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- W2808069516 abstract "Plant ScienceVinblastine and vincristine are important, expensive anticancer agents that are produced by dimerization of the plant-derived alkaloids catharanthine and vindoline. The enzymes that transform tabersonine into vindoline are known; however, the mechanism by which the scaffolds of catharanthine and tabersonine are generated has been a mystery. Caputi et al. now describe the biosynthetic genes and corresponding enzymes responsible. This resolves a long-standing question of how plant alkaloid scaffolds are synthesized, which is important not only for vinblastine and vincristine biosynthesis, but also for understanding the many other biologically active alkaloids found throughout nature.Science , this issue p. [1235][1] [1]: /lookup/doi/10.1126/science.aat4100" @default.
- W2808069516 created "2018-06-21" @default.
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- W2808069516 date "2018-06-14" @default.
- W2808069516 modified "2023-09-25" @default.
- W2808069516 title "How to make bioactive alkaloids" @default.
- W2808069516 doi "https://doi.org/10.1126/science.360.6394.1198-l" @default.
- W2808069516 hasPublicationYear "2018" @default.
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