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• W2808045511 abstract "ABSTRACT MicroRNAs (miRNAs) are endogenous small non-coding RNAs that negatively regulate gene expression by targeting specific mRNAs; they are involved in the modulation of important mRNA networks involved in toxicity. Atrazine is a known endocrine-disrupting chemical, whose molecular mechanisms are unknown. In this study, common carp ( Cyprinus carpio ) gonads at two key developmental stages were exposed to 0.428 ppb atrazine for 24 h in vitro . MiRNA expression profiles were analysed to identify miRNAs related to gonad development and to reveal the atrazine mechanisms interfering with gonad differentiation. Atrazine exposure caused significant alteration of multiple miRNAs. Compared with the juvenile ovary, more miRNAs were down-regulated in juvenile testis, some of these down-regulated miRNAs target the steroid hormone biosynthesis pathway related-genes. Predicted target genes of differently-expressed miRNAs after exposure to atrazine were involved in many reproductive biology signalling pathways. We suggest that these target genes may have important roles in atrazine-induced reproductive toxicity by altering miRNAs expression. Our results also indicate that atrazine can up-regulate aromatase expression through miRNAs, which supports the hypothesis that atrazine has endocrine-disrupting activity by altering the expression of genes of the Hypothalamus-Pituitary-Gonad axis through its corresponding miRNAs. This study tells us the following conclusions: 1. Atrazine exposure results in significant alterations of miRNAs whose predicted target genes are associated with reproductive processes. 2. In the primordial gonad, atrazine promoted the expression of early gonad-determining genes by decreasing specific miRNAs. 3. In the juvenile gonad, atrazine promoted the biosynthesis of steroid hormones." @default.
• W2808045511 created "2018-06-21" @default.
• W2808045511 creator A5002661071 @default.
• W2808045511 creator A5025067580 @default.
• W2808045511 creator A5027647185 @default.
• W2808045511 creator A5051166329 @default.
• W2808045511 creator A5065032385 @default.
• W2808045511 date "2018-06-12" @default.
• W2808045511 modified "2023-09-28" @default.
• W2808045511 title "Effects of Short-time Exposure to Atrazine on miRNA Expression Profiles in the Gonad of Common Carp (Cyprinus carpio)" @default.
• W2808045511 cites W144423133 @default.
• W2808045511 cites W1958284284 @default.
• W2808045511 cites W1975304818 @default.
• W2808045511 cites W1977063410 @default.
• W2808045511 cites W1977712961 @default.
• W2808045511 cites W1978526370 @default.
• W2808045511 cites W1979667801 @default.
• W2808045511 cites W1981642231 @default.
• W2808045511 cites W1981976677 @default.
• W2808045511 cites W1987065797 @default.
• W2808045511 cites W1990105332 @default.
• W2808045511 cites W1995613914 @default.
• W2808045511 cites W2001309523 @default.
• W2808045511 cites W2003419304 @default.
• W2808045511 cites W2005695503 @default.
• W2808045511 cites W2006169630 @default.
• W2808045511 cites W2008289103 @default.
• W2808045511 cites W2015229715 @default.
• W2808045511 cites W2015750766 @default.
• W2808045511 cites W2016255533 @default.
• W2808045511 cites W2018784772 @default.
• W2808045511 cites W2023606507 @default.
• W2808045511 cites W2023704290 @default.
• W2808045511 cites W2027862889 @default.
• W2808045511 cites W2030166934 @default.
• W2808045511 cites W2030406469 @default.
• W2808045511 cites W2032978676 @default.
• W2808045511 cites W2034793355 @default.
• W2808045511 cites W2046014802 @default.
• W2808045511 cites W2046930479 @default.
• W2808045511 cites W2049868101 @default.
• W2808045511 cites W2056449588 @default.
• W2808045511 cites W2059357290 @default.
• W2808045511 cites W2061024105 @default.
• W2808045511 cites W2062148168 @default.
• W2808045511 cites W2065456229 @default.
• W2808045511 cites W2065932646 @default.
• W2808045511 cites W2066992828 @default.
• W2808045511 cites W2069644908 @default.
• W2808045511 cites W2070521419 @default.
• W2808045511 cites W2070908085 @default.
• W2808045511 cites W2071925802 @default.
• W2808045511 cites W2073417234 @default.
• W2808045511 cites W2081150348 @default.
• W2808045511 cites W2082041132 @default.
• W2808045511 cites W2083607762 @default.
• W2808045511 cites W2084486673 @default.
• W2808045511 cites W2084675240 @default.
• W2808045511 cites W2087799143 @default.
• W2808045511 cites W2089499735 @default.
• W2808045511 cites W2096819533 @default.
• W2808045511 cites W2098856495 @default.
• W2808045511 cites W2106666165 @default.
• W2808045511 cites W2110525565 @default.
• W2808045511 cites W2111469134 @default.
• W2808045511 cites W2117391818 @default.
• W2808045511 cites W2117925584 @default.
• W2808045511 cites W2120373392 @default.
• W2808045511 cites W2123060905 @default.
• W2808045511 cites W2123430113 @default.
• W2808045511 cites W2124296011 @default.
• W2808045511 cites W2125471482 @default.
• W2808045511 cites W2125489084 @default.
• W2808045511 cites W2126277206 @default.
• W2808045511 cites W2131427796 @default.
• W2808045511 cites W2137257434 @default.
• W2808045511 cites W2138433638 @default.
• W2808045511 cites W2139863005 @default.
• W2808045511 cites W2140429790 @default.
• W2808045511 cites W2141209999 @default.
• W2808045511 cites W2142156434 @default.
• W2808045511 cites W2142826255 @default.
• W2808045511 cites W2144093986 @default.
• W2808045511 cites W2146516445 @default.
• W2808045511 cites W2153628066 @default.
• W2808045511 cites W2155620039 @default.
• W2808045511 cites W2157193551 @default.
• W2808045511 cites W2157428610 @default.
• W2808045511 cites W2162674813 @default.
• W2808045511 cites W2163729283 @default.
• W2808045511 cites W2165139205 @default.
• W2808045511 cites W2166542953 @default.
• W2808045511 cites W2167387657 @default.
• W2808045511 cites W2175886889 @default.
• W2808045511 cites W2258569606 @default.
• W2808045511 cites W2262873841 @default.
• W2808045511 cites W2297876825 @default.
• W2808045511 cites W2318546493 @default.
• W2808045511 cites W2419393276 @default.
• W2808045511 cites W2472861973 @default.

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