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- W2808041642 startingPage "761" @default.
- W2808041642 abstract "Lysosomes are highly dynamic organelles that can move rapidly throughout the cell. They distribute in a rather immobile pool located around the microtubule-organizing center in a cloud, and a highly dynamic pool in the cell periphery. Their spatiotemporal characteristics allow them to carry out multiple biological functions, such as cargo degradation, antigen presentation and plasma membrane repair. Therefore, it is not surprising that lysosomal dysfunction underlies various diseases, including cancer, neurodegenerative and autoimmune diseases. In most of these biological events, the involvement of lysosomes is dependent on their ability to move throughout the cytoplasm, to find and fuse to the correct compartments to receive and deliver substrates for further handling. These dynamics are orchestrated by motor proteins moving along cytoskeletal components. The complexity of the mechanisms responsible for controlling lysosomal transport has recently been appreciated and has yielded novel insights into interorganellar communication, as well as lipid-protein interplay. In this review, we discuss the current understanding of the mechanisms of lysosomal transport and the molecular machineries that control this mobility." @default.
- W2808041642 created "2018-06-21" @default.
- W2808041642 creator A5014742343 @default.
- W2808041642 creator A5060457244 @default.
- W2808041642 date "2018-07-17" @default.
- W2808041642 modified "2023-10-17" @default.
- W2808041642 title "Mechanisms of lysosomal positioning and movement" @default.
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