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- W2808064086 abstract "Enzymes are versatile catalysts for ex situ and in situ synthesis of wound dressing hydrogels (WDHs). Enzymes in WDH prevent microbial infection and colonization of the wound. Enzymes as bioactive molecules in WDHs promote wound healing. Enzymes can serve as in situ microbial infection and diagnostic systems in WDHs. Hydrogels are 3D hydrophilic polymer networks that absorb and hold huge amounts of water. Although hydrogels have traditionally been synthesized using chemical and physical methods, rapid developments in enzyme technology that, like chemical-based methods, enable the formation of stable covalent bonds are fast emerging as alternative ‘green catalyst’ tools. Enzymes show great potential for the synthesis of complex multifunctional wound dressing hydrogels (WDHs) ex situ and in situ as well as in acting as interactive molecules to promote the wound healing process. This review presents advances in the use of enzymes to synthesize WDHs and their fascinating role as bioactive molecules promoting the wound healing process, preventing microbial infection, and providing in situ, in-built infection-detection and diagnostic systems. Hydrogels are 3D hydrophilic polymer networks that absorb and hold huge amounts of water. Although hydrogels have traditionally been synthesized using chemical and physical methods, rapid developments in enzyme technology that, like chemical-based methods, enable the formation of stable covalent bonds are fast emerging as alternative ‘green catalyst’ tools. Enzymes show great potential for the synthesis of complex multifunctional wound dressing hydrogels (WDHs) ex situ and in situ as well as in acting as interactive molecules to promote the wound healing process. This review presents advances in the use of enzymes to synthesize WDHs and their fascinating role as bioactive molecules promoting the wound healing process, preventing microbial infection, and providing in situ, in-built infection-detection and diagnostic systems. generally, compounds that exert an effect on a living organism or their parts (cells, tissues, or organs). chemoattractant cytokines involved in cell migration that play key roles throughout the wound healing process, especially during the inflammatory and proliferative phases. a molecule that can be converted into a colored compound or dye. a wound that fails to proceed through the normal phases of the wound healing process in an orderly and timely manner, often remaining in the inflammation phase. cell-signaling molecules that help cell-to-cell communication in immune responses and stimulate the movement of cells towards sites of infection or trauma. implicated in keratinocyte migration, fibroblast proliferation and differentiation, and granulation tissue formation. a complex network of many different macromolecules (proteoglycans, collagens, fibronectin, elastin, glycosaminoglycans, glycoproteins, heparin, etc.) that regulates many important cell functions such as cell proliferation, migration, apoptosis, differentiation, and adhesion, including during the wound healing process. a large family of mitogens that are actively involved in the processes of wound healing, embryonic development, and angiogenesis. a molecule that fluoresces. hormone-like polypeptide molecules that control the growth, differentiation, and metabolism of cells by interacting specifically with cell-surface receptors to control tissue repair. accelerates epidermal wound healing and inhibits apoptosis pathways. conditions under which tissues do not receive sufficient oxygen important for cellular respiration. mediator of epithelial cell growth. a water-soluble polysaccharide component of hemicellulose found in an Asian plant, Amorphophallus konjac, that is used to make highly viscous konjac jelly. It has many putative health benefits in traditional Chinese medicine. a large family of proteases that regulate extracellular matrix degradation and deposition essential for wound healing. involved in promoting all stages of wound healing. wounds that may involve tissue loss at the epidermis and dermis levels (e.g., abrasion injuries, most blisters). stimulates cell differentiation, proliferation, apoptosis, and matrix production. stimulates neovascularization, re-epithelialization, and endothelial cell proliferation and migration. a process that removes necrotic tissue forming on the wound that prevents effective healing of the wound." @default.
- W2808064086 created "2018-06-21" @default.
- W2808064086 creator A5031459554 @default.
- W2808064086 creator A5071790968 @default.
- W2808064086 date "2018-10-01" @default.
- W2808064086 modified "2023-10-16" @default.
- W2808064086 title "Enzymes as Green Catalysts and Interactive Biomolecules in Wound Dressing Hydrogels" @default.
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- W2808064086 doi "https://doi.org/10.1016/j.tibtech.2018.05.006" @default.
- W2808064086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29914650" @default.
- W2808064086 hasPublicationYear "2018" @default.
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