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- W2808077797 abstract "The phenotypic consequences of a given mutation can vary across individuals. This so-called background effect is widely observed, from mutant fitness of loss-of-function variants in model organisms to variable disease penetrance and expressivity in humans; however, the underlying genetic basis often remains unclear. Taking insights gained from recent large-scale surveys of genetic interaction and suppression analyses in yeast, we propose that the genetic network context for a given mutation may shape its propensity of exhibiting background-dependent phenotypes. We argue that further efforts in systematically mapping the genetic interaction networks beyond yeast will provide not only key insights into the functional properties of genes, but also a better understanding of the background effects and the (un)predictability of traits in a broader context." @default.
- W2808077797 created "2018-06-21" @default.
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- W2808077797 date "2018-08-01" @default.
- W2808077797 modified "2023-10-12" @default.
- W2808077797 title "Genetic Network Complexity Shapes Background-Dependent Phenotypic Expression" @default.
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- W2808077797 doi "https://doi.org/10.1016/j.tig.2018.05.006" @default.
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