FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808141285> ?p ?o ?g. }

• W2808141285 abstract "We discuss methods for comparing effects of two treatments A and B. We investigatethe performance of response-adaptive (RA) and covariate-adjusted response-adaptive(CARA) designs in multi-center clinical trials. First, we discuss applying RA designsto maximize the well-being of participating patients in multi-center clinical trials. Weassume that the centers are selected from a large population of centers and develop ageneralized linear mixed model (GLMM) to examine the treatment effect. The asymptoticproperties of the maximum likelihood (ML) estimators of model parameters arederived using the inuence function method. We verified their theoretical propertiesthrough simulation studies. The techniques are then applied to a real data that wereobtained from a multi-center clinical trial designed to compare two cream preparations(active drug/control) for treating an infection. Secondly, we investigate the efficiency for estimates of model parameters and ethics for participating patients amongRA, CARA, and completely randomized (CR) designs for a generalized linear model(GLM). We consider the logit model to measure efficiency and ethics. Furthermore,we showed that ML estimators of GLM parameters are consistent and asymptoticallyfollow multivariate normal distribution for adaptive designs. A simulation study wasconducted to verify these theoretical results. Finally, we provide a justification of whyasymptotic results for Wald-type tests for adaptive designs can be used. We provedthat the choice of adaptive designs affects the statistical power of hypothesis testingvia these quantities: the target allocation proportion, the bias of the randomizationprocedure from the target, and the variability induced by the randomization process.Moreover, we showed that the statistical power increases when the design variabilitydecreases for a covariate in a logit model. Our theoretical findings are verified bysimulation results." @default.
• W2808141285 created "2018-06-21" @default.
• W2808141285 creator A5039012432 @default.
• W2808141285 date "2018-01-01" @default.
• W2808141285 modified "2023-09-23" @default.
• W2808141285 title "Statistical inference for adaptive designs in multi-center clinical trials" @default.
• W2808141285 cites W105627024 @default.
• W2808141285 cites W1216394864 @default.
• W2808141285 cites W1490768654 @default.
• W2808141285 cites W1528905581 @default.
• W2808141285 cites W1553818256 @default.
• W2808141285 cites W1955080364 @default.
• W2808141285 cites W1970502168 @default.
• W2808141285 cites W1979159029 @default.
• W2808141285 cites W1984684068 @default.
• W2808141285 cites W1987477151 @default.
• W2808141285 cites W1993531603 @default.
• W2808141285 cites W1993594029 @default.
• W2808141285 cites W2000366267 @default.
• W2808141285 cites W2002682396 @default.
• W2808141285 cites W2004818381 @default.
• W2808141285 cites W2009163891 @default.
• W2808141285 cites W2011667180 @default.
• W2808141285 cites W2016238739 @default.
• W2808141285 cites W2028042894 @default.
• W2808141285 cites W2030500137 @default.
• W2808141285 cites W2034124226 @default.
• W2808141285 cites W2034985579 @default.
• W2808141285 cites W2034998138 @default.
• W2808141285 cites W2037483654 @default.
• W2808141285 cites W2038830465 @default.
• W2808141285 cites W2039522160 @default.
• W2808141285 cites W2040312310 @default.
• W2808141285 cites W2042355708 @default.
• W2808141285 cites W2044439361 @default.
• W2808141285 cites W2049350168 @default.
• W2808141285 cites W2049877722 @default.
• W2808141285 cites W2049987923 @default.
• W2808141285 cites W2052205592 @default.
• W2808141285 cites W2058223996 @default.
• W2808141285 cites W2058796461 @default.
• W2808141285 cites W2061039755 @default.
• W2808141285 cites W2062161993 @default.
• W2808141285 cites W2063698478 @default.
• W2808141285 cites W2068787855 @default.
• W2808141285 cites W2068974024 @default.
• W2808141285 cites W2080801582 @default.
• W2808141285 cites W2081226821 @default.
• W2808141285 cites W2085733040 @default.
• W2808141285 cites W2088119380 @default.
• W2808141285 cites W2090893899 @default.
• W2808141285 cites W2093184664 @default.
• W2808141285 cites W2095002531 @default.
• W2808141285 cites W2098780272 @default.
• W2808141285 cites W2099953130 @default.
• W2808141285 cites W2102041666 @default.
• W2808141285 cites W2113379516 @default.
• W2808141285 cites W2122517286 @default.
• W2808141285 cites W2135338737 @default.
• W2808141285 cites W2143565945 @default.
• W2808141285 cites W2144849194 @default.
• W2808141285 cites W2170771993 @default.
• W2808141285 cites W2318082603 @default.
• W2808141285 cites W2618160794 @default.
• W2808141285 cites W2808085340 @default.
• W2808141285 cites W3102707029 @default.
• W2808141285 cites W3102828080 @default.
• W2808141285 cites W42241262 @default.
• W2808141285 cites W60929302 @default.
• W2808141285 cites W653925602 @default.
• W2808141285 cites W2041957500 @default.
• W2808141285 hasPublicationYear "2018" @default.
• W2808141285 type Work @default.
• W2808141285 sameAs 2808141285 @default.
• W2808141285 citedByCount "0" @default.
• W2808141285 crossrefType "dissertation" @default.
• W2808141285 hasAuthorship W2808141285A5039012432 @default.
• W2808141285 hasConcept C105795698 @default.
• W2808141285 hasConcept C119043178 @default.
• W2808141285 hasConcept C134261354 @default.
• W2808141285 hasConcept C140331021 @default.
• W2808141285 hasConcept C149782125 @default.
• W2808141285 hasConcept C153720581 @default.
• W2808141285 hasConcept C154945302 @default.
• W2808141285 hasConcept C185429906 @default.
• W2808141285 hasConcept C203274628 @default.
• W2808141285 hasConcept C2776214188 @default.
• W2808141285 hasConcept C2908647359 @default.
• W2808141285 hasConcept C33923547 @default.
• W2808141285 hasConcept C40696583 @default.
• W2808141285 hasConcept C41008148 @default.
• W2808141285 hasConcept C41587187 @default.
• W2808141285 hasConcept C71924100 @default.
• W2808141285 hasConcept C87007009 @default.
• W2808141285 hasConcept C99454951 @default.
• W2808141285 hasConceptScore W2808141285C105795698 @default.
• W2808141285 hasConceptScore W2808141285C119043178 @default.
• W2808141285 hasConceptScore W2808141285C134261354 @default.
• W2808141285 hasConceptScore W2808141285C140331021 @default.
• W2808141285 hasConceptScore W2808141285C149782125 @default.

• next