Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808089905> ?p ?o ?g. }
- W2808089905 endingPage "1995" @default.
- W2808089905 startingPage "1983" @default.
- W2808089905 abstract "Primary hyperoxalurias (PHs) are autosomal recessive disorders caused by the overproduction of oxalate leading to calcium oxalate precipitation in the kidney and eventually to end-stage renal disease. One promising strategy to treat PHs is to reduce the hepatic production of oxalate through substrate reduction therapy by inhibiting liver-specific glycolate oxidase (GO), which controls the conversion of glycolate to glyoxylate, the proposed main precursor to oxalate. Alternatively, diminishing the amount of hepatic lactate dehydrogenase (LDH) expression, the proposed key enzyme responsible for converting glyoxylate to oxalate, should directly prevent the accumulation of oxalate in PH patients. Using RNAi, we provide the first in vivo evidence in mammals to support LDH as the key enzyme responsible for converting glyoxylate to oxalate. In addition, we demonstrate that reduction of hepatic LDH achieves efficient oxalate reduction and prevents calcium oxalate crystal deposition in genetically engineered mouse models of PH types 1 (PH1) and 2 (PH2), as well as in chemically induced PH mouse models. Repression of hepatic LDH in mice did not cause any acute elevation of circulating liver enzymes, lactate acidosis, or exertional myopathy, suggesting further evaluation of liver-specific inhibition of LDH as a potential approach for treating PH1 and PH2 is warranted." @default.
- W2808089905 created "2018-06-21" @default.
- W2808089905 creator A5000233841 @default.
- W2808089905 creator A5007723262 @default.
- W2808089905 creator A5009953160 @default.
- W2808089905 creator A5010028748 @default.
- W2808089905 creator A5018703558 @default.
- W2808089905 creator A5028064690 @default.
- W2808089905 creator A5029964675 @default.
- W2808089905 creator A5031224017 @default.
- W2808089905 creator A5031583663 @default.
- W2808089905 creator A5047928014 @default.
- W2808089905 creator A5070733034 @default.
- W2808089905 creator A5072778007 @default.
- W2808089905 creator A5075432938 @default.
- W2808089905 creator A5076651715 @default.
- W2808089905 creator A5077112082 @default.
- W2808089905 creator A5079274529 @default.
- W2808089905 creator A5081268637 @default.
- W2808089905 creator A5091117919 @default.
- W2808089905 date "2018-08-01" @default.
- W2808089905 modified "2023-10-11" @default.
- W2808089905 title "Specific Inhibition of Hepatic Lactate Dehydrogenase Reduces Oxalate Production in Mouse Models of Primary Hyperoxaluria" @default.
- W2808089905 cites W155011888 @default.
- W2808089905 cites W182888606 @default.
- W2808089905 cites W1964959571 @default.
- W2808089905 cites W1969123973 @default.
- W2808089905 cites W1970293316 @default.
- W2808089905 cites W1979866010 @default.
- W2808089905 cites W1979940737 @default.
- W2808089905 cites W1980726074 @default.
- W2808089905 cites W1999073835 @default.
- W2808089905 cites W2013643625 @default.
- W2808089905 cites W2026688443 @default.
- W2808089905 cites W2034509759 @default.
- W2808089905 cites W2041736283 @default.
- W2808089905 cites W2047038134 @default.
- W2808089905 cites W2047530325 @default.
- W2808089905 cites W2050252355 @default.
- W2808089905 cites W2072223844 @default.
- W2808089905 cites W2086901557 @default.
- W2808089905 cites W2088094515 @default.
- W2808089905 cites W2092725770 @default.
- W2808089905 cites W2093893918 @default.
- W2808089905 cites W2094800851 @default.
- W2808089905 cites W2098725018 @default.
- W2808089905 cites W2104665168 @default.
- W2808089905 cites W2106951882 @default.
- W2808089905 cites W2119035208 @default.
- W2808089905 cites W2142389972 @default.
- W2808089905 cites W2153545492 @default.
- W2808089905 cites W2153770792 @default.
- W2808089905 cites W2157058504 @default.
- W2808089905 cites W2160335662 @default.
- W2808089905 cites W2164103080 @default.
- W2808089905 cites W2166143354 @default.
- W2808089905 cites W2176288506 @default.
- W2808089905 cites W2195018812 @default.
- W2808089905 cites W2220036626 @default.
- W2808089905 cites W2336704411 @default.
- W2808089905 cites W2336752135 @default.
- W2808089905 cites W2496344419 @default.
- W2808089905 cites W2547201004 @default.
- W2808089905 cites W2605516567 @default.
- W2808089905 cites W4236938577 @default.
- W2808089905 doi "https://doi.org/10.1016/j.ymthe.2018.05.016" @default.
- W2808089905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6094358" @default.
- W2808089905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29914758" @default.
- W2808089905 hasPublicationYear "2018" @default.
- W2808089905 type Work @default.
- W2808089905 sameAs 2808089905 @default.
- W2808089905 citedByCount "73" @default.
- W2808089905 countsByYear W28080899052018 @default.
- W2808089905 countsByYear W28080899052019 @default.
- W2808089905 countsByYear W28080899052020 @default.
- W2808089905 countsByYear W28080899052021 @default.
- W2808089905 countsByYear W28080899052022 @default.
- W2808089905 countsByYear W28080899052023 @default.
- W2808089905 crossrefType "journal-article" @default.
- W2808089905 hasAuthorship W2808089905A5000233841 @default.
- W2808089905 hasAuthorship W2808089905A5007723262 @default.
- W2808089905 hasAuthorship W2808089905A5009953160 @default.
- W2808089905 hasAuthorship W2808089905A5010028748 @default.
- W2808089905 hasAuthorship W2808089905A5018703558 @default.
- W2808089905 hasAuthorship W2808089905A5028064690 @default.
- W2808089905 hasAuthorship W2808089905A5029964675 @default.
- W2808089905 hasAuthorship W2808089905A5031224017 @default.
- W2808089905 hasAuthorship W2808089905A5031583663 @default.
- W2808089905 hasAuthorship W2808089905A5047928014 @default.
- W2808089905 hasAuthorship W2808089905A5070733034 @default.
- W2808089905 hasAuthorship W2808089905A5072778007 @default.
- W2808089905 hasAuthorship W2808089905A5075432938 @default.
- W2808089905 hasAuthorship W2808089905A5076651715 @default.
- W2808089905 hasAuthorship W2808089905A5077112082 @default.
- W2808089905 hasAuthorship W2808089905A5079274529 @default.
- W2808089905 hasAuthorship W2808089905A5081268637 @default.
- W2808089905 hasAuthorship W2808089905A5091117919 @default.
- W2808089905 hasBestOaLocation W28080899051 @default.