Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808057431> ?p ?o ?g. }
- W2808057431 endingPage "780" @default.
- W2808057431 startingPage "767" @default.
- W2808057431 abstract "Metabolic profiling was used to discover mechanisms of increased pneumocandin B0 production in a high-yield strain by comparing it with its parent strain. Initially, 79 intracellular metabolites were identified, and the levels of 15 metabolites involved in six pathways were found to be directly correlated with pneumocandin B0 biosynthesis. Then by combining the analysis of key enzymes, acetyl-CoA and NADPH were identified as the main factors limiting pneumocandin B0 biosynthesis. Other metabolites, such as pyruvate, α-ketoglutaric acid, lactate, unsaturated fatty acids and previously unreported metabolite γ-aminobutyric acid were shown to play important roles in pneumocandin B0 biosynthesis and cell growth. Finally, the overall metabolic mechanism hypothesis was formulated and a rational feeding strategy was implemented that increased the pneumocandin B0 yield from 1821 to 2768 mg/L. These results provide practical and theoretical guidance for strain selection, medium optimization, and genetic engineering for pneumocandin B0 production." @default.
- W2808057431 created "2018-06-21" @default.
- W2808057431 creator A5026954484 @default.
- W2808057431 creator A5030064573 @default.
- W2808057431 creator A5038760380 @default.
- W2808057431 creator A5048769114 @default.
- W2808057431 creator A5049209739 @default.
- W2808057431 creator A5060114713 @default.
- W2808057431 creator A5067534896 @default.
- W2808057431 creator A5075064641 @default.
- W2808057431 creator A5088890150 @default.
- W2808057431 date "2018-09-01" @default.
- W2808057431 modified "2023-10-17" @default.
- W2808057431 title "Metabolomics profiling reveals the mechanism of increased pneumocandin B0 production by comparing mutant and parent strains" @default.
- W2808057431 cites W125418073 @default.
- W2808057431 cites W1588314853 @default.
- W2808057431 cites W1735081142 @default.
- W2808057431 cites W1831110184 @default.
- W2808057431 cites W1931469959 @default.
- W2808057431 cites W1964064737 @default.
- W2808057431 cites W1968599622 @default.
- W2808057431 cites W1974307143 @default.
- W2808057431 cites W1974916009 @default.
- W2808057431 cites W1975638761 @default.
- W2808057431 cites W1984885867 @default.
- W2808057431 cites W1990105826 @default.
- W2808057431 cites W1992190679 @default.
- W2808057431 cites W1998777096 @default.
- W2808057431 cites W2011966585 @default.
- W2808057431 cites W2051821524 @default.
- W2808057431 cites W2051953123 @default.
- W2808057431 cites W2054617539 @default.
- W2808057431 cites W2073757763 @default.
- W2808057431 cites W2075967007 @default.
- W2808057431 cites W2079203780 @default.
- W2808057431 cites W2081306218 @default.
- W2808057431 cites W2085095150 @default.
- W2808057431 cites W2093628012 @default.
- W2808057431 cites W2098898162 @default.
- W2808057431 cites W2099951777 @default.
- W2808057431 cites W2124859343 @default.
- W2808057431 cites W2128635872 @default.
- W2808057431 cites W2129123789 @default.
- W2808057431 cites W2142376954 @default.
- W2808057431 cites W2159541908 @default.
- W2808057431 cites W2165081621 @default.
- W2808057431 cites W2167700458 @default.
- W2808057431 cites W2202219285 @default.
- W2808057431 cites W2221539017 @default.
- W2808057431 cites W2330333663 @default.
- W2808057431 cites W2331432610 @default.
- W2808057431 cites W2331818893 @default.
- W2808057431 cites W2483035198 @default.
- W2808057431 cites W2524679174 @default.
- W2808057431 cites W2572728229 @default.
- W2808057431 cites W2761108102 @default.
- W2808057431 cites W4243159522 @default.
- W2808057431 cites W4293247451 @default.
- W2808057431 doi "https://doi.org/10.1007/s10295-018-2047-z" @default.
- W2808057431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29948195" @default.
- W2808057431 hasPublicationYear "2018" @default.
- W2808057431 type Work @default.
- W2808057431 sameAs 2808057431 @default.
- W2808057431 citedByCount "10" @default.
- W2808057431 countsByYear W28080574312018 @default.
- W2808057431 countsByYear W28080574312019 @default.
- W2808057431 countsByYear W28080574312020 @default.
- W2808057431 countsByYear W28080574312021 @default.
- W2808057431 countsByYear W28080574312023 @default.
- W2808057431 crossrefType "journal-article" @default.
- W2808057431 hasAuthorship W2808057431A5026954484 @default.
- W2808057431 hasAuthorship W2808057431A5030064573 @default.
- W2808057431 hasAuthorship W2808057431A5038760380 @default.
- W2808057431 hasAuthorship W2808057431A5048769114 @default.
- W2808057431 hasAuthorship W2808057431A5049209739 @default.
- W2808057431 hasAuthorship W2808057431A5060114713 @default.
- W2808057431 hasAuthorship W2808057431A5067534896 @default.
- W2808057431 hasAuthorship W2808057431A5075064641 @default.
- W2808057431 hasAuthorship W2808057431A5088890150 @default.
- W2808057431 hasConcept C104317684 @default.
- W2808057431 hasConcept C127413603 @default.
- W2808057431 hasConcept C135870905 @default.
- W2808057431 hasConcept C143065580 @default.
- W2808057431 hasConcept C181199279 @default.
- W2808057431 hasConcept C185592680 @default.
- W2808057431 hasConcept C188198153 @default.
- W2808057431 hasConcept C192989942 @default.
- W2808057431 hasConcept C21565614 @default.
- W2808057431 hasConcept C2777477808 @default.
- W2808057431 hasConcept C553450214 @default.
- W2808057431 hasConcept C55493867 @default.
- W2808057431 hasConcept C60644358 @default.
- W2808057431 hasConcept C6350086 @default.
- W2808057431 hasConcept C78519656 @default.
- W2808057431 hasConcept C86803240 @default.
- W2808057431 hasConceptScore W2808057431C104317684 @default.
- W2808057431 hasConceptScore W2808057431C127413603 @default.
- W2808057431 hasConceptScore W2808057431C135870905 @default.