FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808098739> ?p ?o ?g. }

• W2808098739 endingPage "108" @default.
• W2808098739 startingPage "90" @default.
• W2808098739 abstract "Hydrogen sulfide (H2S) is a novel gasotransmitter produced endogenously in mammalian cells, which works by mediating diverse physiological functions. An imbalance in H2S metabolism is associated with defective bone homeostasis. However, it is unknown whether H2S plays any epigenetic role in bone loss induced by hyperhomocysteinemia (HHcy). We demonstrate that diet-induced HHcy, a mouse model of metabolite induced osteoporosis, alters homocysteine metabolism by decreasing plasma levels of H2S. Treatment with NaHS (H2S donor), normalizes the plasma level of H2S and further alleviates HHcy induced trabecular bone loss and mechanical strength. Mechanistic studies have shown that DNMT1 expression is higher in the HHcy condition. The data show that activated phospho-JNK binds to the DNMT1 promoter and causes epigenetic DNA hyper-methylation of the OPG gene. This leads to activation of RANKL expression and mediates osteoclastogenesis. However, administration of NaHS could prevent HHcy induced bone loss. Therefore, H2S could be used as a novel therapy for HHcy mediated bone loss." @default.
• W2808098739 created "2018-06-21" @default.
• W2808098739 creator A5003454740 @default.
• W2808098739 creator A5007554234 @default.
• W2808098739 creator A5026631602 @default.
• W2808098739 creator A5042067410 @default.
• W2808098739 creator A5051938836 @default.
• W2808098739 date "2018-09-01" @default.
• W2808098739 modified "2023-10-12" @default.
• W2808098739 title "Hydrogen sulfide epigenetically mitigates bone loss through OPG/RANKL regulation during hyperhomocysteinemia in mice" @default.
• W2808098739 cites W1598953200 @default.
• W2808098739 cites W1636028712 @default.
• W2808098739 cites W1965262464 @default.
• W2808098739 cites W1965318110 @default.
• W2808098739 cites W1965917092 @default.
• W2808098739 cites W1967727444 @default.
• W2808098739 cites W1976743580 @default.
• W2808098739 cites W1978260154 @default.
• W2808098739 cites W2002831974 @default.
• W2808098739 cites W2003027140 @default.
• W2808098739 cites W2004897596 @default.
• W2808098739 cites W2005379074 @default.
• W2808098739 cites W2006950202 @default.
• W2808098739 cites W2014641242 @default.
• W2808098739 cites W2020823204 @default.
• W2808098739 cites W2022146837 @default.
• W2808098739 cites W2024672608 @default.
• W2808098739 cites W2036186534 @default.
• W2808098739 cites W2040196938 @default.
• W2808098739 cites W2042577535 @default.
• W2808098739 cites W2042577582 @default.
• W2808098739 cites W2052060592 @default.
• W2808098739 cites W2054847530 @default.
• W2808098739 cites W2060897077 @default.
• W2808098739 cites W2070478570 @default.
• W2808098739 cites W2073472143 @default.
• W2808098739 cites W2081460287 @default.
• W2808098739 cites W2090997879 @default.
• W2808098739 cites W2092239360 @default.
• W2808098739 cites W2093349314 @default.
• W2808098739 cites W2093879648 @default.
• W2808098739 cites W2099007490 @default.
• W2808098739 cites W2099343472 @default.
• W2808098739 cites W2101930392 @default.
• W2808098739 cites W2104090398 @default.
• W2808098739 cites W2114022957 @default.
• W2808098739 cites W2116224636 @default.
• W2808098739 cites W2120464741 @default.
• W2808098739 cites W2123346255 @default.
• W2808098739 cites W2128816394 @default.
• W2808098739 cites W2131938977 @default.
• W2808098739 cites W2137794345 @default.
• W2808098739 cites W2139122477 @default.
• W2808098739 cites W2139737762 @default.
• W2808098739 cites W2153365782 @default.
• W2808098739 cites W2158078567 @default.
• W2808098739 cites W2160296469 @default.
• W2808098739 cites W2172161196 @default.
• W2808098739 cites W2173887048 @default.
• W2808098739 cites W2175273589 @default.
• W2808098739 cites W2271567759 @default.
• W2808098739 cites W2318665202 @default.
• W2808098739 cites W2419935436 @default.
• W2808098739 cites W2559767757 @default.
• W2808098739 cites W2562416289 @default.
• W2808098739 cites W2588456342 @default.
• W2808098739 cites W2754006633 @default.
• W2808098739 doi "https://doi.org/10.1016/j.bone.2018.06.009" @default.
• W2808098739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6084464" @default.
• W2808098739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29908298" @default.
• W2808098739 hasPublicationYear "2018" @default.
• W2808098739 type Work @default.
• W2808098739 sameAs 2808098739 @default.
• W2808098739 citedByCount "60" @default.
• W2808098739 countsByYear W28080987392018 @default.
• W2808098739 countsByYear W28080987392019 @default.
• W2808098739 countsByYear W28080987392020 @default.
• W2808098739 countsByYear W28080987392021 @default.
• W2808098739 countsByYear W28080987392022 @default.
• W2808098739 countsByYear W28080987392023 @default.
• W2808098739 crossrefType "journal-article" @default.
• W2808098739 hasAuthorship W2808098739A5003454740 @default.
• W2808098739 hasAuthorship W2808098739A5007554234 @default.
• W2808098739 hasAuthorship W2808098739A5026631602 @default.
• W2808098739 hasAuthorship W2808098739A5042067410 @default.
• W2808098739 hasAuthorship W2808098739A5051938836 @default.
• W2808098739 hasBestOaLocation W28080987391 @default.
• W2808098739 hasConcept C104317684 @default.
• W2808098739 hasConcept C126322002 @default.
• W2808098739 hasConcept C134018914 @default.
• W2808098739 hasConcept C150194340 @default.
• W2808098739 hasConcept C16525657 @default.
• W2808098739 hasConcept C170033053 @default.
• W2808098739 hasConcept C170493617 @default.
• W2808098739 hasConcept C181199279 @default.
• W2808098739 hasConcept C185592680 @default.
• W2808098739 hasConcept C190727270 @default.
• W2808098739 hasConcept C2776523773 @default.

• next