FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808118052> ?p ?o ?g. }

• W2808118052 endingPage "108" @default.
• W2808118052 startingPage "99" @default.
• W2808118052 abstract "Serotonin is a critical monoamine neurotransmitter molecule stored and released from enterochromaffin (EC) cells into the gut submucosa, transmitting the vomiting signal to the brain. We studied one mechanism by which vomiting is induced in pigs infected with porcine epidemic diarrhea virus (PEDV) by characterization of swine EC cells by immunohistochemistry. Conventional or gnotobiotic (Gn) 9-day-old pigs [PEDV-inoculated (n = 12); Mock (n = 14)] were inoculated orally (8.9-9.2 log10 genomic equivalents/pig) with PEDV PC21A strain or mock. This is the first identification of serotonin-positive EC cells in swine by immunohistochemistry and mainly in intestinal crypts, regardless of infection status. They were morphologically triangular-shaped or round cells with or without apical cytoplasmic extensions, respectively. At post-inoculation hour (PIH) 16 or 24, when vomiting was first or frequently observed, respectively, PEDV infection resulted in significantly reduced numbers of serotonin-positive EC cells in duodenum, mid-jejunum, ileum, or colon. However, two of three PEDV-inoculated Gn pigs that did not yet show vomiting at PIH 16 had numbers of serotonin-positive EC cells in duodenum, ileum and colon similar to those in the negative controls. These findings suggest that serotonin release from EC cells (increased serotonin levels) into the gut submucosa might occur early PEDV post-infection to stimulate the vagal afferent neurons, followed by vomiting. Serotonin might be involved in the mechanisms related to vomiting in PEDV-infected piglets. We also found that mid-jejunum was the primary site of acute PEDV infection, and that systemic innate and pro-inflammatory cytokine responses were induced during the acute stage of PEDV infection." @default.
• W2808118052 created "2018-06-21" @default.
• W2808118052 creator A5006297457 @default.
• W2808118052 creator A5064559752 @default.
• W2808118052 creator A5065315323 @default.
• W2808118052 date "2018-08-01" @default.
• W2808118052 modified "2023-10-17" @default.
• W2808118052 title "Immunohistochemical detection of the vomiting-inducing monoamine neurotransmitter serotonin and enterochromaffin cells in the intestines of conventional or gnotobiotic (Gn) pigs infected with porcine epidemic diarrhea virus (PEDV) and serum cytokine responses of Gn pigs to acute PEDV infection" @default.
• W2808118052 cites W1984181078 @default.
• W2808118052 cites W1991843444 @default.
• W2808118052 cites W2006447599 @default.
• W2808118052 cites W2007666404 @default.
• W2808118052 cites W2011424578 @default.
• W2808118052 cites W2029302646 @default.
• W2808118052 cites W2032409964 @default.
• W2808118052 cites W2033253360 @default.
• W2808118052 cites W2084387345 @default.
• W2808118052 cites W2100969166 @default.
• W2808118052 cites W2118037136 @default.
• W2808118052 cites W2123468521 @default.
• W2808118052 cites W2168457616 @default.
• W2808118052 cites W2170171527 @default.
• W2808118052 cites W2172178713 @default.
• W2808118052 cites W2233577420 @default.
• W2808118052 cites W2292371441 @default.
• W2808118052 cites W2304423786 @default.
• W2808118052 cites W2401773909 @default.
• W2808118052 cites W2417665470 @default.
• W2808118052 cites W2616453403 @default.
• W2808118052 doi "https://doi.org/10.1016/j.rvsc.2018.06.009" @default.
• W2808118052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7111759" @default.
• W2808118052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29909130" @default.
• W2808118052 hasPublicationYear "2018" @default.
• W2808118052 type Work @default.
• W2808118052 sameAs 2808118052 @default.
• W2808118052 citedByCount "27" @default.
• W2808118052 countsByYear W28081180522019 @default.
• W2808118052 countsByYear W28081180522020 @default.
• W2808118052 countsByYear W28081180522021 @default.
• W2808118052 countsByYear W28081180522022 @default.
• W2808118052 countsByYear W28081180522023 @default.
• W2808118052 crossrefType "journal-article" @default.
• W2808118052 hasAuthorship W2808118052A5006297457 @default.
• W2808118052 hasAuthorship W2808118052A5064559752 @default.
• W2808118052 hasAuthorship W2808118052A5065315323 @default.
• W2808118052 hasBestOaLocation W28081180521 @default.
• W2808118052 hasConcept C126322002 @default.
• W2808118052 hasConcept C134018914 @default.
• W2808118052 hasConcept C170493617 @default.
• W2808118052 hasConcept C203014093 @default.
• W2808118052 hasConcept C2522874641 @default.
• W2808118052 hasConcept C2775862345 @default.
• W2808118052 hasConcept C2775864247 @default.
• W2808118052 hasConcept C2776366702 @default.
• W2808118052 hasConcept C2776809568 @default.
• W2808118052 hasConcept C2777226302 @default.
• W2808118052 hasConcept C2779052585 @default.
• W2808118052 hasConcept C2780852908 @default.
• W2808118052 hasConcept C71924100 @default.
• W2808118052 hasConcept C86803240 @default.
• W2808118052 hasConcept C90423213 @default.
• W2808118052 hasConceptScore W2808118052C126322002 @default.
• W2808118052 hasConceptScore W2808118052C134018914 @default.
• W2808118052 hasConceptScore W2808118052C170493617 @default.
• W2808118052 hasConceptScore W2808118052C203014093 @default.
• W2808118052 hasConceptScore W2808118052C2522874641 @default.
• W2808118052 hasConceptScore W2808118052C2775862345 @default.
• W2808118052 hasConceptScore W2808118052C2775864247 @default.
• W2808118052 hasConceptScore W2808118052C2776366702 @default.
• W2808118052 hasConceptScore W2808118052C2776809568 @default.
• W2808118052 hasConceptScore W2808118052C2777226302 @default.
• W2808118052 hasConceptScore W2808118052C2779052585 @default.
• W2808118052 hasConceptScore W2808118052C2780852908 @default.
• W2808118052 hasConceptScore W2808118052C71924100 @default.
• W2808118052 hasConceptScore W2808118052C86803240 @default.
• W2808118052 hasConceptScore W2808118052C90423213 @default.
• W2808118052 hasFunder F4320309374 @default.
• W2808118052 hasFunder F4320332998 @default.
• W2808118052 hasLocation W28081180521 @default.
• W2808118052 hasLocation W28081180522 @default.
• W2808118052 hasLocation W28081180523 @default.
• W2808118052 hasLocation W28081180524 @default.
• W2808118052 hasOpenAccess W2808118052 @default.
• W2808118052 hasPrimaryLocation W28081180521 @default.
• W2808118052 hasRelatedWork W2011572455 @default.
• W2808118052 hasRelatedWork W2113117364 @default.
• W2808118052 hasRelatedWork W2380891382 @default.
• W2808118052 hasRelatedWork W2385653325 @default.
• W2808118052 hasRelatedWork W2578591505 @default.
• W2808118052 hasRelatedWork W2592184306 @default.
• W2808118052 hasRelatedWork W2944880462 @default.
• W2808118052 hasRelatedWork W3183446645 @default.
• W2808118052 hasRelatedWork W3208393797 @default.
• W2808118052 hasRelatedWork W4385711163 @default.
• W2808118052 hasVolume "119" @default.
• W2808118052 isParatext "false" @default.
• W2808118052 isRetracted "false" @default.
• W2808118052 magId "2808118052" @default.

• next