites W1976273488 @default.
- W2808040568 cites W1976527218 @default.
- W2808040568 cites W1977213877 @default.
- W2808040568 cites W1978880296 @default.
- W2808040568 cites W1979670158 @default.
- W2808040568 cites W1980286364 @default.
- W2808040568 cites W1981030744 @default.
- W2808040568 cites W1982598770 @default.
- W2808040568 cites W1982691004 @default.
- W2808040568 cites W1983326868 @default.
- W2808040568 cites W1983868522 @default.
- W2808040568 cites W1986094842 @default.
- W2808040568 cites W1986668504 @default.
- W2808040568 cites W1987885030 @default.
- W2808040568 cites W1988007772 @default.
- W2808040568 cites W1988982755 @default.
- W2808040568 cites W1989430490 @default.
- W2808040568 cites W1990964778 @default.
- W2808040568 cites W1991388070 @default.
- W2808040568 cites W1991832674 @default.
- W2808040568 cites W1992245559 @default.
- W2808040568 cites W1996935748 @default.
- W2808040568 cites W1997035797 @default.
- W2808040568 cites W1997233742 @default.
- W2808040568 cites W1997557431 @default.
- W2808040568 cites W1997620569 @default.
- W2808040568 cites W1997945370 @default.
- W2808040568 cites W1998009350 @default.
- W2808040568 cites W1998475020 @default.
- W2808040568 cites W2002367555 @default.
- W2808040568 cites W2004161433 @default.
- W2808040568 cites W2004219852 @default.
- W2808040568 cites W2005272267 @default.
- W2808040568 cites W2005416260 @default.
- W2808040568 cites W2005578607 @default.
- W2808040568 cites W2005802819 @default.
- W2808040568 cites W2005984136 @default.
- W2808040568 cites W2006257074 @default.
- W2808040568 cites W2007544675 @default.
- W2808040568 cites W2008188282 @default.
- W2808040568 cites W2010121754 @default.
- W2808040568 cites W2010887753 @default.
- W2808040568 cites W2010936746 @default.
- W2808040568 cites W2011353038 @default.
- W2808040568 cites W2011557383 @default.
- W2808040568 cites W2011725743 @default.
- W2808040568 cites W2011792758 @default.
- W2808040568 cites W2011937563 @default.
- W2808040568 cites W2013611803 @default.
- W2808040568 cites W2013681684 @default.
- W2808040568 cites W2013997823 @default.
- W2808040568 cites W2015041369 @default.
- W2808040568 cites W2015066175 @default.
- W2808040568 cites W2021898378 @default.