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- W2808128776 abstract "Objectives To study the disease characteristics, autoantibodies and activity in granulomatosis with polyangiitis (GPA) patients with ocular manifestations. Methods 46 GPA patients visiting the ophthalmology clinic were included. Ocular manifestations, clinical and slit lamp examination were performed. The Birmingham Vasculitis Activity Score (BVAS) was recorded. Laboratory investigations were recorded and the antineutrophil cytoplasmic antibody (ANCA) performed. Results The median age of the patients was 44.5 (32–63) years, 22 males:24 females and disease duration 6.5 (1–16) years. Ocular manifestations were present in all patients; 12 (26.1%) had proptosis, 40 (87%) scleritis/episcleritis with perforation in 3 (6.5%), keratoconjunctivitis in 33 (71.7%) – acute infiltrative stromal keratitis in 11, peripheral ulcerative keratitis in 15 and sclerosing keratitis in 11 patients. Uveitis was present in 11 (23.9%) and retinal changes included vasculitis, exudates and haemorrhage was present in 7 (15.2%). 43 (93.5% of the patients had blurring of vision and vision loss was present in 2 (4.3%). Glaucoma was present in 4 (8.7%) and hypotony in 2 (4.3%). Involvement was bilateral in 32 (69.6%) patients. Rheumatoid factor was positive in 56.5% and significantly associated with uveitis (p=0.04) while ANA was positive in 45.7% and significantly associated with keratoconjuctivitis (p=0.04). BVAS tended to be higher in those with uveitis (p=0.05). Conclusions Ocular involvement must be considered in all GPA patients and referral to an experienced ophthalmologist is mandatory for proper management and improved outcome of such a rare systemic disease. ANA and RF positivity may raise suspicion for KC or uveitis respectively. There was a remarkable association between uveitis and disease activity. Disclosure of Interest None declared" @default.
- W2808128776 created "2018-06-21" @default.
- W2808128776 creator A5049740641 @default.
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- W2808128776 date "2018-06-01" @default.
- W2808128776 modified "2023-09-26" @default.
- W2808128776 title "AB0706 Ocular presentation in granulomatosis with polyangiitis (GPA) patients: relation to autoantibodies and disease activity" @default.
- W2808128776 doi "https://doi.org/10.1136/annrheumdis-2018-eular.5230" @default.
- W2808128776 hasPublicationYear "2018" @default.
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