Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808096741> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2808096741 endingPage "537" @default.
- W2808096741 startingPage "533" @default.
- W2808096741 abstract "It's known that long non-coding RNA CASC2 overexpression inhibit the JNK pathway in some disease models, while JNK pathway activation exacerbates diabetic nephropathy. Therefore we speculate that long non-coding RNA CASC2 can improve diabetic nephropathy by inhibiting JNK pathway. Thus, our study was carried out to investigate the involvement of CASC2 in diabetic nephropathy. We found that serum level of CASC2 was significantly lower in diabetic nephropathy patients than in normal people, and serum level of CASC2 showed no significant correlations with age, gender, alcohol consumption and smoking habits, but was correlated with course of disease. ROC curve analysis showed that serum level of CASC2 could be used to accurately predict diabetic nephropathy. Diabetes mellitus has many complications. This study also included a series of complications of diabetes, such as diabetic retinopathy, diabetic ketoacidosis, diabetic foot infections and diabetic cardiopathy, while serum level of CASC2 was specifically reduced in diabetic nephropathy. CASC2 expression level decreased, while JNK1 phosphorylation level increased in mouse podocyte cells treated with high glucose. CASC2 overexpression inhibited apoptosis of podocyte cells and reduced phosphorylation level of JNK1. We conclude that long non-coding RNA CASC2 may improve diabetic nephropathy by inhibiting JNK pathway." @default.
- W2808096741 created "2018-06-21" @default.
- W2808096741 creator A5004918031 @default.
- W2808096741 creator A5010556252 @default.
- W2808096741 creator A5036164549 @default.
- W2808096741 creator A5055831817 @default.
- W2808096741 date "2018-06-11" @default.
- W2808096741 modified "2023-10-03" @default.
- W2808096741 title "Long Non-Coding RNA CASC2 Improves Diabetic Nephropathy by Inhibiting JNK Pathway" @default.
- W2808096741 cites W1991389049 @default.
- W2808096741 cites W2001978797 @default.
- W2808096741 cites W2004406516 @default.
- W2808096741 cites W2043873569 @default.
- W2808096741 cites W2124050695 @default.
- W2808096741 cites W2147996486 @default.
- W2808096741 cites W2162368776 @default.
- W2808096741 cites W2323155807 @default.
- W2808096741 cites W2395535932 @default.
- W2808096741 cites W2405615126 @default.
- W2808096741 cites W2525587647 @default.
- W2808096741 cites W2561585152 @default.
- W2808096741 cites W2578265367 @default.
- W2808096741 cites W2604394085 @default.
- W2808096741 cites W2642600831 @default.
- W2808096741 doi "https://doi.org/10.1055/a-0629-9958" @default.
- W2808096741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29890555" @default.
- W2808096741 hasPublicationYear "2018" @default.
- W2808096741 type Work @default.
- W2808096741 sameAs 2808096741 @default.
- W2808096741 citedByCount "20" @default.
- W2808096741 countsByYear W28080967412019 @default.
- W2808096741 countsByYear W28080967412020 @default.
- W2808096741 countsByYear W28080967412021 @default.
- W2808096741 countsByYear W28080967412022 @default.
- W2808096741 countsByYear W28080967412023 @default.
- W2808096741 crossrefType "journal-article" @default.
- W2808096741 hasAuthorship W2808096741A5004918031 @default.
- W2808096741 hasAuthorship W2808096741A5010556252 @default.
- W2808096741 hasAuthorship W2808096741A5036164549 @default.
- W2808096741 hasAuthorship W2808096741A5055831817 @default.
- W2808096741 hasConcept C104317684 @default.
- W2808096741 hasConcept C126322002 @default.
- W2808096741 hasConcept C127561419 @default.
- W2808096741 hasConcept C134018914 @default.
- W2808096741 hasConcept C2777146197 @default.
- W2808096741 hasConcept C2779561371 @default.
- W2808096741 hasConcept C2779922275 @default.
- W2808096741 hasConcept C2780091579 @default.
- W2808096741 hasConcept C2781184683 @default.
- W2808096741 hasConcept C55493867 @default.
- W2808096741 hasConcept C555293320 @default.
- W2808096741 hasConcept C62203573 @default.
- W2808096741 hasConcept C71924100 @default.
- W2808096741 hasConcept C86803240 @default.
- W2808096741 hasConceptScore W2808096741C104317684 @default.
- W2808096741 hasConceptScore W2808096741C126322002 @default.
- W2808096741 hasConceptScore W2808096741C127561419 @default.
- W2808096741 hasConceptScore W2808096741C134018914 @default.
- W2808096741 hasConceptScore W2808096741C2777146197 @default.
- W2808096741 hasConceptScore W2808096741C2779561371 @default.
- W2808096741 hasConceptScore W2808096741C2779922275 @default.
- W2808096741 hasConceptScore W2808096741C2780091579 @default.
- W2808096741 hasConceptScore W2808096741C2781184683 @default.
- W2808096741 hasConceptScore W2808096741C55493867 @default.
- W2808096741 hasConceptScore W2808096741C555293320 @default.
- W2808096741 hasConceptScore W2808096741C62203573 @default.
- W2808096741 hasConceptScore W2808096741C71924100 @default.
- W2808096741 hasConceptScore W2808096741C86803240 @default.
- W2808096741 hasIssue "08" @default.
- W2808096741 hasLocation W28080967411 @default.
- W2808096741 hasLocation W28080967412 @default.
- W2808096741 hasOpenAccess W2808096741 @default.
- W2808096741 hasPrimaryLocation W28080967411 @default.
- W2808096741 hasRelatedWork W2020449916 @default.
- W2808096741 hasRelatedWork W2032111989 @default.
- W2808096741 hasRelatedWork W2038657938 @default.
- W2808096741 hasRelatedWork W2047956456 @default.
- W2808096741 hasRelatedWork W2061728276 @default.
- W2808096741 hasRelatedWork W2104195310 @default.
- W2808096741 hasRelatedWork W2134392906 @default.
- W2808096741 hasRelatedWork W2406277046 @default.
- W2808096741 hasRelatedWork W2589426237 @default.
- W2808096741 hasRelatedWork W2808096741 @default.
- W2808096741 hasVolume "127" @default.
- W2808096741 isParatext "false" @default.
- W2808096741 isRetracted "false" @default.
- W2808096741 magId "2808096741" @default.
- W2808096741 workType "article" @default.