Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808099989> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2808099989 endingPage "189" @default.
- W2808099989 startingPage "184" @default.
- W2808099989 abstract "Acne vulgaris is a common chronic skin disease. Inflammation is an important pathogenetic mechanism of acne, and NLRP3 polymorphisms have been reported to be involved in the mediation and occurrence of the inflammation. However, only a few studies on NLRP3 and acne have been reported, and the mechanism remains unclear.To investigate two SNPs in the NLRP3 gene in patients with acne vulgaris (AV) and healthy controls (HCs) in a Chinese population.A case-control study was performed with 428 patients with AV and 384 (HCs). The SNPs rs10754558 and rs4612666 of the NLRP3 gene were genotyped using PCR with sequence-specific primers. A dual luciferase reporter assay was performed to determine whether the SNP rs10754558 might be responsible for the altered NLRP3 gene expression in AV by disrupting the interaction between micro-RNA (miR)-4273 and NLRP3 mRNA. Additionally, the mRNA level of NLRP3 was measured by PCR in the two groups.The frequencies of the G allele of rs10754558 were 0.54 in patients and 0.49 in HCs (P < 0.05). No significant difference was observed for SNP rs4612666. Dual luciferase reporter assay revealed that luciferase activity was downregulated by about 40% when the G allele of rs10754558 coexisted with miRNA-4273, indicating that the G allele might interfere with miR-4273 function and alter NLRP3 expression. The level of NLRP3 mRNA in patients with AV was significantly higher than that in HCs.Our study suggests that the NLRP3 SNP rs10754558 is associated with the incidence of AV. The G allele might be a genetic risk factor for AV in the Chinese population." @default.
- W2808099989 created "2018-06-21" @default.
- W2808099989 creator A5021149486 @default.
- W2808099989 creator A5026108500 @default.
- W2808099989 creator A5038727142 @default.
- W2808099989 creator A5048108600 @default.
- W2808099989 creator A5055174666 @default.
- W2808099989 creator A5066987126 @default.
- W2808099989 creator A5089043739 @default.
- W2808099989 date "2018-06-11" @default.
- W2808099989 modified "2023-09-30" @default.
- W2808099989 title "Genetic association between the <i>NLRP3</i> gene and acne vulgaris in a Chinese population" @default.
- W2808099989 cites W1889513498 @default.
- W2808099989 cites W1971883262 @default.
- W2808099989 cites W1994012874 @default.
- W2808099989 cites W1994816987 @default.
- W2808099989 cites W2002195076 @default.
- W2808099989 cites W2007512675 @default.
- W2808099989 cites W2014665497 @default.
- W2808099989 cites W2014716916 @default.
- W2808099989 cites W2018020430 @default.
- W2808099989 cites W2034946303 @default.
- W2808099989 cites W2042861376 @default.
- W2808099989 cites W2057519809 @default.
- W2808099989 cites W2073645715 @default.
- W2808099989 cites W2085244995 @default.
- W2808099989 cites W2094152866 @default.
- W2808099989 cites W2137237823 @default.
- W2808099989 cites W2145301387 @default.
- W2808099989 cites W2161038680 @default.
- W2808099989 cites W2162674813 @default.
- W2808099989 cites W2297605622 @default.
- W2808099989 cites W2339415213 @default.
- W2808099989 cites W4211104405 @default.
- W2808099989 doi "https://doi.org/10.1111/ced.13657" @default.
- W2808099989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29888470" @default.
- W2808099989 hasPublicationYear "2018" @default.
- W2808099989 type Work @default.
- W2808099989 sameAs 2808099989 @default.
- W2808099989 citedByCount "15" @default.
- W2808099989 countsByYear W28080999892020 @default.
- W2808099989 countsByYear W28080999892021 @default.
- W2808099989 countsByYear W28080999892022 @default.
- W2808099989 countsByYear W28080999892023 @default.
- W2808099989 crossrefType "journal-article" @default.
- W2808099989 hasAuthorship W2808099989A5021149486 @default.
- W2808099989 hasAuthorship W2808099989A5026108500 @default.
- W2808099989 hasAuthorship W2808099989A5038727142 @default.
- W2808099989 hasAuthorship W2808099989A5048108600 @default.
- W2808099989 hasAuthorship W2808099989A5055174666 @default.
- W2808099989 hasAuthorship W2808099989A5066987126 @default.
- W2808099989 hasAuthorship W2808099989A5089043739 @default.
- W2808099989 hasConcept C101762097 @default.
- W2808099989 hasConcept C104317684 @default.
- W2808099989 hasConcept C135763542 @default.
- W2808099989 hasConcept C139275648 @default.
- W2808099989 hasConcept C150194340 @default.
- W2808099989 hasConcept C153209595 @default.
- W2808099989 hasConcept C153911025 @default.
- W2808099989 hasConcept C180754005 @default.
- W2808099989 hasConcept C2777673923 @default.
- W2808099989 hasConcept C54355233 @default.
- W2808099989 hasConcept C86803240 @default.
- W2808099989 hasConceptScore W2808099989C101762097 @default.
- W2808099989 hasConceptScore W2808099989C104317684 @default.
- W2808099989 hasConceptScore W2808099989C135763542 @default.
- W2808099989 hasConceptScore W2808099989C139275648 @default.
- W2808099989 hasConceptScore W2808099989C150194340 @default.
- W2808099989 hasConceptScore W2808099989C153209595 @default.
- W2808099989 hasConceptScore W2808099989C153911025 @default.
- W2808099989 hasConceptScore W2808099989C180754005 @default.
- W2808099989 hasConceptScore W2808099989C2777673923 @default.
- W2808099989 hasConceptScore W2808099989C54355233 @default.
- W2808099989 hasConceptScore W2808099989C86803240 @default.
- W2808099989 hasFunder F4320321885 @default.
- W2808099989 hasFunder F4320326187 @default.
- W2808099989 hasIssue "2" @default.
- W2808099989 hasLocation W28080999891 @default.
- W2808099989 hasLocation W28080999892 @default.
- W2808099989 hasOpenAccess W2808099989 @default.
- W2808099989 hasPrimaryLocation W28080999891 @default.
- W2808099989 hasRelatedWork W2056355462 @default.
- W2808099989 hasRelatedWork W2057739827 @default.
- W2808099989 hasRelatedWork W2107074164 @default.
- W2808099989 hasRelatedWork W2161110446 @default.
- W2808099989 hasRelatedWork W2223919059 @default.
- W2808099989 hasRelatedWork W2283861756 @default.
- W2808099989 hasRelatedWork W2358154819 @default.
- W2808099989 hasRelatedWork W2790470715 @default.
- W2808099989 hasRelatedWork W3030331178 @default.
- W2808099989 hasRelatedWork W3055258070 @default.
- W2808099989 hasVolume "44" @default.
- W2808099989 isParatext "false" @default.
- W2808099989 isRetracted "false" @default.
- W2808099989 magId "2808099989" @default.
- W2808099989 workType "article" @default.