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- W28080516 abstract "A group of bacterial and viral proteins termed superantigens share the ability to associate with T cell receptor (TCR) and major histocompatibility complex (MHC) class II molecules, generating unique multimeric protein complexes that trigger polyclonal T cell activation [1–4]. Members of the superantigen family include bacterial exotoxins like staphylococcal enterotoxins and toxic shock syndrome toxin-1 (TSST-1), proteins encoded by viral genomes, and retroviral products from mouse mammary tumor viruses [1, 5, 6]. The mechanisms by which superantigens stimulate T cells differ from those of conventional antigens, which require endocytosis and proteolytic processing for presentation of MHC-bound antigenic peptides to T lymphocytes. In contrast, superantigens interact with MHC class II molecules as intact proteins at a site distinct from the peptide binding groove without conformational changes of MHC proteins or superantigens occurring upon complex formation (Fig. 1) [7–13]. The superantigen binding region of MHC class II proteins seems to be conserved among different mammalian haplotypes since superantigens bind to murine, rat, and human class II molecules [3, 14]." @default.
- W28080516 created "2016-06-24" @default.
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- W28080516 date "1999-01-01" @default.
- W28080516 modified "2023-09-26" @default.
- W28080516 title "Acute lung inflammation in septic shock of the cytokine release induced by bacterial superantigens" @default.
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- W28080516 doi "https://doi.org/10.1007/978-3-0348-8755-7_2" @default.
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