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• W2808045882 abstract "ObjectivesData on the management and outcomes of Staphylococcus aureus bacteraemia (SAB) in resource-limited settings are limited. The aim of this study was to describe a cohort of South African patients with SAB, and explore the factors associated with complicated infection and death.MethodsThis was a prospective observational study of patients over the age of 13 years admitted to a South African referral hospital with SAB.ResultsOne hundred SAB infection episodes occurring in 98 patients were included. SAB was healthcare-associated in 68.4%; 24.0% of all cases were caused by methicillin-resistant S. aureus (MRSA). Ninety-day mortality was 47.0%, with 83.3% of deaths attributable to SAB. There was a trend towards increased 90-day mortality with MRSA infection (odds ratio (OR) 1.28, 95% confidence interval (CI) 1.0–15.1) and the presence of comorbidities (OR 4.1, 95% CI 1.0–21.6). The risk of complicated infection was higher with non-optimal definitive antibiotic therapy (OR 8.5, 95% CI 1.8–52.4), female sex (OR 3.8, 95% CI 1.1–16.3), and community-acquired infection (OR 7.4, 95% CI 2.0–33.1). Definitive antibiotic therapy was non-optimal in 22.6% of all cases.ConclusionsSAB-related mortality was high. A large proportion of cases may be preventable, and there is a need for improved antibiotic management." @default.
• W2808045882 created "2018-06-21" @default.
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• W2808045882 date "2018-08-01" @default.
• W2808045882 modified "2023-10-07" @default.
• W2808045882 title "The management and outcomes of Staphylococcus aureus bacteraemia at a South African referral hospital: A prospective observational study" @default.
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• W2808045882 doi "https://doi.org/10.1016/j.ijid.2018.06.004" @default.
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