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- W2808082244 abstract "Background Treat-to-target strategies have improved outcomes in rheumatic diseases. In psoriatic arthritis (PsA), the proposed targets are the multidimensional target Minimal Disease Activity (MDA) and the articular target Disease Activity index for PsA (DAPSA). Objectives We aimed to compare burden of PsA in patients with low disease activity according to the two definitions MDA and DAPSA-Low Disease Activity (DAPSA-LDA), one year after diagnosis. Methods We obtained data on MDA, DAPSA-LDA and disease burden one year after diagnosis from patients included in the Dutch southwest early PsA cohort. Disease burden was assessed in two domains: ‘Body Functions’, including Short Form 36 Bodily Pain (SF36-BP), and ‘Activity’, including Health Assessment Questionnaire (HAQ). Results Of the 292 patients included, 48% achieved MDA and 64% DAPSA-LDA. Average ‘Body Functions’ and ‘Activity’ were similar in patients in MDA and patients in DAPSA-LDA. However the scores were significantly better in the 44% of patients in both MDA and DAPSA-LDA than in the 20% of patients only in DAPSA-LDA. The average SF36-BP was higher in patients achieving both targets (74.7, 95% CI 72.0–77.4) than in patients only in DAPSA-LDA (58.7, 95% CI 54.8–62.6). Similarly, mean HAQ scores measuring ‘Activity’ were 0.19 (95%CI 0.14–0.25) and 0.61 (95%CI 0.48–0.73) respectively. Conclusions Of patients newly diagnosed with PsA, 48% achieved MDA and 64% DAPSA-LDA after one year receiving usual care. Average disease burden was similar in patients in MDA and in patients in DAPSA-LDA. However, those that only achieved DAPSA-LDA reported worse outcomes than those also achieving MDA. Disclosure of Interest None declared" @default.
- W2808082244 created "2018-06-21" @default.
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- W2808082244 date "2018-06-01" @default.
- W2808082244 modified "2023-09-27" @default.
- W2808082244 title "THU0289 Burden of psoriatic arthritis in different definitions of disease activity: comparing minimal disease activity and disease activity index for psoriatic arthritis" @default.
- W2808082244 doi "https://doi.org/10.1136/annrheumdis-2018-eular.4578" @default.
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