Matches in SemOpenAlex for { <https://semopenalex.org/work/W2808147756> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2808147756 endingPage "203" @default.
- W2808147756 startingPage "193" @default.
- W2808147756 abstract "Interleukin-1 receptor-like 1 (Il1rl1 or ST2), a member of the interleukin-1 receptor family, has pleiotropic roles including tissue homeostasis, inflammation, immune polarization, and disease resistance in mammals. A single orthologue was previously described in salmonid fish; however, a recently improved genome assembly of rainbow trout (Oncorhynchus mykiss) revealed three adjacent, tandem il1rl1 orthologues on chromosome Omy 03. Here, we report the genomic organization and evolution of the three il1rl1 genes (il1rl1α, il1rl1β, il1rl1γ), and use both RNA-seq and gene-specific qPCR methods to quantify expression patterns. Nucleotide sequence homology between the three genes is >95% and each predicted protein contains three IG/IG-like domains, a transmembrane region and a TIR domain. The amino acid sequence homology of the rainbow trout il1rl1 genes are highly related to two functional copies in Atlantic and Coho salmon (∼94%) but relatively low (22-26%) with avian and mammalian species. Transcript abundance measured by RNA-seq in 15 tissues of healthy adult rainbow trout indicate constitutive expression of each gene. In whole body lysates, il1rl1α was shown to have >20 fold mRNA expression compared to il1rl1β and il1rl1γ as measured by qPCR assays specific to il1rl1α or il1rl1γ, as well as a multi-gene qPCR assay (il1rl1α,β,γ). Unrooted phylogenetic trees grouped the rainbow trout il1rl1 genes apart from other interleukin-1 receptor family genes and genomic comparisons identify preserved synteny between mammals, birds and salmonids albeit a pseudogene is present in both Atlantic salmon and Coho salmon. Phylogenetic analyses suggest that the three genes arose by tandem duplication but are inconclusive whether these events occurred prior-to or after salmonid speciation. These findings further the understanding of interleukin receptor family evolution and their contribution to teleost immune function." @default.
- W2808147756 created "2018-06-21" @default.
- W2808147756 creator A5024955090 @default.
- W2808147756 creator A5051884995 @default.
- W2808147756 creator A5071779686 @default.
- W2808147756 date "2018-10-01" @default.
- W2808147756 modified "2023-09-26" @default.
- W2808147756 title "Differential expression and evolution of three tandem, interleukin-1 receptor-like 1 genes in rainbow trout (Oncorhynchus mykiss)" @default.
- W2808147756 cites W1966116114 @default.
- W2808147756 cites W1982325249 @default.
- W2808147756 cites W1998435868 @default.
- W2808147756 cites W2004806562 @default.
- W2808147756 cites W2010372009 @default.
- W2808147756 cites W2020101005 @default.
- W2808147756 cites W2023690137 @default.
- W2808147756 cites W2039211455 @default.
- W2808147756 cites W2055961987 @default.
- W2808147756 cites W2060729874 @default.
- W2808147756 cites W2087867951 @default.
- W2808147756 cites W2093816226 @default.
- W2808147756 cites W2095165154 @default.
- W2808147756 cites W2095308206 @default.
- W2808147756 cites W2097568300 @default.
- W2808147756 cites W2098926003 @default.
- W2808147756 cites W2108555555 @default.
- W2808147756 cites W2118777994 @default.
- W2808147756 cites W2128880918 @default.
- W2808147756 cites W2132926880 @default.
- W2808147756 cites W2134526812 @default.
- W2808147756 cites W2143092625 @default.
- W2808147756 cites W2153550523 @default.
- W2808147756 cites W2157710399 @default.
- W2808147756 cites W2162098634 @default.
- W2808147756 cites W2169456326 @default.
- W2808147756 cites W2257583092 @default.
- W2808147756 cites W2286751485 @default.
- W2808147756 cites W2311203695 @default.
- W2808147756 cites W2400245958 @default.
- W2808147756 cites W2530790166 @default.
- W2808147756 cites W2532676551 @default.
- W2808147756 doi "https://doi.org/10.1016/j.dci.2018.06.003" @default.
- W2808147756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29886053" @default.
- W2808147756 hasPublicationYear "2018" @default.
- W2808147756 type Work @default.
- W2808147756 sameAs 2808147756 @default.
- W2808147756 citedByCount "1" @default.
- W2808147756 countsByYear W28081477562022 @default.
- W2808147756 crossrefType "journal-article" @default.
- W2808147756 hasAuthorship W2808147756A5024955090 @default.
- W2808147756 hasAuthorship W2808147756A5051884995 @default.
- W2808147756 hasAuthorship W2808147756A5071779686 @default.
- W2808147756 hasBestOaLocation W28081477561 @default.
- W2808147756 hasConcept C104317684 @default.
- W2808147756 hasConcept C141231307 @default.
- W2808147756 hasConcept C150194340 @default.
- W2808147756 hasConcept C165525559 @default.
- W2808147756 hasConcept C2778961482 @default.
- W2808147756 hasConcept C2779363728 @default.
- W2808147756 hasConcept C2909208804 @default.
- W2808147756 hasConcept C2994167347 @default.
- W2808147756 hasConcept C34957205 @default.
- W2808147756 hasConcept C505870484 @default.
- W2808147756 hasConcept C54355233 @default.
- W2808147756 hasConcept C86803240 @default.
- W2808147756 hasConceptScore W2808147756C104317684 @default.
- W2808147756 hasConceptScore W2808147756C141231307 @default.
- W2808147756 hasConceptScore W2808147756C150194340 @default.
- W2808147756 hasConceptScore W2808147756C165525559 @default.
- W2808147756 hasConceptScore W2808147756C2778961482 @default.
- W2808147756 hasConceptScore W2808147756C2779363728 @default.
- W2808147756 hasConceptScore W2808147756C2909208804 @default.
- W2808147756 hasConceptScore W2808147756C2994167347 @default.
- W2808147756 hasConceptScore W2808147756C34957205 @default.
- W2808147756 hasConceptScore W2808147756C505870484 @default.
- W2808147756 hasConceptScore W2808147756C54355233 @default.
- W2808147756 hasConceptScore W2808147756C86803240 @default.
- W2808147756 hasFunder F4320306114 @default.
- W2808147756 hasFunder F4320332299 @default.
- W2808147756 hasFunder F4320332605 @default.
- W2808147756 hasLocation W28081477561 @default.
- W2808147756 hasLocation W28081477562 @default.
- W2808147756 hasOpenAccess W2808147756 @default.
- W2808147756 hasPrimaryLocation W28081477561 @default.
- W2808147756 hasRelatedWork W1964274011 @default.
- W2808147756 hasRelatedWork W1981393315 @default.
- W2808147756 hasRelatedWork W1999325162 @default.
- W2808147756 hasRelatedWork W2004096242 @default.
- W2808147756 hasRelatedWork W2029633625 @default.
- W2808147756 hasRelatedWork W2040571417 @default.
- W2808147756 hasRelatedWork W2053836572 @default.
- W2808147756 hasRelatedWork W2082080217 @default.
- W2808147756 hasRelatedWork W2139996627 @default.
- W2808147756 hasRelatedWork W4233150668 @default.
- W2808147756 hasVolume "87" @default.
- W2808147756 isParatext "false" @default.
- W2808147756 isRetracted "false" @default.
- W2808147756 magId "2808147756" @default.
- W2808147756 workType "article" @default.