FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808101176> ?p ?o ?g. }

• W2808101176 endingPage "457" @default.
• W2808101176 startingPage "437" @default.
• W2808101176 abstract "Epstein-Barr virus-associated gastric cancer (EBVaGC) is a representative EBV-infected epithelial neoplasm, which is now included as one of the four subtypes of The Cancer Genome Atlas molecular classification of gastric cancer. In this review, we portray a gastritis-infection-cancer sequence of EBVaGC. This virus-associated type of gastric cancer demonstrates clonal growth of EBV-infected epithelial cells within the mucosa of atrophic gastritis. Its core molecular abnormality is the EBV-specific hyper-epigenotype of CpG island promoter methylation, which induces silencing of tumor suppressor genes. This is due to the infection-induced disruption of the balance between DNA methylation and DNA demethylation activities. Abnormalities in the host cell genome, including phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit α (PIK3CA), AT-rich interaction domain 1A (ARID1A), and programmed death-ligand 1 (PD-L1), are associated with the development and progression of EBVaGC. Furthermore, posttranscriptional modulation affects the transformation processes of EBV-infected cells, such as epithelial mesenchymal transition and anti-apoptosis, via cellular and viral microRNAs (miRNAs). Once established, cancer cells of EBVaGC remodel their microenvironment, at least partly, via the delivery of exosomes containing cellular and viral miRNAs. After exosomes are incorporated, these molecules change the functions of stromal cells, tuning the microenvironment for EBVaGC. During this series of events, EBV hijacks and uses cellular machineries, such as DNA methylation and the miRNA delivery system. This portrait of gastritis-infection-cancer sequences highlights the survival strategies of EBV in the stomach epithelial cells and may be useful for the integration of therapeutic modalities against EBV-driven gastric cancer." @default.
• W2808101176 created "2018-06-21" @default.
• W2808101176 creator A5005708651 @default.
• W2808101176 creator A5046301056 @default.
• W2808101176 creator A5081519082 @default.
• W2808101176 date "2018-01-01" @default.
• W2808101176 modified "2023-10-12" @default.
• W2808101176 title "Gastritis-Infection-Cancer Sequence of Epstein-Barr Virus-Associated Gastric Cancer" @default.
• W2808101176 cites W1251040443 @default.
• W2808101176 cites W1578530056 @default.
• W2808101176 cites W1593352795 @default.
• W2808101176 cites W1908203552 @default.
• W2808101176 cites W1926326783 @default.
• W2808101176 cites W1964230671 @default.
• W2808101176 cites W1968120911 @default.
• W2808101176 cites W1971542939 @default.
• W2808101176 cites W1973215894 @default.
• W2808101176 cites W1973720271 @default.
• W2808101176 cites W1996955003 @default.
• W2808101176 cites W2007490905 @default.
• W2808101176 cites W2008062656 @default.
• W2808101176 cites W2015373949 @default.
• W2808101176 cites W2016870031 @default.
• W2808101176 cites W2018292960 @default.
• W2808101176 cites W2020639373 @default.
• W2808101176 cites W2023269331 @default.
• W2808101176 cites W2029902819 @default.
• W2808101176 cites W2032548081 @default.
• W2808101176 cites W2036194572 @default.
• W2808101176 cites W2041983142 @default.
• W2808101176 cites W2046690351 @default.
• W2808101176 cites W2050053985 @default.
• W2808101176 cites W2053825411 @default.
• W2808101176 cites W2054097842 @default.
• W2808101176 cites W2054186703 @default.
• W2808101176 cites W2076315676 @default.
• W2808101176 cites W2077356409 @default.
• W2808101176 cites W2078658653 @default.
• W2808101176 cites W2080817801 @default.
• W2808101176 cites W2081575679 @default.
• W2808101176 cites W2084393590 @default.
• W2808101176 cites W2086775982 @default.
• W2808101176 cites W2090638860 @default.
• W2808101176 cites W2097126123 @default.
• W2808101176 cites W2097575860 @default.
• W2808101176 cites W2104181329 @default.
• W2808101176 cites W2107976675 @default.
• W2808101176 cites W2115503551 @default.
• W2808101176 cites W2116078904 @default.
• W2808101176 cites W2120326887 @default.
• W2808101176 cites W2120436117 @default.
• W2808101176 cites W2126234119 @default.
• W2808101176 cites W2126547130 @default.
• W2808101176 cites W2135784953 @default.
• W2808101176 cites W2137409417 @default.
• W2808101176 cites W2139159276 @default.
• W2808101176 cites W2143563122 @default.
• W2808101176 cites W2148565455 @default.
• W2808101176 cites W2149612630 @default.
• W2808101176 cites W2158306917 @default.
• W2808101176 cites W2159278398 @default.
• W2808101176 cites W2160703133 @default.
• W2808101176 cites W2160818858 @default.
• W2808101176 cites W2177421993 @default.
• W2808101176 cites W2253662819 @default.
• W2808101176 cites W2275238760 @default.
• W2808101176 cites W2278513493 @default.
• W2808101176 cites W2283322947 @default.
• W2808101176 cites W2299059283 @default.
• W2808101176 cites W2315767088 @default.
• W2808101176 cites W2321006835 @default.
• W2808101176 cites W2342063694 @default.
• W2808101176 cites W2345542198 @default.
• W2808101176 cites W2407603036 @default.
• W2808101176 cites W2409688722 @default.
• W2808101176 cites W2432523002 @default.
• W2808101176 cites W2439998561 @default.
• W2808101176 cites W2469605883 @default.
• W2808101176 cites W2513900432 @default.
• W2808101176 cites W2534186331 @default.
• W2808101176 cites W2549050625 @default.
• W2808101176 cites W2550457904 @default.
• W2808101176 cites W2560348430 @default.
• W2808101176 cites W2572438339 @default.
• W2808101176 cites W2605422674 @default.
• W2808101176 cites W2739139903 @default.
• W2808101176 doi "https://doi.org/10.1007/978-981-10-7230-7_20" @default.
• W2808101176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29896679" @default.
• W2808101176 hasPublicationYear "2018" @default.
• W2808101176 type Work @default.
• W2808101176 sameAs 2808101176 @default.
• W2808101176 citedByCount "17" @default.
• W2808101176 countsByYear W28081011762018 @default.
• W2808101176 countsByYear W28081011762019 @default.
• W2808101176 countsByYear W28081011762020 @default.
• W2808101176 countsByYear W28081011762021 @default.
• W2808101176 countsByYear W28081011762022 @default.
• W2808101176 crossrefType "book-chapter" @default.

• next