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- W2808098518 abstract "BACKGROUND :Serum leptin has been implicated in pathogenesis of asthma with contradicting resultsfrom various studies. We aimed at evaluating the influence of serum leptin on asthma control andquality of life among adults.METHODS : In all, 60 asthmatics were recruited prospectively and interviewed with Juniper’sAsthma control questionnaire (ACQ) and Asthma specific quality of life questionnaire(AQLQ).Clinico demographic DATA were collected from all subjects who also underwent spirometryand estimation of leptin in fasting serum. A well controlled asthma was defined by > 1.5 score inACQ.RESULTS : The study population had a mean age of 37.8 +15.3 years and BMI 24.04+4.16Kgs/m^2.Thirty five (58.3% ) subjects were females, Asthma was well controlled in 17(28.3%)subjects. Among the clinical and demographic characteristics of our subjects ,only the use ofinhaled steroids at higher dose was associated with well controlled asthma (adjusted odds ratio5.635(1.323 – 24.0);P =0.019.Serum leptin was not different between subjects with wellcontrolled and uncontrolled asthma. 30.5 +21.8 ng/ml respectively; P >0.05,however serumleptin correlated modestly with BMI (r ^2=0.302,p=0.019),AQLQ total score(r=0.256;p=0.049)AQLQ activity domain (r = 0.274,p=0.034) and AQLQ symptom domain(r=0.253,p=0.05)CONCLUSION : Serum leptin appears to have no association with asthma control in our smallsample of adults. Its modest correlation with activity and symptom domains of quality of lifewarrants further investigation." @default.
- W2808098518 created "2018-06-21" @default.
- W2808098518 creator A5078095506 @default.
- W2808098518 date "2017-04-01" @default.
- W2808098518 modified "2023-09-27" @default.
- W2808098518 title "A Study on Influence of Serum Leptin over Asthma Control and Asthma Related Quality Of Life" @default.
- W2808098518 hasPublicationYear "2017" @default.
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