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- W2808106220 abstract "In this paper, we are interested in the design of a microfluidic mixer based on hydrodynamic focusing which is used to initiate the folding process (i.e., changes of the molecular structure) of a protein by diluting a protein solution to decrease its denaturant concentration to a given value in a short time interval we refer to as mixing time. Our objective is to optimize this mixer by choosing suitable shape and flow conditions in order to minimize its mixing time. To this end, we first introduce a numerical model that enables computation of the mixing time of a considered mixer. Then, we define a mixer optimization problem and solve it using a hybrid global optimization algorithm." @default.
- W2808106220 created "2018-06-21" @default.
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- W2808106220 date "2017-01-01" @default.
- W2808106220 modified "2023-10-02" @default.
- W2808106220 title "Modeling and Optimization Applied to the Design of Fast Hydrodynamic Focusing Microfluidic Mixer for Protein Folding" @default.
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- W2808106220 doi "https://doi.org/10.1007/978-3-319-63082-3_98" @default.
- W2808106220 hasPublicationYear "2017" @default.
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