Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808060897> ?p ?o ?g. }
- W2808060897 endingPage "179" @default.
- W2808060897 startingPage "174" @default.
- W2808060897 abstract "An efficient chemoenzymatic route was developed for synthesis of (S)-α-amino-4-fluorobenzeneacetic acid, a valuable chiral intermediate of Aprepitant, using immobilized penicillin amidase catalyzed kinetic resolution of racemic N-phenylacetyl-4-fluorophenylglycine. The optimum temperature, pH and agitation rate of the reaction were determined to be 40 °C, 9.5 and 300 rpm, respectively. Kinetic resolution of 80 g L−1 N-phenylacetyl-4-fluorophenylglycine by immobilized amidase 20 g L−1 resulted in 49.9% conversion and >99.9% e.e. within 3 h. The unreacted N-phenylacetyl-4-fluorophenylglycine can be easily racemized and then recycled as substrate. The production of (S)-α-amino-4-fluorobenzeneacetic acid was further amplified in 1 L reaction system, affording excellent conversion (49.9%) and enantioselectivity (99.9%). This chemoenzymatic approach was demonstrated to be promising for industrial production of (S)-α-amino-4-fluorobenzeneacetic acid." @default.
- W2808060897 created "2018-06-21" @default.
- W2808060897 creator A5000295665 @default.
- W2808060897 creator A5018886259 @default.
- W2808060897 creator A5054986036 @default.
- W2808060897 creator A5070021680 @default.
- W2808060897 date "2018-10-01" @default.
- W2808060897 modified "2023-09-26" @default.
- W2808060897 title "Efficient chemoenzymatic synthesis of (S)-α-amino-4-fluorobenzeneacetic acid using immobilized penicillin amidase" @default.
- W2808060897 cites W1974229163 @default.
- W2808060897 cites W1985551983 @default.
- W2808060897 cites W2002189742 @default.
- W2808060897 cites W2012484138 @default.
- W2808060897 cites W2021988071 @default.
- W2808060897 cites W2023324834 @default.
- W2808060897 cites W2037198330 @default.
- W2808060897 cites W2043729296 @default.
- W2808060897 cites W2043862101 @default.
- W2808060897 cites W2067625844 @default.
- W2808060897 cites W2089553725 @default.
- W2808060897 cites W2094228596 @default.
- W2808060897 cites W2100556200 @default.
- W2808060897 cites W2116613381 @default.
- W2808060897 cites W2136466333 @default.
- W2808060897 cites W2170349211 @default.
- W2808060897 cites W2265083603 @default.
- W2808060897 cites W2295000077 @default.
- W2808060897 cites W2314546505 @default.
- W2808060897 cites W2343990882 @default.
- W2808060897 cites W2751743037 @default.
- W2808060897 cites W2793388895 @default.
- W2808060897 cites W2949554707 @default.
- W2808060897 cites W2950993589 @default.
- W2808060897 doi "https://doi.org/10.1016/j.bioorg.2018.06.020" @default.
- W2808060897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29929078" @default.
- W2808060897 hasPublicationYear "2018" @default.
- W2808060897 type Work @default.
- W2808060897 sameAs 2808060897 @default.
- W2808060897 citedByCount "9" @default.
- W2808060897 countsByYear W28080608972019 @default.
- W2808060897 countsByYear W28080608972020 @default.
- W2808060897 countsByYear W28080608972021 @default.
- W2808060897 crossrefType "journal-article" @default.
- W2808060897 hasAuthorship W2808060897A5000295665 @default.
- W2808060897 hasAuthorship W2808060897A5018886259 @default.
- W2808060897 hasAuthorship W2808060897A5054986036 @default.
- W2808060897 hasAuthorship W2808060897A5070021680 @default.
- W2808060897 hasConcept C111368507 @default.
- W2808060897 hasConcept C127313418 @default.
- W2808060897 hasConcept C146686406 @default.
- W2808060897 hasConcept C161790260 @default.
- W2808060897 hasConcept C174802600 @default.
- W2808060897 hasConcept C178790620 @default.
- W2808060897 hasConcept C181199279 @default.
- W2808060897 hasConcept C185592680 @default.
- W2808060897 hasConcept C21951064 @default.
- W2808060897 hasConcept C2777289219 @default.
- W2808060897 hasConcept C2777451570 @default.
- W2808060897 hasConcept C28173026 @default.
- W2808060897 hasConcept C33633552 @default.
- W2808060897 hasConcept C43617362 @default.
- W2808060897 hasConcept C501593827 @default.
- W2808060897 hasConcept C515207424 @default.
- W2808060897 hasConcept C55493867 @default.
- W2808060897 hasConcept C65588867 @default.
- W2808060897 hasConcept C71240020 @default.
- W2808060897 hasConceptScore W2808060897C111368507 @default.
- W2808060897 hasConceptScore W2808060897C127313418 @default.
- W2808060897 hasConceptScore W2808060897C146686406 @default.
- W2808060897 hasConceptScore W2808060897C161790260 @default.
- W2808060897 hasConceptScore W2808060897C174802600 @default.
- W2808060897 hasConceptScore W2808060897C178790620 @default.
- W2808060897 hasConceptScore W2808060897C181199279 @default.
- W2808060897 hasConceptScore W2808060897C185592680 @default.
- W2808060897 hasConceptScore W2808060897C21951064 @default.
- W2808060897 hasConceptScore W2808060897C2777289219 @default.
- W2808060897 hasConceptScore W2808060897C2777451570 @default.
- W2808060897 hasConceptScore W2808060897C28173026 @default.
- W2808060897 hasConceptScore W2808060897C33633552 @default.
- W2808060897 hasConceptScore W2808060897C43617362 @default.
- W2808060897 hasConceptScore W2808060897C501593827 @default.
- W2808060897 hasConceptScore W2808060897C515207424 @default.
- W2808060897 hasConceptScore W2808060897C55493867 @default.
- W2808060897 hasConceptScore W2808060897C65588867 @default.
- W2808060897 hasConceptScore W2808060897C71240020 @default.
- W2808060897 hasLocation W28080608971 @default.
- W2808060897 hasLocation W28080608972 @default.
- W2808060897 hasOpenAccess W2808060897 @default.
- W2808060897 hasPrimaryLocation W28080608971 @default.
- W2808060897 hasRelatedWork W2002618074 @default.
- W2808060897 hasRelatedWork W2094387936 @default.
- W2808060897 hasRelatedWork W2119101293 @default.
- W2808060897 hasRelatedWork W2295000077 @default.
- W2808060897 hasRelatedWork W2332429907 @default.
- W2808060897 hasRelatedWork W2379182415 @default.
- W2808060897 hasRelatedWork W2951350801 @default.
- W2808060897 hasRelatedWork W2951443849 @default.
- W2808060897 hasRelatedWork W2952944682 @default.