FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808045239> ?p ?o ?g. }

• W2808045239 abstract "Plasma microRNA (miR)‑423‑5p is a potential biomarker for the detection of colon cancer. However, the expression and biological role of miR‑423‑5p in colon tumorigenesis remains unclear. In the current study, reverse transcription‑quantitative polymerase chain reaction was used to determine miR‑423‑5p expression in malignant colon tissues and plasma from patients with colon cancer. Cell viability, colony formation and apoptosis assays, as well as western blotting, were performed to investigate the biological role and regulatory mechanisms of miR‑423‑5p in colon cancer. The results demonstrated that miR‑423‑5p expression was downregulated in tumor tissues and plasma from patients with colon cancer, as well as in colon cancer cell lines. Furthermore, overexpression of miR‑423‑5p promoted colon cancer cell apoptosis and resulted in the inhibition of cell proliferation and colony formation. Mechanistically, miR‑423‑5p induced the expression of caspases 3, 8 and 9, as well as p53 in colon cancer. The effect of z‑VAD treatment indicated that the miR‑423‑5p‑mediated colon cancer cell apoptosis is caspase‑dependent. These results suggest that miR‑423‑5p is a tumor suppressor in colon cancer and a potential diagnostic target to enable the early detection of colon cancer." @default.
• W2808045239 created "2018-06-21" @default.
• W2808045239 creator A5010705428 @default.
• W2808045239 creator A5012321817 @default.
• W2808045239 creator A5085961973 @default.
• W2808045239 creator A5088917578 @default.
• W2808045239 creator A5071559460 @default.
• W2808045239 date "2018-06-12" @default.
• W2808045239 modified "2023-09-22" @default.
• W2808045239 title "MicroRNA‑423‑5p inhibits colon cancer growth by promoting caspase‑dependent apoptosis" @default.
• W2808045239 cites W1752521503 @default.
• W2808045239 cites W175607371 @default.
• W2808045239 cites W1989891963 @default.
• W2808045239 cites W2015975359 @default.
• W2808045239 cites W2023945347 @default.
• W2808045239 cites W2031017817 @default.
• W2808045239 cites W2031830818 @default.
• W2808045239 cites W2039737850 @default.
• W2808045239 cites W2046718226 @default.
• W2808045239 cites W2052486422 @default.
• W2808045239 cites W2098055602 @default.
• W2808045239 cites W2098435003 @default.
• W2808045239 cites W2107277218 @default.
• W2808045239 cites W2114570899 @default.
• W2808045239 cites W2117692326 @default.
• W2808045239 cites W2125625976 @default.
• W2808045239 cites W2146894502 @default.
• W2808045239 cites W2159751663 @default.
• W2808045239 cites W2169727478 @default.
• W2808045239 cites W2174576345 @default.
• W2808045239 cites W2180388440 @default.
• W2808045239 cites W2192080449 @default.
• W2808045239 cites W2335964622 @default.
• W2808045239 cites W2465752596 @default.
• W2808045239 cites W2570618306 @default.
• W2808045239 cites W2604581858 @default.
• W2808045239 doi "https://doi.org/10.3892/etm.2018.6288" @default.
• W2808045239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6090304" @default.
• W2808045239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30116373" @default.
• W2808045239 hasPublicationYear "2018" @default.
• W2808045239 type Work @default.
• W2808045239 sameAs 2808045239 @default.
• W2808045239 citedByCount "17" @default.
• W2808045239 countsByYear W28080452392019 @default.
• W2808045239 countsByYear W28080452392020 @default.
• W2808045239 countsByYear W28080452392021 @default.
• W2808045239 countsByYear W28080452392022 @default.
• W2808045239 countsByYear W28080452392023 @default.
• W2808045239 crossrefType "journal-article" @default.
• W2808045239 hasAuthorship W2808045239A5010705428 @default.
• W2808045239 hasAuthorship W2808045239A5012321817 @default.
• W2808045239 hasAuthorship W2808045239A5071559460 @default.
• W2808045239 hasAuthorship W2808045239A5085961973 @default.
• W2808045239 hasAuthorship W2808045239A5088917578 @default.
• W2808045239 hasBestOaLocation W28080452391 @default.
• W2808045239 hasConcept C104317684 @default.
• W2808045239 hasConcept C121608353 @default.
• W2808045239 hasConcept C126322002 @default.
• W2808045239 hasConcept C145059251 @default.
• W2808045239 hasConcept C1491633281 @default.
• W2808045239 hasConcept C190283241 @default.
• W2808045239 hasConcept C2781018059 @default.
• W2808045239 hasConcept C29537977 @default.
• W2808045239 hasConcept C502942594 @default.
• W2808045239 hasConcept C526805850 @default.
• W2808045239 hasConcept C55493867 @default.
• W2808045239 hasConcept C555283112 @default.
• W2808045239 hasConcept C62112901 @default.
• W2808045239 hasConcept C67082663 @default.
• W2808045239 hasConcept C71924100 @default.
• W2808045239 hasConcept C85265743 @default.
• W2808045239 hasConcept C86803240 @default.
• W2808045239 hasConceptScore W2808045239C104317684 @default.
• W2808045239 hasConceptScore W2808045239C121608353 @default.
• W2808045239 hasConceptScore W2808045239C126322002 @default.
• W2808045239 hasConceptScore W2808045239C145059251 @default.
• W2808045239 hasConceptScore W2808045239C1491633281 @default.
• W2808045239 hasConceptScore W2808045239C190283241 @default.
• W2808045239 hasConceptScore W2808045239C2781018059 @default.
• W2808045239 hasConceptScore W2808045239C29537977 @default.
• W2808045239 hasConceptScore W2808045239C502942594 @default.
• W2808045239 hasConceptScore W2808045239C526805850 @default.
• W2808045239 hasConceptScore W2808045239C55493867 @default.
• W2808045239 hasConceptScore W2808045239C555283112 @default.
• W2808045239 hasConceptScore W2808045239C62112901 @default.
• W2808045239 hasConceptScore W2808045239C67082663 @default.
• W2808045239 hasConceptScore W2808045239C71924100 @default.
• W2808045239 hasConceptScore W2808045239C85265743 @default.
• W2808045239 hasConceptScore W2808045239C86803240 @default.
• W2808045239 hasLocation W28080452391 @default.
• W2808045239 hasLocation W28080452392 @default.
• W2808045239 hasLocation W28080452393 @default.
• W2808045239 hasLocation W28080452394 @default.
• W2808045239 hasOpenAccess W2808045239 @default.
• W2808045239 hasPrimaryLocation W28080452391 @default.
• W2808045239 hasRelatedWork W2159406762 @default.
• W2808045239 hasRelatedWork W2348417465 @default.
• W2808045239 hasRelatedWork W2529723636 @default.
• W2808045239 hasRelatedWork W2769260613 @default.
• W2808045239 hasRelatedWork W2772993264 @default.

• next