FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808068978> ?p ?o ?g. }

• W2808068978 endingPage "e1002589" @default.
• W2808068978 startingPage "e1002589" @default.
• W2808068978 abstract "Background Systematic reviews have described high rates of attrition in patients with HIV receiving antiretroviral therapy (ART). However, migration and clinical transfer may lead to an overestimation of attrition (death and loss to follow-up). Using a newly linked national laboratory database in South Africa, we assessed national retention in South Africa’s national HIV program. Methods and findings Patients receiving care in South Africa’s national HIV program are monitored through regular CD4 count and viral load testing. South Africa’s National Health Laboratory Service has maintained a database of all public-sector CD4 count and viral load results since 2004. We linked individual laboratory results to patients using probabilistic matching techniques, creating a national HIV cohort. Validation of our approach in comparison to a manually matched dataset showed 9.0% undermatching and 9.5% overmatching. We analyzed data on patients initiating ART in the public sector from April 1, 2004, to December 31, 2006, when ART initiation could be determined based on first viral load among those whose treatment followed guidelines. Attrition occurred on the date of a patient’s last observed laboratory measure, allowing patients to exit and reenter care prior to that date. All patients had 6 potential years of follow-up, with an additional 2 years to have a final laboratory measurement to be retained at 6 years. Data were censored at December 31, 2012. We assessed (a) national retention including all laboratory tests regardless of testing facility and (b) initiating facility retention, where laboratory tests at other facilities were ignored. We followed 55,836 patients initiating ART between 2004 and 2006. At ART initiation, median age was 36 years (IQR: 30–43), median CD4 count was 150 cells/mm3 (IQR: 81–230), and 66.7% were female. Six-year initiating clinic retention was 29.1% (95% CI: 28.7%–29.5%). After allowing for transfers, national 6-year retention was 63.3% (95% CI: 62.9%–63.7%). Results differed little when tightening or relaxing matching procedures. We found strong differences in retention by province, ranging from 74.2% (95% CI: 73.2%–75.2%) in Western Cape to 52.2% (95% CI: 50.6%–53.7%) in Mpumalanga at 6 years. National attrition was higher among patients initiating at lower CD4 counts and higher viral loads, and among patients initiating ART at larger facilities. The study’s main limitation is lack of perfect cohort matching, which may lead to over- or underestimation of retention. We also did not have data from KwaZulu-Natal province prior to 2010. Conclusions In this study, HIV care retention was substantially higher when viewed from a national perspective than from a facility perspective. Our results suggest that traditional clinical cohorts underestimate retention." @default.
• W2808068978 created "2018-06-21" @default.
• W2808068978 creator A5010315274 @default.
• W2808068978 creator A5039166958 @default.
• W2808068978 creator A5044667291 @default.
• W2808068978 creator A5050583060 @default.
• W2808068978 creator A5051155900 @default.
• W2808068978 creator A5061720638 @default.
• W2808068978 creator A5074213191 @default.
• W2808068978 date "2018-06-11" @default.
• W2808068978 modified "2023-10-11" @default.
• W2808068978 title "Estimating retention in HIV care accounting for patient transfers: A national laboratory cohort study in South Africa" @default.
• W2808068978 cites W1971077001 @default.
• W2808068978 cites W1977510678 @default.
• W2808068978 cites W2001549763 @default.
• W2808068978 cites W2026205758 @default.
• W2808068978 cites W2026215038 @default.
• W2808068978 cites W2033853316 @default.
• W2808068978 cites W2036408211 @default.
• W2808068978 cites W2051727386 @default.
• W2808068978 cites W2052723502 @default.
• W2808068978 cites W2055868383 @default.
• W2808068978 cites W2056440737 @default.
• W2808068978 cites W2066534928 @default.
• W2808068978 cites W2068976984 @default.
• W2808068978 cites W2073471108 @default.
• W2808068978 cites W2076187843 @default.
• W2808068978 cites W2082140286 @default.
• W2808068978 cites W2083484297 @default.
• W2808068978 cites W2107627025 @default.
• W2808068978 cites W2108555579 @default.
• W2808068978 cites W2115068541 @default.
• W2808068978 cites W2120637537 @default.
• W2808068978 cites W2128431602 @default.
• W2808068978 cites W2128600649 @default.
• W2808068978 cites W2135206837 @default.
• W2808068978 cites W2139265966 @default.
• W2808068978 cites W2141741448 @default.
• W2808068978 cites W2152505869 @default.
• W2808068978 cites W2155445009 @default.
• W2808068978 cites W2156440755 @default.
• W2808068978 cites W2238552371 @default.
• W2808068978 cites W2403671454 @default.
• W2808068978 cites W2570479665 @default.
• W2808068978 cites W2576413429 @default.
• W2808068978 cites W2622950545 @default.
• W2808068978 cites W2767927145 @default.
• W2808068978 doi "https://doi.org/10.1371/journal.pmed.1002589" @default.
• W2808068978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6086404" @default.
• W2808068978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30096137" @default.
• W2808068978 hasPublicationYear "2018" @default.
• W2808068978 type Work @default.
• W2808068978 sameAs 2808068978 @default.
• W2808068978 citedByCount "74" @default.
• W2808068978 countsByYear W28080689782018 @default.
• W2808068978 countsByYear W28080689782019 @default.
• W2808068978 countsByYear W28080689782020 @default.
• W2808068978 countsByYear W28080689782021 @default.
• W2808068978 countsByYear W28080689782022 @default.
• W2808068978 countsByYear W28080689782023 @default.
• W2808068978 crossrefType "journal-article" @default.
• W2808068978 hasAuthorship W2808068978A5010315274 @default.
• W2808068978 hasAuthorship W2808068978A5039166958 @default.
• W2808068978 hasAuthorship W2808068978A5044667291 @default.
• W2808068978 hasAuthorship W2808068978A5050583060 @default.
• W2808068978 hasAuthorship W2808068978A5051155900 @default.
• W2808068978 hasAuthorship W2808068978A5061720638 @default.
• W2808068978 hasAuthorship W2808068978A5074213191 @default.
• W2808068978 hasBestOaLocation W28080689781 @default.
• W2808068978 hasConcept C126322002 @default.
• W2808068978 hasConcept C138816342 @default.
• W2808068978 hasConcept C142462285 @default.
• W2808068978 hasConcept C142724271 @default.
• W2808068978 hasConcept C144024400 @default.
• W2808068978 hasConcept C149923435 @default.
• W2808068978 hasConcept C187212893 @default.
• W2808068978 hasConcept C199343813 @default.
• W2808068978 hasConcept C201903717 @default.
• W2808068978 hasConcept C2780553607 @default.
• W2808068978 hasConcept C2993143319 @default.
• W2808068978 hasConcept C3013748606 @default.
• W2808068978 hasConcept C38652104 @default.
• W2808068978 hasConcept C41008148 @default.
• W2808068978 hasConcept C512399662 @default.
• W2808068978 hasConcept C71924100 @default.
• W2808068978 hasConcept C72563966 @default.
• W2808068978 hasConcept C79736992 @default.
• W2808068978 hasConcept C99454951 @default.
• W2808068978 hasConceptScore W2808068978C126322002 @default.
• W2808068978 hasConceptScore W2808068978C138816342 @default.
• W2808068978 hasConceptScore W2808068978C142462285 @default.
• W2808068978 hasConceptScore W2808068978C142724271 @default.
• W2808068978 hasConceptScore W2808068978C144024400 @default.
• W2808068978 hasConceptScore W2808068978C149923435 @default.
• W2808068978 hasConceptScore W2808068978C187212893 @default.
• W2808068978 hasConceptScore W2808068978C199343813 @default.
• W2808068978 hasConceptScore W2808068978C201903717 @default.
• W2808068978 hasConceptScore W2808068978C2780553607 @default.

• next