FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808050319> ?p ?o ?g. }

• W2808050319 endingPage "93" @default.
• W2808050319 startingPage "82" @default.
• W2808050319 abstract "We aimed to investigate the beneficial effect of Celastrol on inner ear stem cells and potential therapeutic value for hearing loss. The inner ear stem cells were isolated and characterized from utricular sensory epithelium of adult mice. The stemness was evaluated by sphere formation assay. The relative expressions of Atoh1, MAP-2 and Myosin VI were measured by RT-PCR and immunoblotting. The up-regulation of MAP-2 was also analysed with immunofluorescence. The in vitro neuronal excitability was interrogated by calcium oscillation. The electrophysiological property was determined by inward current recorded on patch clamp. Our results demonstrated that Celastrol treatment significantly improved the viability and proliferation of mouse inner ear stem cells, and facilitated sphere formation. Moreover, Celastrol stimulated differentiation of mouse inner ear stem cells to neuronal-like cells and enhanced neural excitability. Celastrol also enhanced neuronal-like cell identity in the inner ear stem cell derived neurons, as well as their electrophysiological function. Most notably, these effects were apparently associated with the upregulation of Atoh1 in response to Celastrol treatment. Celastrol showed beneficial effect on inner ear stem cells and held therapeutic promise against hearing loss." @default.
• W2808050319 created "2018-06-21" @default.
• W2808050319 creator A5060895963 @default.
• W2808050319 creator A5063499861 @default.
• W2808050319 creator A5071734108 @default.
• W2808050319 creator A5084685237 @default.
• W2808050319 creator A5090448088 @default.
• W2808050319 date "2018-04-03" @default.
• W2808050319 modified "2023-10-17" @default.
• W2808050319 title "Celastrol enhances Atoh1 expression in inner ear stem cells and promotes their differentiation into functional auditory neuronal-like cells" @default.
• W2808050319 cites W1567266181 @default.
• W2808050319 cites W1629045112 @default.
• W2808050319 cites W1664617222 @default.
• W2808050319 cites W1990400728 @default.
• W2808050319 cites W1995048201 @default.
• W2808050319 cites W2011131922 @default.
• W2808050319 cites W2012694604 @default.
• W2808050319 cites W2014267924 @default.
• W2808050319 cites W2014311428 @default.
• W2808050319 cites W2017453705 @default.
• W2808050319 cites W2018514799 @default.
• W2808050319 cites W2021103630 @default.
• W2808050319 cites W2027844138 @default.
• W2808050319 cites W2028912825 @default.
• W2808050319 cites W2029000342 @default.
• W2808050319 cites W2035189713 @default.
• W2808050319 cites W2049903984 @default.
• W2808050319 cites W2051328153 @default.
• W2808050319 cites W2062868705 @default.
• W2808050319 cites W2063492497 @default.
• W2808050319 cites W2093640897 @default.
• W2808050319 cites W2105493567 @default.
• W2808050319 cites W2132842784 @default.
• W2808050319 cites W2167757351 @default.
• W2808050319 cites W2168999576 @default.
• W2808050319 cites W2191674642 @default.
• W2808050319 cites W2514096019 @default.
• W2808050319 cites W33964925 @default.
• W2808050319 doi "https://doi.org/10.1080/15476278.2018.1462433" @default.
• W2808050319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6150060" @default.
• W2808050319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29902110" @default.
• W2808050319 hasPublicationYear "2018" @default.
• W2808050319 type Work @default.
• W2808050319 sameAs 2808050319 @default.
• W2808050319 citedByCount "6" @default.
• W2808050319 countsByYear W28080503192019 @default.
• W2808050319 countsByYear W28080503192020 @default.
• W2808050319 countsByYear W28080503192022 @default.
• W2808050319 countsByYear W28080503192023 @default.
• W2808050319 crossrefType "journal-article" @default.
• W2808050319 hasAuthorship W2808050319A5060895963 @default.
• W2808050319 hasAuthorship W2808050319A5063499861 @default.
• W2808050319 hasAuthorship W2808050319A5071734108 @default.
• W2808050319 hasAuthorship W2808050319A5084685237 @default.
• W2808050319 hasAuthorship W2808050319A5090448088 @default.
• W2808050319 hasBestOaLocation W28080503191 @default.
• W2808050319 hasConcept C104317684 @default.
• W2808050319 hasConcept C147944092 @default.
• W2808050319 hasConcept C148738053 @default.
• W2808050319 hasConcept C169760540 @default.
• W2808050319 hasConcept C185263204 @default.
• W2808050319 hasConcept C185592680 @default.
• W2808050319 hasConcept C190283241 @default.
• W2808050319 hasConcept C2777228702 @default.
• W2808050319 hasConcept C2778500370 @default.
• W2808050319 hasConcept C28328180 @default.
• W2808050319 hasConcept C55493867 @default.
• W2808050319 hasConcept C86803240 @default.
• W2808050319 hasConcept C95444343 @default.
• W2808050319 hasConceptScore W2808050319C104317684 @default.
• W2808050319 hasConceptScore W2808050319C147944092 @default.
• W2808050319 hasConceptScore W2808050319C148738053 @default.
• W2808050319 hasConceptScore W2808050319C169760540 @default.
• W2808050319 hasConceptScore W2808050319C185263204 @default.
• W2808050319 hasConceptScore W2808050319C185592680 @default.
• W2808050319 hasConceptScore W2808050319C190283241 @default.
• W2808050319 hasConceptScore W2808050319C2777228702 @default.
• W2808050319 hasConceptScore W2808050319C2778500370 @default.
• W2808050319 hasConceptScore W2808050319C28328180 @default.
• W2808050319 hasConceptScore W2808050319C55493867 @default.
• W2808050319 hasConceptScore W2808050319C86803240 @default.
• W2808050319 hasConceptScore W2808050319C95444343 @default.
• W2808050319 hasFunder F4320321001 @default.
• W2808050319 hasIssue "2" @default.
• W2808050319 hasLocation W28080503191 @default.
• W2808050319 hasLocation W28080503192 @default.
• W2808050319 hasLocation W28080503193 @default.
• W2808050319 hasOpenAccess W2808050319 @default.
• W2808050319 hasPrimaryLocation W28080503191 @default.
• W2808050319 hasRelatedWork W159517055 @default.
• W2808050319 hasRelatedWork W2009519731 @default.
• W2808050319 hasRelatedWork W2072757479 @default.
• W2808050319 hasRelatedWork W2300366807 @default.
• W2808050319 hasRelatedWork W2382150452 @default.
• W2808050319 hasRelatedWork W2701711015 @default.
• W2808050319 hasRelatedWork W3110597556 @default.
• W2808050319 hasRelatedWork W3120507315 @default.
• W2808050319 hasRelatedWork W4205583335 @default.

• next