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• W2808069008 abstract "Abstract The catalytic activity of PRC2 is central to maintain transcriptional repression by H3K27me3-decorated facultative heterochromatin in mammalian cells. To date, multiple factors have been reported to regulate PRC2 activity. Here, we demonstrate that PRC2 methylates itself on EZH1/2 and SUZ12 subunits, with EZH1/2-K514 being the major automethylation site in cells. The functional studies of automethylation on EZH2 indicate automethylation as a self-activating mechanism for PRC2 in the absence of stimulatory cofactors like AEBP2. Together, our study reveals PRC2 automethylation as a novel regulatory mechanism of PRC2 activity on chromatin." @default.
• W2808069008 created "2018-06-21" @default.
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• W2808069008 date "2018-06-17" @default.
• W2808069008 modified "2023-09-26" @default.
• W2808069008 title "Automethylation of PRC2 fine-tunes its catalytic activity on chromatin" @default.
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• W2808069008 doi "https://doi.org/10.1101/349449" @default.
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